ALBERT

Description: Indoor environments can be very complex. Due to the challenges in these environments in combination with the absence of mobile wayfinding aids, a great need exists for innovative research on indoor wayfinding. In this explorative study, a game was developed in Unity to investigate whether the concept of gamification could be used in studies on indoor wayfinding so as to provide useful information regarding the link between wayfinding performance, personal characteristics, and building layout. Results show a significant difference between gamers and non-gamers as the complexity of the player movement has an important impact on the navigation velocity in the game. However, further analysis reveals that the architectural layout also has an impact on the navigation velocity and that wrong turns in the game are influenced by the landmarks at the decision points: navigating at deeper decision points in convex spaces is slower and landmarks of the categories pictograms and infrastructural were more effective in this particular building. Therefore, this explorative study, which provides an approach for the use of gamification in indoor wayfinding research, has shown that serious games could be successfully used as a medium for data acquisition related to indoor wayfinding in a virtual environment.

Description: The outbreak of the COVID-19 virus in Wuhan, China, in January 2020 just before the Spring Festival and subsequent country-wide measures to contain the virus, effectively resulted in the lock-down of the country. Most industries and businesses were closed, traffic was largely reduced, and people were restrained to their homes. This resulted in the reduction of emissions of trace gases and aerosols, the concentrations of which were strongly reduced in many cities around the country. Satellite imagery from the TROPOspheric Monitoring Instrument (TROPOMI) showed an enormous reduction of tropospheric NO2 concentrations, but aerosol optical depth (AOD), as a measure of the amount of aerosols, was less affected, likely due to the different formation mechanisms and the influence of meteorological factors. In this study, satellite data and ground-based observations were used together to estimate the separate effects of the Spring Festival and the COVID-19 containment measures on atmospheric composition in the winter of 2020. To achieve this, data were analyzed for a period from 30 days before to 60 days after the Spring Festivals in 2017–2020. This extended period of time, including similar periods in previous years, were selected to account for both the decreasing concentrations in response to air pollution control measures, and meteorological effects on concentrations of trace gases and aerosols. Satellite data from TROPOMI provided the spatial distributions over mainland China of the tropospheric vertical column density (VCD) of NO2, and VCD of SO2 and CO. The MODerate resolution Imaging Spectroradiometer (MODIS) provided the aerosol optical depth (AOD). The comparison of the satellite data for different periods showed a large reduction of, e.g., NO2 tropospheric VCDs due to the Spring Festival of up to 80% in some regions, and an additional reduction due to the COVID-19 containment measures of up to 70% in highly populated areas with intensive anthropogenic activities. In other areas, both effects are very small. Ground-based in situ observations from 26 provincial capitals provided concentrations of NO2, SO2, CO, O3, PM2.5, and PM10. The analysis of these data was focused on the situation in Wuhan, based on daily averaged concentrations. The NO2 concentrations started to decrease a few days before the Spring Festival and increased after about two weeks, except in 2020 when they continued to be low. SO2 concentrations behaved in a similar way, whereas CO, PM2.5, and PM10 also decreased during the Spring Festival but did not trace NO2 concentrations as SO2 did. As could be expected from atmospheric chemistry considerations, O3 concentrations increased. The analysis of the effects of the Spring Festival and the COVID-19 containment measures was complicated due to meteorological influences. Uncertainties contributing to the estimates of the different effects on the trace gas concentrations are discussed. The situation in Wuhan is compared with that in 26 provincial capitals based on 30-day averages for four years, showing different effects across China.

Description: As nutrition is one of the modifiable risk factors for cognitive decline, we studied the relationship between dietary quality and clinical characteristics in cognitively normal individuals with subjective cognitive decline (SCD). We included 165 SCD subjects (age: 64 ± 8 years; 45% female) from the SCIENCe project, a prospective memory clinic based cohort study on SCD. The Dutch Healthy Diet Food Frequency Questionnaire (DHD-FFQ) was used to assess adherence to Dutch guidelines on vegetable, fruit, fibers, fish, saturated fat, trans fatty acids, salt and alcohol intake (item score 0–10, higher score indicating better adherence). We measured global cognition (Mini Mental State Examination), cognitive complaints (Cognitive Change Index self-report; CCI) and depressive symptoms (Center for Epidemiologic Studies Depression Scale; CES-D). Using principal component analysis, we identified dietary components and investigated their relation to clinical characteristics using linear regression models adjusted for age, sex and education. We identified three dietary patterns: (i) “low-Fat-low-Salt”, (ii) “high-Veggy”, and (iii) “low-Alcohol-low-Fish”. Individuals with lower adherence on “low-Fat-low-Salt” had more depressive symptoms (β −0.18 (−2.27–−0.16)). Higher adherence to “high-Veggy” was associated with higher MMSE scores (β 0.30 (0.21–0.64)). No associations were found with the low-Alcohol-low-Fish component. We showed that in SCD subjects, dietary quality was related to clinically relevant outcomes. These findings could be useful to identify individuals that might benefit most from nutritional prevention strategies to optimize brain health.

Description: Nutrition is one of the modifiable risk factors for cognitive decline and Alzheimer’s disease (AD) dementia, and is therefore highly relevant in the context of prevention. However, knowledge of dietary quality in clinical populations on the spectrum of AD dementia is lacking, therefore we studied the association between dietary quality and cognitive impairment in Alzheimer’s disease (AD) dementia, mild cognitive impairment (MCI) and controls. We included 357 participants from the NUDAD project (134 AD dementia, 90 MCI, 133 controls). We assessed adherence to dietary guidelines (components: vegetables, fruit, fibers, fish, saturated fat, trans-fat, salt, and alcohol), and cognitive performance (domains: memory, language, visuospatial functioning, attention, and executive functioning). In the total population, linear regression analyses showed a lower vegetable intake is associated with poorer global cognition, visuospatial functioning, attention and executive functioning. In AD dementia, lower total adherence to dietary guidelines and higher alcohol intake were associated with poorer memory, a lower vegetable intake with poorer global cognition and executive functioning, and a higher trans-fat intake with poorer executive functioning. In conclusion, a suboptimal diet is associated with more severely impaired cognition—this association is mostly attributable to a lower vegetable intake and is most pronounced in AD dementia.

Description: Vascular calcification is an independent predictor of cardiovascular disease, and therefore, inhibition or regression of this processes is of clinical importance. The standard care regarding prevention and treatment of cardiovascular disease at this moment mainly depends on drug therapy. In animal and preclinical studies, various forms of cardiovascular drug therapy seem to have a positive effect on vascular calcification. In particular, calcium channel blockers and inhibitors of the renin–angiotensin–aldosteron system slowed down arterial calcification in experimental animals. In humans, the results of trials with these drugs are far less pronounced and often contradictory. There is limited evidence that the development of new atherosclerotic lesions may be retarded in patients with coronary artery disease, but existing lesions can hardly be influenced. Although statin therapy has a proven role in the prevention and treatment of cardiovascular morbidity and mortality, it is associated with both regression and acceleration of the vascular calcification process. Recently, nutritional supplements have been recognized as a potential tool to reduce calcification. This is particularly true for vitamin K, which acts as an inhibitor of vascular calcification. In addition to vitamin K, other dietary supplements may also modulate vascular function. In this narrative review, we discuss the current state of knowledge regarding the pharmacological and nutritional possibilities to prevent the development and progression of vascular calcification.

Description: In China, atmospheric fine particulate matter (PM2.5) pollution is a challenging environmental problem. Systematic PM2.5 measurements have started only in 2013, resulting in a lack of historical data which is a key obstacle for the analysis of long-term PM2.5 trends and forecasting the evolution over this hot region. Satellite data can provide a new approach to derive historical PM2.5 information provided that the column-integrated aerosol properties can adequately be converted to PM2.5. In this study, a recently developed formulation for the calculation of surface PM2.5 concentrations using satellite data is introduced and applied to reconstruct a PM2.5 time series over China from 2000 to 2015. The formulated model is also used to explore the PM2.5 driving factors related to anthropogenic or meteorological parameters in this historical period. The results show that the annually averaged PM2.5 over China’s polluted regions increased rapidly between 2004 and 2007 (with an average rate of 3.07 μg m−3 yr−1) to reach values of up to 61.1 μg m−3 in 2007, and decreased from 2011 to 2015 with an average rate of −2.61 μg m−3 yr−1, to reach a value of 46.9 μg m−3 in 2015. The analysis shows that the increase in PM2.5 before 2008 was mainly associated with increasing anthropogenic factors, further augmented by the effect of meteorological influences. However, the decrease in PM2.5 after 2011 is mainly attributed to the effect of pollution control measures on anthropogenic factors, whereas the effects of meteorological factors have continued to increase since 2000. The results also suggest that further reduction in anthropogenic emissions is needed to accelerate the decrease in PM2.5 concentrations to reach the target of 35 μg m−3 over major polluted areas in China before 2025.

Description: Land use land cover (LULC) of city regions is strongly affected by urbanization and affects the thermal environment of urban centers by influencing the surface temperature of core city areas and their surroundings. These issues are addressed in the current study, which focuses on two provincial capitals in Pakistan, i.e., Lahore and Peshawar. Using Landsat data, LULC is determined with the aim to (a) examine the spatio-temporal changes in LULC over a period of 20 years from 1998 to 2018 using a CA-Markov model, (b) predict the future scenarios of LULC changes for the years 2023 and 2028, and (c) study the evolution of different LULC categories and investigate its impacts on land surface temperature (LST). The results for Peshawar city indicate the significant expansion in vegetation and built-up area replacing barren land. The vegetation cover and urban area of Peshawar have increased by 25.6%, and 16.3% respectively. In contrast, Lahore city urban land has expanded by 11.2% while vegetation cover decreased by (22.6%). These transitions between LULC classes also affect the LST in the study areas. Transformation of vegetation cover and water surface into built-up areas or barren land results in the increase in the LST. In contrast, the transformation of urban areas and barren land into vegetation cover or water results in the decrease in LST. The different LULC evolutions in Lahore and Peshawar clearly indicate their effects on the thermal environment, with an increasing LST trend in Lahore and a decrease in Peshawar. This study provides a baseline reference to urban planners and policymakers for informed decisions.

Description: The Corona Virus Disease 2019 (COVID-19) appeared in Wuhan, China, at the end of 2019, spreading from there across China and within weeks across the whole world. In order to control the rapid spread of the virus, the Chinese government implemented a national lockdown policy. It restricted human mobility and non-essential economic activities, which, as a side effect, resulted in the reduction of the emission of pollutants and thus the improvement of the air quality in many cities in China. In this paper, we report on a study on the changes in air quality in the Guanzhong Basin during the COVID-19 lockdown period. We compared the concentrations of PM2.5, PM10, SO2, NO2, CO and O3 obtained from ground-based monitoring stations before and after the COVID-19 outbreak. The analysis confirmed that the air quality in the Guanzhong Basin was significantly improved after the COVID-19 outbreak. During the emergency response period with the strictest restrictions (Level-1), the concentrations of PM2.5, PM10, SO2, NO2 and CO were lower by 37%, 30%, 29%, 52% and 33%, respectively, compared with those before the COVID-19 outbreak. In contrast, O3 concentrations increased substantially. The changes in the pollutant concentrations varied between cities during the period of the COVID-19 pandemic. The highest O3 concentration changes were observed in Xi’an, Weinan and Xianyang city; the SO2 concentration decreased substantially in Tongchuan city; the air quality had improved the most in Baoji City. Next, to complement the sparsely distributed air quality ground-based monitoring stations, the geographic and temporally weighted regression (GTWR) model, combined with satellite observations of the aerosol optical depth (AOD) and meteorological factors was used to estimate the spatial and temporal distributions of PM2.5 and PM10 concentrations with a resolution of 6 km × 6 km before and after the COVID-19 outbreak. The model was validated by a comparison with ground-based observations from the air quality monitoring network in five cities in the Guanzhong Basin with excellent statistical metrics. For PM2.5 and PM10 the correlation coefficients R2 were 0.86 and 0.80, the root mean squared errors (RMSE) were 11.03 µg/m3 and 14.87 µg/m3 and the biases were 0.19 µg/m3 and −0.27 µg/m3, which led to the conclusion that the GTWR model could be used to estimate the PM concentrations in locations where monitoring data were not available. Overall, the PM concentrations in the Guanzhong Basin decreased substantially during the lockdown period, with a strong initial decrease and a slower one thereafter, although the spatial distributions remained similar.

Description: As malnutrition is common in patients with Alzheimer’s disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 participants, of which 198 patients had AD, 135 patients had MCI and 219 controls. We assessed nutritional status (mini nutritional assessment (MNA)) and body composition (body mass index (BMI), fat-free mass (FFM) and waist circumference). Linear regression analyses (adjusted for age, gender and education where appropriate) were applied to test associations of AD biomarkers and cognitive performance on five domains with nutritional parameters (dependent). Patients with MCI and AD had a lower BMI and MNA score than controls. Worse performance in all cognitive domains was associated with lower MNA score, but not with body composition. AD biomarkers were associated with MNA score, BMI and waist circumference, and associations with MNA score remained after adjustment for cognitive performance. Both AD biomarkers and cognitive performance were associated with nutritional status, associations with AD biomarkers remained after adjustment for cognition. Our data suggest that malnutrition is not only related to impaired cognition but also to AD pathology.