ISSN:
1600-5759
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
Benzyl N-[8-(4,4-dimethyl-5-oxo-4,5-dihydrooxazol-2-yl)-2,5,5,8-tetramethyl-3,6-dioxo-4,7-diazanon-2-yl]carbamate, C24H34N4O6, an oxazol-5(4H)-one from N-α-benzyloxycarbonyl-(Aib)4-OH (Aib = α-aminoisobutyryl) represents the longest peptide oxazolone so far characterized by X-ray diffraction. The overall geometry of the oxazolone ring compares well with literature data. The Aib(1) and Aib(2) residues are folded into a type III β-bend, while the conformation adopted by Aib(3), preceding the oxazolone moiety, is semi-extended. The disposition of the oxazolone ring relative to the preceding residue is stabilized by C—H...N and C—H...O intramolecular interactions.Alternative name: 4,4-dimethyl-2-[1-(phenylmethoxycarbonyl-2-methylalanyl-2-methylalanylamino)-1-methylethyl]oxazol-5(4H)-one.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S0108270100003413
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