ALBERT

Description: We present a multi-proxy approach to reconstructing Holocene climate conditions in northeastern Spain based on an excellent correlation among the lamina thickness, colour parameters and isotope (δ 18 O and δ 13 C) variations recorded in a speleothem. An age model constructed from five U/Th dates and annual lamina counting suggests that the uppermost 14.7 cm of the MO-7 stalagmite grew between 7.2 and 2.5 kyr before present but experienced a growth hiatus from 4.9 to 4.3 kyr. Three spectral analysis methods were applied to 11 time series. The results reveal common solar periodicities on decennial (Gleissberg cycle) and centennial (De Vries-Suess cycle) scales. The onset of Holocene carbonate precipitation in the MO-7 stalagmite appears to be associated with a cold, wet period, whereas the hiatus and the end of growth are related to warm, dry periods. This environmental trend fits well within the regional Holocene climate. This article is protected by copyright. All rights reserved.

Description: We explored the submarine portions of the Enriquillo-Plantain-Garden Fault zone (EPGFZ) and the Septentrional-Oriente Fault zone (SOFZ) along the Northern Caribbean plate boundary using high-resolution multi-beam echo-sounding and shallow seismic reflection. The bathymetric data shed light on poorly documented or previously unknown submarine fault zones running over 200 km between Haiti and Jamaica (EPGFZ) and 300 km between the Dominican Republic and Cuba (SOFZ). The primary plate-boundary structures are a series of strike-slip fault segments associated with pressure ridges, restraining bends, step-overs and dogleg offsets indicating very active tectonics. Several distinct segments 50 to 100 km long cut across pre-existing structures inherited from former tectonic regimes or bypass recent morphologies formed under the current strike-slip regime. Along the most recent trace of the SOFZ, we measured a strike-slip offset of 16.5 km, which indicates steady activity for the past ~1.8 Ma if its current GPS-derived motion of 9.8 ± 2 mm/yr has remained stable during the entire Quaternary. This article is protected by copyright. All rights reserved.

Description: Here; we have described and tested a microarray based-method for the screening of dengue virus (DENV) serotypes. This DNA microarray assay is specific and sensitive and can detect dual infections with two dengue virus serotypes and single-serotype infections. Other methodologies may underestimate samples containing more than one serotype. This technology can be used to discriminate between the four DENV serotypes. Single-stranded DNA targets were covalently attached to glass slides and hybridised with specific labelled probes. DENV isolates and dengue samples were used to evaluate microarray performance. Our results demonstrate that the probes hybridized specifically to DENV serotypes; with no detection of unspecific signals. This finding provides evidence that specific probes can effectively identify single and double infections in DENV samples.

Description: Sensors, Vol. 18, Pages 1807: Considerations about the Determination of the Depolarization Calibration Profile of a Two-Telescope Lidar and Its Implications for Volume Depolarization Ratio Retrieval Sensors doi: 10.3390/s18061807 Authors: Adolfo Comerón Alejandro Rodríguez-Gómez Michaël Sicard Rubén Barragán Constantino Muñoz-Porcar Francesc Rocadenbosch María José Granados-Muñoz We propose a new method for calculating the volume depolarization ratio of light backscattered by the atmosphere and a lidar system that employs an auxiliary telescope to detect the depolarized component. It takes into account the possible error in the positioning of the polarizer used in the auxiliary telescope. The theory of operation is presented and then applied to a few cases for which the actual position of the polarizer is estimated, and the improvement of the volume depolarization ratio in the molecular region is quantified. In comparison to the method used before, i.e., without correction, the agreement between the volume depolarization ratio with correction and the theoretical value in the molecular region is improved by a factor of 2–2.5.

Description: Energies, Vol. 11, Pages 1064: Comparison of Different Technologies for Integrated Solar Combined Cycles: Analysis of Concentrating Technology and Solar Integration Energies doi: 10.3390/en11051064 Authors: Antonio Rovira Consuelo Sánchez Manuel Valdés Ruben Abbas Rubén Barbero María José Montes Marta Muñoz Javier Muñoz-Antón Guillermo Ortega Fernando Varela This paper compares the annual performance of Integrated Solar Combined Cycles (ISCCs) using different solar concentration technologies: parabolic trough collectors (PTC), linear Fresnel reflectors (LFR) and central tower receiver (CT). Each solar technology (i.e. PTC, LFR and CT) is proposed to integrate solar energy into the combined cycle in two different ways. The first one is based on the use of solar energy to evaporate water of the steam cycle by means of direct steam generation (DSG), increasing the steam production of the high pressure level of the steam generator. The other one is based on the use of solar energy to preheat the pressurized air at the exit of the gas turbine compressor before it is introduced in the combustion chamber, reducing the fuel consumption. Results show that ISCC with DSG increases the yearly production while solar air heating reduces it due to the incremental pressure drop. However, air heating allows significantly higher solar-to-electricity efficiencies and lower heat rates. Regarding the solar technologies, PTC provides the best thermal results.

Description: IJERPH, Vol. 15, Pages 1418: Urinary Inorganic Arsenic Concentration and Gestational Diabetes Mellitus in Pregnant Women from Arica, Chile International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15071418 Authors: María Pía Muñoz Macarena Valdés María Teresa Muñoz-Quezada Boris Lucero Paola Rubilar Paulina Pino Verónica Iglesias Introduction: The association of total arsenic exposure with impaired glucose tolerance and gestational diabetes has been shown; however, evidence regarding urinary inorganic arsenic in pregnant women is still limited. Our aim was to evaluate the association between urinary inorganic arsenic concentration and gestational diabetes among pregnant women living in Arica, Chile. Methods: Cross-sectional study of pregnant women receiving care at primary health centers in urban Arica. The exposure was urinary inorganic arsenic concentration, while gestational diabetes was the outcome. The association was evaluated using multiple logistic regression models adjusted by age, education level, ethnicity, and pre-pregnancy body mass index. Results: 244 pregnant women were surveyed. The median urinary inorganic arsenic was 14.95 μg/L, and the prevalence of gestational diabetes was 8.6%. After adjusting, we did not find a significant association between gestational diabetes and inorganic arsenic exposure tertiles (Odds ratio (OR) 2.98, 95% CI = 0.87–10.18), (OR 1.07, 95% CI = 0.26–4.33). Conclusion: This study did not provide evidence on the relationship between urinary inorganic arsenic concentration and gestational diabetes. Further research is needed to elucidate the factors underlying this association.

Description: Sensors, Vol. 18, Pages 1399: Force Trends and Pulsatility for Catheter Contact Identification in Intracardiac Electrograms during Arrhythmia Ablation Sensors doi: 10.3390/s18051399 Authors: David Rivas-Lalaleo Sergio Muñoz-Romero Mónica Huerta Mayra Erazo-Rodas Juan José Sánchez-Muñoz José Luis Rojo-Álvarez Arcadi García-Alberola The intracardiac electrical activation maps are commonly used as a guide in the ablation of cardiac arrhythmias. The use of catheters with force sensors has been proposed in order to know if the electrode is in contact with the tissue during the registration of intracardiac electrograms (EGM). Although threshold criteria on force signals are often used to determine the catheter contact, this may be a limited criterion due to the complexity of the heart dynamics and cardiac vorticity. The present paper is devoted to determining the criteria and force signal profiles that guarantee the contact of the electrode with the tissue. In this study, we analyzed 1391 force signals and their associated EGM recorded during 2 and 8 s, respectively, in 17 patients (82 ± 60 points per patient). We aimed to establish a contact pattern by first visually examining and classifying the signals, according to their likely-contact joint profile and following the suggestions from experts in the doubtful cases. First, we used Principal Component Analysis to scrutinize the force signal dynamics by analyzing the main eigen-directions, first globally and then grouped according to the certainty of their tissue-catheter contact. Second, we used two different linear classifiers (Fisher discriminant and support vector machines) to identify the most relevant components of the previous signal models. We obtained three main types of eigenvectors, namely, pulsatile relevant, non-pulsatile relevant, and irrelevant components. The classifiers reached a moderate to sufficient discrimination capacity (areas under the curve between 0.84 and 0.95 depending on the contact certainty and on the classifier), which allowed us to analyze the relevant properties in the force signals. We conclude that the catheter-tissue contact profiles in force recordings are complex and do not depend only on the signal intensity being above a threshold at a single time instant, but also on time pulsatility and trends. These findings pave the way towards a subsystem which can be included in current intracardiac navigation systems assisted by force contact sensors, and it can provide the clinician with an estimate of the reliability on the tissue-catheter contact in the point-by-point EGM acquisition procedure.

Description: Sensors, Vol. 17, Pages 2957: An Architecture Providing Depolarization Ratio Capability for a Multi-Wavelength Raman Lidar: Implementation and First Measurements Sensors doi: 10.3390/s17122957 Authors: Alejandro Rodríguez-Gómez Michaël Sicard María-José Granados-Muñoz Enis Ben Chahed Constantino Muñoz-Porcar Rubén Barragán Adolfo Comerón Francesc Rocadenbosch Eric Vidal A new architecture for the measurement of depolarization produced by atmospheric aerosols with a Raman lidar is presented. The system uses two different telescopes: one for depolarization measurements and another for total-power measurements. The system architecture and principle of operation are described. The first experimental results are also presented, corresponding to a collection of atmospheric conditions over the city of Barcelona.

Description: Sensors, Vol. 18, Pages 2475: Reduction of the Measurement Time by the Prediction of the Steady-State Response for Quartz Crystal Microbalance Gas Sensors Sensors doi: 10.3390/s18082475 Authors: Diana L. Osorio-Arrieta José L. Muñoz-Mata Georgina Beltrán-Pérez Juan Castillo-Mixcóatl Claudia O. Mendoza-Barrera Víctor Altuzar-Aguilar Severino Muñoz-Aguirre This paper presents a new approach to reduce the measurement time by the prediction of the steady-state using the transient response to ethanol for quartz crystal microbalance gas sensors coated with ethyl cellulose. The experimentally measured response curves were successively fitted using a mathematical model based on the sum of two exponentials with different time constants. The parameters of the model were determined, and the time constants and the magnitude of the steady-state response were analyzed. Even though the time constants did not stabilize well, the parameter corresponding to the magnitude of the steady-state response quickly converged and stabilized after 37 s. Moreover, this calculated parameter was highly correlated with the measured values of the steady-state response, which was measured at five times the longest time constant (83 s) of the model. Therefore, the steady-state response could be predicted with a 55% reduction in the measurement (detection) time.

Description: ABSTRACT Substance P (SP) is a neuropeptide belonging to the thachykinin peptide family. SP, after binding to its receptor, the neurokinin 1 receptor (NK1R), controls several transcription factors such as NF-κB, hypoxia inducible factor (HIF-1α), c-myc, c-fos, c-jun and AP-1. SP and NK1R have a widespread distribution in both the central and peripheral nervous systems. They are also present in cells not belonging to the nervous system (immune cells, placenta, etc.). SP is located in all body fluids, i.e., blood, cerebrospinal fluid, etc., making it ubiquitous throughout the human body. SP and NK1R genes are expressed in the stem cell line TF-1 and in primary stem cells derived from human placental cord blood. However, to our knowledge, the presence of SP and the NK1R receptor in adipose stem cells (ADSC) is unknown. We demonstrated by immunofluorescence the localization of SP and NK1R in human and rat ADSC. SP and NK1R are located in both the cytoplasm and the nucleus of these cells. The NK1R is higher in the nucleus than in the cytoplasm of ADSCs. By Western blot we demonstrated the presence of different isoforms of NK1R that have different subcellular locations in the ADSC. SP induces proliferation and mitogenesis through NK1R in ADSCs. These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the ADSCs. This article is protected by copyright. All rights reserved