Publication Date:
2017-07-07
Description:
Composite hemostatic sponge was prepared by vacuum freeze-drying using carboxymethyl chitosan and sodium alginate as the main materials and CaCl 2 as a crosslinking agent. On the basis of single factor experiments, an orthogonal experiment was carried out to optimize the preparation process of hemostatic sponge. The appearance, water absorption, porosity ratio, and in vitro hemostasis of the sponge were evaluated. The optimum conditions to prepare hemostatic sponge were obtained as follows: mass ratio of sodium alginate to carboxymethyl chitosan 4: 1, mass fraction of CaCl 2 2%, and crosslinking temperature 30°C. The hemostatic sponge prepared under such conditions was off-white and porous. Its water absorption and porosity ratio were 3050% and 67.23%, respectively. Meanwhile, the hemostatic sponges had significant in vitro procoagulant activity. Therefore, the hemostatic sponge is expected to be developed as a novel medical material.
Print ISSN:
1757-8981
Electronic ISSN:
1757-899X
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Permalink
