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  • Springer  (349)
  • National Academy of Sciences  (37)
  • Seismological Society of America (SSA)
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  • 1
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    Two surfaces on the histone chaperone Rtt106 mediate histone binding, replication, and silencing [Genetics] (2012)
    National Academy of Sciences
    Details
    Publication Date: 2012-01-18
    Description: The histone chaperone Rtt106 binds histone H3 acetylated at lysine 56 (H3K56ac) and facilitates nucleosome assembly during several molecular processes. Both the structural basis of this modification-specific recognition and how this recognition informs Rtt106 function are presently unclear. Guided by our crystal structure of Rtt106, we identified two regions on its double-pleckstrin homology domain architecture that mediated histone binding. When histone binding was compromised, Rtt106 localized properly to chromatin but failed to deliver H3K56ac, leading to replication and silencing defects. By mutating analogous regions in the structurally homologous chromatin-reorganizer Pob3, we revealed a conserved histone-binding function for a basic patch found on both proteins. In contrast, a loop connecting two β-strands was required for histone binding by Rtt106 but was dispensable for Pob3 function. Unlike Rtt106, Pob3 histone binding was modification-independent, implicating the loop of Rtt106 in H3K56ac-specific recognition in vivo. Our studies described the structural origins of Rtt106 function, identified a conserved histone-binding surface, and defined a critical role for Rtt106:H3K56ac-binding specificity in silencing and replication-coupled nucleosome turnover.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Quinolones and Mycobacterium tuberculosis gyrase [Biochemistry] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-02-17
    Description: Mycobacterium tuberculosis is a significant source of global morbidity and mortality. Moxifloxacin and other fluoroquinolones are important therapeutic agents for the treatment of tuberculosis, particularly multidrug-resistant infections. To guide the development of new quinolone-based agents, it is critical to understand the basis of drug action against M. tuberculosis gyrase and...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Structure of tuberculosis quinolone-gyrase complex [Biochemistry] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-02-17
    Description: Mycobacterium tuberculosis (Mtb) infects one-third of the world’s population and in 2013 accounted for 1.5 million deaths. Fluoroquinolone antibacterials, which target DNA gyrase, are critical agents used to halt the progression from multidrug-resistant tuberculosis to extensively resistant disease; however, fluoroquinolone resistance is emerging and new ways to bypass resistance are...
    Keywords: Inaugural Articles
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Methylation represses p53 in teratocarcinoma [Cell Biology] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-08-31
    Description: TP53 (which encodes the p53 protein) is the most frequently mutated gene among all human cancers, whereas tumors that retain the wild-type TP53 gene often use alternative mechanisms to repress the p53 tumor-suppressive function. Testicular teratocarcinoma cells rarely contain mutations in TP53, yet the transcriptional activity of wild-type p53 is...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
    Electronic Resource
    Electronic Resource
    Zellmorphologische Veränderungen im Vaginalabstrich nach Strahleneinwirkung (1967)
    Springer
    Cellular and molecular life sciences 23 (1967), S. 879-883 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary (1) The vaginal smears show no definite criteria of susceptibility to radiation except for the disappearance of the atypical cells. (2) Nothing can be said about the diagnosis. Only the clinical status may enable the experienced gynaecologist to predict the prognosis. (3) The cytology of the vagina serves as an important guide to the progress of cases of carcinoma which had been radiated or operated. The diagnosis of recurrence of the local, highly differentiated carcinoma, following radiation may present difficulties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02146909
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  • 6
    Electronic Resource
    Electronic Resource
    The negative correlation between erythrocyte concentration and mean corpuscular haemoglobin or mean corpuscular volume in normal dogs (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 906-907 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In normal adult Beagle dogs red cell concentration decreased linearly with increasing mean red cell volume and mean red cell haemoglobin. The results are statistically significant (p〈0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01985707
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  • 7
    Electronic Resource
    Electronic Resource
    Identification of new enzyme activities of several strains of Thermus species (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 81-87 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract New thermostable enzyme activities of seven Thermus strains were compared using the API ZYM system. All the strains exhibited high levels of α- and β-glycosidases, esterase (C4) and esterase-lipase (C8) activities intracellularly. Only T. thermophilus HB8 (ATCC 27634) showed α-glucosidase and esterase activities in the supernatant. According to the intensity of β-galactosidase activity, Thermus strains were divided in three groups. Group 0, which showed a weak β-galactosidase activity, included Thermus spp. ATCC 31674 (T351) and 27978 (X-1) as well as T. thermophilus ATCC 27634 (HB8). Group I which consisted of T. aquaticus ATCC 25104 (YT-1), ATCC 25105 (Y-VII-51B) and Thermus sp. ATCC 27737 (T2), had a specific activity of approximately 40.0 U mg−1 and galactose as inducer. T. aquaticus ATCC 31558 (group 2) was particularly effective for β-galactosidase production (2840 U) with a specific activity of 98 U mg−1. For each strain, galactose (0.5%) was a better inducer of β-galactosidase production than lactose (1%). The detection of β-galactosidase activity was dependent on the derivative chromogenic substrates used (naphthyl or nitrophenol coupled to sugar). Oligosaccharides were synthesized from cellobiose, lactulose, maltose or lactose as substrates at high temperature in some strains of Thermus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00164484
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  • 8
    Electronic Resource
    Electronic Resource
    Identification of new enzyme activities of several strains of Thermus species (1995)
    Springer
    Applied microbiology and biotechnology 44 (1995), S. 81-87 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  New thermostable enzyme activities of seven Thermus strains were compared using the API ZYM system. All the strains exhibited high levels of α- and β-glycosidases, esterase (C4) and esterase-lipase (C8) activities intracellularly. Only T. thermophilus HB8 (ATCC 27634) showed α-glucosidase and esterase activities in the supernatant. According to the intensity of β-galactosidase activity, Thermus strains were divided in three groups. Group 0, which showed a weak β-galactosidase activity, included Thermus spp. ATCC 31674 (T351) and 27978 (X-1) as well as T. thermophilus ATCC 27634 (HB8). Group I which consisted of T. aquaticus ATCC 25104 (YT-1), ATCC 25105 (Y-VII-51B) and Thermus sp. ATCC 27737 (T2), had a specific activity of approximately 40.0 U mg-1 and galactose as inducer. T. aquaticus ATCC 31558 (group 2) was particularly effective for β-galactosidase production (2840 U) with a specific activity of 98 U mg-1. For each strain, galactose (0.5%) was a better inducer of β-galactosidase production than lactose (1%). The detection of β-galactosidase activity was dependent on the derivative chromogenic substrates used (naphthyl or nitrophenol coupled to sugar). Oligosaccharides were synthesized from cellobiose, lactulose, maltose or lactose as substrates at high temperature in some strains of Thermus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050523
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  • 9
    Electronic Resource
    Electronic Resource
    Driving traction on phase boundary interfaces in solids with boundary elements (1998)
    Springer
    Computational mechanics 22 (1998), S. 19-25 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A method of computing driving tractions for phase transformations is presented. The driving traction calculation requires evaluating the jump in the displacement gradient and the average stress acting across the interface. A bimaterial Green's function is used in a boundary element formulation for the calculation. The Green's function satisfies all interface boundary conditions for the bimaterial providing an efficient formulation for evaluating the necessary jump and average interface terms. We derive a boundary integral equation for calculating the driving traction and apply the developed numerical tool to driving traction calculations in copper-aluminum-nickel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004660050334
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  • 10
    Electronic Resource
    Electronic Resource
    Boundary integral equation formulation for Interface cracks in anisotropic materials (1997)
    Springer
    Computational mechanics 20 (1997), S. 261-266 
    Details
    ISSN: 1432-0924
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract We present a boundary integral formulation for anisotropic interface crack problems based on an exact Green's function. The fundamental displacement and traction solutions needed for the boundary integral equations are obtained from the Green's function. The traction-free boundary conditions on the crack faces are satisfied exactly with the Green's function so no discretization of the crack surfaces is necessary. The analytic forms of the interface crack displacement and stress fields are contained in the exact Green's function thereby offering advantage over modeling strategies for the crack. The Green's function contains both the inverse square root and oscillatory singularities associated with the elastic, anisotropic interface crack problem. The integral equations for a boundary element analysis are presented and an example problem given for interface cracking in a copper-nickel bimaterial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004660050246
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