ISSN:
1399-0047
Source:
Crystallography Journals Online : IUCR Backfile Archive 1948-2001
Topics:
Chemistry and Pharmacology
,
Geosciences
,
Physics
Notes:
The crystal structure of the decamer d(GGCAATTGCG) has been determined at 2.4 Å resolution. The central eight bases of each DNA single-strand base pair with a self-complementary strand to form an octamer B-DNA duplex. These duplexes lie end-to-end within the unit cell. The terminal 5′-G and G-3′ bases of each decamer strand are unpaired, and interact with the neighbouring duplexes via interactions within both the major and minor groove. This results in base triplets of the type G—(G·C) and G*(G·C), with the third guanine base binding to a Watson–Crick G·C base pair from the major groove and the minor groove, respectively. The triplet interaction of the type G—(G·C) involves Hoogsteen hydrogen-bonding interactions between the two guanine bases. The minor- and major-groove base triplet interactions which exist within this structure act to stabilize the d(GCAATTGC)2 B-DNA octamer duplex.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1107/S090744499701559X
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