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  • MDPI Publishing  (1)
  • Molecular Diversity Preservation International  (1)
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  • 1
    Publication Date: 2017-09-29
    Description: Energies, Vol. 10, Pages 1510: Development and Experimental Validation of a TRNSYS Dynamic Tool for Design and Energy Optimization of Ground Source Heat Pump Systems Energies doi: 10.3390/en10101510 Authors: Félix Ruiz-Calvo Carla Montagud Antonio Cazorla-Marín José M. Corberán Ground source heat pump (GSHP) systems stand for an efficient technology for renewable heating and cooling in buildings. To optimize not only the design but also the operation of the system, a complete dynamic model becomes a highly useful tool, since it allows testing any design modifications and different optimization strategies without actually implementing them at the experimental facility. Usually, this type of systems presents strong dynamic operating conditions. Therefore, the model should be able to predict not only the steady-state behavior of the system but also the short-term response. This paper presents a complete GSHP system model based on an experimental facility, located at Universitat Politècnica de València. The installation was constructed in the framework of a European collaborative project with title GeoCool. The model, developed in TRNSYS, has been validated against experimental data, and it accurately predicts both the short- and long-term behavior of the system.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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  • 2
    Publication Date: 2020-03-23
    Description: Background: Epigenetic changes in obstructive sleep apnea (OSA) have been proposed as a mechanism for end-organ vulnerability. In children with OSA, Forkhead Box P3 (FOXP3) DNA methylation were associated with inflammatory biomarkers; however, the methylation pattern and its effect in the expression of this gene have not been tested in adults with OSA. Methods: Plasma samples from subjects without comorbid conditions other than OSA were analyzed (the Epigenetics Status and Subclinical Atherosclerosis in Obstructive Sleep Apnea (EPIOSA) Study: NCT02131610). In 16 patients with severe OSA (Apnea-Hypopnea Index—AHI- 〉 30 events/h) and seven matched controls (AHI 〈 5), methylation of FOXP3 gen was evaluated by PCR of the promoter and by pyrosequencing of the intron 1 Treg-specific demethylated region (TSDR). In another 74 patients with OSA (AHI 〉 10) and 31 controls, we quantified FOXP3 protein expression by ELISA and gene expression by quantitative real-time PCR. C-reactive protein (CRP) and plasma Treg cells were also evaluated. Results: Neither the levels of the promoter nor the TSDR demethylated region were different between controls and patients with OSA, whether they were grouped by normal or high CRP. FOXP3 protein and mRNA expression did not differ between groups. Conclusions: FOXP3 methylation or its expression is not altered in adults with OSA, whatever their inflammatory status.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
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