Publication Date:
2011-07-09
Description:
Hydrogels able to form a bone-like hydroxyapatite (HAp) layer in the body environment are attractive materials as scaffolds for tissue engineering because they show osteoconductivity, i.e. bone-bonding property. In the present study, we synthesized hydrogels from sodium carboxymethylcellulose (sCMC), a water soluble polymer, through modification with a cross-linking agent, either ethylenediamine (EDA) or 3-aminopropyltriethoxysilane (APTES), followed by treatment with an aqueous solution containing calcium chloride aqueous solution. Formation of the bone-like HAp on the hydrogels was evaluated after immersion in a simulated body fluid (SBF). Hydrogels modified with the cross-linking agents EDA or APTES, and treated with 0.1 mol/dm 3 of calcium chloride aqueous solution, formed a bone-like HAp layer on their surfaces after immersion in SBF for 3 days. Modification of organic polymers rich in carboxyl groups with APTES and CaCl 2 offers a new method to produce ...
Print ISSN:
1757-8981
Electronic ISSN:
1757-899X
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
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