ISSN:
1600-5759
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
The title compound, sodium 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxoisobenzofuran-5-yl)-4-methylhex-4-enoate, Na+·C17H19O6−, is the sodium salt of the natural immunosuppressant compound mycophenolic acid. It consists of a phthalide moiety carrying four different substituents on the aromatic ring. The anion has no intramolecular hydrogen bonds, but a very strong intermolecular hydrogen bond links the phenolic hydroxy group to the carboxyl group of a neighbouring anion found in the same layer. Within a distance of 2.71 Å, the Na+ ion is surrounded by five O atoms from four different anions, forming a distorted square pyramid. This Na—O network forms an infinite two-dimensional system running parallel to the bc plane.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S0108270100000524
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