ISSN:
0018-019X
Schlagwort(e):
Chemistry
;
Organic Chemistry
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Synthesis of Deuteriated Derivatives of Diastereomeric Cyclopentapeptides for Use in Conformational Analysis.The syntheses and properties of eight cyclic pentapeptides containing glycine with two deuterium atoms at C(α) (Gly*) are described: cyclo-[-Gly-L-Cys(DPM)-Gly-Gly*-L-Pro-], cyclo-[-Gly*-L-Cys(DPM)-Gly-Gly*-L-Pro-], cyclo-[-Gly-L-Cys-(DPM)-Gly-Gly*-D-Pro-], cyclo-[-Gly*-L-Cys(DPM)-Gly-Gly*-D-Pro-], cyclo-[-Gly-L-Ala-Gly-Gly*-L-Pro-], cyclo-[-Gly*-L-Ala-Gly-Gly*-L-Pro-], cyclo-[-Gly-L-Ala-Gly-Gly*-D-Pro-], and cyclo-[-Gly*-L-Ala-Gly-Gly*-D-Pro-] (DPM = diphenylmethyl). These particular compounds were chosen in order to assign by NMR. unambiguously certain conformational features, like hydrogen-bonding and shielding, to individual peptide bonds.
Zusätzliches Material:
1 Tab.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1002/hlca.19760590632
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