ALBERT

Description: We demonstrate an innovative CIGS-based solar cells model with a graded doping concentration absorber profile, capable of achieving high efficiency values. In detail, we start with an in-depth discussion concerning the parametrical study of conventional CIGS solar cells structures. We have used the wxAMPS software in order to numerically simulate cell electrical behaviour. By means of simulations, we have studied the variation of relevant physical and chemical parameters—characteristic of such devices—with changing energy gap and doping density of the absorber layer. Our results show that, in uniform CIGS cell, the efficiency, the open circuit voltage, and short circuit current heavily depend on CIGS band gap. Our numerical analysis highlights that the band gap value of 1.40 eV is optimal, but both the presence of Molybdenum back contact and the high carrier recombination near the junction noticeably reduce the crucial electrical parameters. For the above-mentioned reasons, we have demonstrated that the efficiency obtained by conventional CIGS cells is lower if compared to the values reached by our proposed graded carrier concentration profile structures (up to 21%).

Description: This paper presents a study of transonic wings whose planform shape is curved. Using fluid structure interaction analyses, the dynamic instability conditions were investigated by including the effects of the transonic flow field around oscillating wings. To compare the dynamic aeroelastic characteristics of the curved wing configuration, numerical analyses were carried out on a conventional swept wing and on a curved planform wing. The results confirm that, for a curved planform wing, the dynamic instability condition occurs at higher flight speed if compared to a traditional swept wing with similar profiles, aspect ratio, angle of sweep at root, similar structural layout, and similar mass. A curved wing lifting system could thus improve the performances of future aircrafts.

Description: International Journal of Distributed Sensor Networks, Volume 15, Issue 3, March 2019. 〈br/〉

Description: Microgeneration is the small-scale generation of heat or electric power or both, by individuals or buildings to meet their own needs. Recently, microgeneration is being regarded as a means to decentralize the power production of renewable energies, reducing the impacts on the grid caused by unexpected energy demands. Given the increase in microgeneration facilities, determining the quantity of energy produced and the power quality assumes growing importance in low, medium, or high voltage facilities. This paper presents a power quality analysis of two different facilities with photovoltaic generation localized in a rural area of Portugal, describing the voltage and frequency behaviour, the harmonic contents, and the total harmonic distortion. Statistical data are presented regarding the number of voltage events and occurrence of dips and swells in both facilities as a percentage of rated voltage. We conclude that some PV systems can severely affect voltage quality, forcing the grid to work at and even above the maximum voltage standard limit.

Description: Wireless Personal or Body Area Networks (WPANs or WBANs) are the main mechanisms to develop healthcare systems for an ageing society. Such systems offer monitoring, security, and caring services by measuring physiological body parameters using wearable devices. Wireless sensor networks allow inexpensive, continuous, and real-time updates of the sensor data, to the data repositories via an Internet. A great deal of research is going on with a focus on technical, managerial, economic, and social health issues. The technical obstacles, which we encounter, in general, are better methodologies, architectures, and context data storage. Sensor communication, data processing and interpretation, data interchange format, data transferal, and context data storage are sensitive phases during the whole process of body parameter acquisition until the storage. ANT+ is a proprietary (but open access) low energy protocol, which supports device interoperability by mutually agreeing upon device profile standards. We have implemented a prototype, based upon ANT+ enabled sensors for a real-time scenario. This paper presents a system architecture, with its software organization, for real-time message interpretation, event-driven based real-time bidirectional communication, and schema flexible storage. A computer user uses it to acquire and to transmit the data using a Windows service to the context server.

Description: It has been proposed that the metal-drug complexes could be in fact the active agents displaying therapeutic effects of drugs. The characterization of the global formation equilibrium of complexes formed between metal ions and species with biological activity such as nonsteroidal anti-inflammatory drugs provides essential information to understand the mechanism of action of drugs. Since equilibrium constants determine the relative predominance of species, they provide crucial information to identify what complexes are more likely to be present in the system being responsible for the therapeutic effects of the drug. In this paper, the systems formed between copper and Indomethacin of different concentrations in ethanol or water were studied by UV-Vis spectrophotometry. The stoichiometry of the complexes Cu(II)–Indomethacin and their formation constants were investigated. Moreover, molecular structures of the Cu(II)–Indomethacin complexes were explored by means of the molecular modeling within the frame of the density functional theory.

Description: Genes, Vol. 8, Pages 247: Et tu, Brute? Not Even Intracellular Mutualistic Symbionts Escape Horizontal Gene Transfer Genes doi: 10.3390/genes8100247 Authors: Sergio López-Madrigal Rosario Gil Many insect species maintain mutualistic relationships with endosymbiotic bacteria. In contrast to their free-living relatives, horizontal gene transfer (HGT) has traditionally been considered rare in long-term endosymbionts. Nevertheless, meta-omics exploration of certain symbiotic models has unveiled an increasing number of bacteria-bacteria and bacteria-host genetic transfers. The abundance and function of transferred loci suggest that HGT might play a major role in the evolution of the corresponding consortia, enhancing their adaptive value or buffering detrimental effects derived from the reductive evolution of endosymbionts’ genomes. Here, we comprehensively review the HGT cases recorded to date in insect-bacteria mutualistic consortia, and discuss their impact on the evolutionary success of these associations.

Description: Genes, Vol. 8, Pages 253: Exonization of an Intronic LINE-1 Element Causing Becker Muscular Dystrophy as a Novel Mutational Mechanism in Dystrophin Gene Genes doi: 10.3390/genes8100253 Authors: Ana Gonçalves Jorge Oliveira Teresa Coelho Ricardo Taipa Manuel Melo-Pires Mário Sousa Rosário Santos A broad mutational spectrum in the dystrophin (DMD) gene, from large deletions/duplications to point mutations, causes Duchenne/Becker muscular dystrophy (D/BMD). Comprehensive genotyping is particularly relevant considering the mutation-centered therapies for dystrophinopathies. We report the genetic characterization of a patient with disease onset at age 13 years, elevated creatine kinase levels and reduced dystrophin labeling, where multiplex-ligation probe amplification (MLPA) and genomic sequencing failed to detect pathogenic variants. Bioinformatic, transcriptomic (real time PCR, RT-PCR), and genomic approaches (Southern blot, long-range PCR, and single molecule real-time sequencing) were used to characterize the mutation. An aberrant transcript was identified, containing a 103-nucleotide insertion between exons 51 and 52, with no similarity with the DMD gene. This corresponded to the partial exonization of a long interspersed nuclear element (LINE-1), disrupting the open reading frame. Further characterization identified a complete LINE-1 (~6 kb with typical hallmarks) deeply inserted in intron 51. Haplotyping and segregation analysis demonstrated that the mutation had a de novo origin. Besides underscoring the importance of mRNA studies in genetically unsolved cases, this is the first report of a disease-causing fully intronic LINE-1 element in DMD, adding to the diversity of mutational events that give rise to D/BMD.

Description: Genes, Vol. 9, Pages 195: TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor Genes doi: 10.3390/genes9040195 Authors: Danilo Swann Matassa Ilenia Agliarulo Rosario Avolio Matteo Landriscina Franca Esposito Metabolic reprogramming is an important issue in tumor biology. An unexpected inter- and intra-tumor metabolic heterogeneity has been strictly correlated to tumor outcome. Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1) is a molecular chaperone involved in the regulation of energetic metabolism in cancer cells. This protein is highly expressed in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers and is often associated with drug resistance. However, TRAP1 is also downregulated in specific tumors, such as ovarian, bladder and renal cancers, where its lower expression is correlated with the worst prognoses and chemoresistance. TRAP1 is the only mitochondrial member of the Heat Shock Protein 90 (HSP90) family that directly interacts with respiratory complexes, contributing to their stability and activity but it is still unclear if such interactions lead to reduced or increased respiratory capacity. The role of TRAP1 is to enhance or suppress oxidative phosphorylation; the effects of such regulation on tumor development and progression are controversial. These observations encourage the study of the mechanisms responsible for the dualist role of TRAP1 as an oncogene or oncosuppressor in specific tumor types. In this review, TRAP1 puzzling functions were recapitulated with a special focus on the correlation between metabolic reprogramming and tumor outcome. We wanted to investigate whether metabolism-targeting drugs can efficiently interfere with tumor progression and whether they might be combined with chemotherapeutics or molecular-targeted agents to counteract drug resistance and reduce therapeutic failure.

Description: In a nonlinear system, impasse points are singularities beyond which solutions are not continuable. In this article, we study two families of nonlinear electrical circuits, which can be represented by nonlinear Implicit Differential Equations. We set conditions that ensure the existence of impasse points in both families of circuits. In the literature, there exist general results to analyse the presence of such singularities in given differential equations of this type. However, the method proposed in this work allows detecting their existence in these electrical topologies in an extremely straightforward way, as illustrated by the examples of application.