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  • 1
    Publication Date: 2020-05-20
    Description: Farfarae flos (FF) is widely used for cough over thousands of years in China, but little is known about their pharmacokinetics properties. This study was aimed to establish a rapid and accurate ultraperformance liquid chromatography with triple-quadrupole tandem mass spectrometry method for compare pharmacokinetics studies of eight active compounds after oral administration between raw and honey-processed farfarae flos extracts. Optimum separation was performed on a Thermo Hypersil GOLD C18 column (100 mm × 2.1 mm, 1.9 µm particles size) with a gradient elution of acetonitrile as mobile phase A and 0.3% formic acid aqueous solution as mobile phase B. The flow rate was set as 0.3 mL/min and separated for 34.0 minutes. Electrospray ionization in the negative ion mode and selected reaction monitoring were used to identify and separate active components. The results met the acceptance criteria and showed that this method exhibited good linear, precision, accuracy, and stability. The extraction recoveries ranged from 81.54% to 104.48%, and the matrix effects ranged from 81.94% to 103.02%. These results show that the validated method could be successfully applied to evaluate the pharmacokinetic study in rats after oral administration of raw farfarae flos (R-FF) and honey-processed farfarae flos (H-FF).
    Print ISSN: 2090-8865
    Electronic ISSN: 2090-8873
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 2
    Publication Date: 2020-09-08
    Description: Using the hydrodynamic software Fluidyn, a numerical model comprising a top-sealed vertical inspection well and a horizontal well with openings at both ends was built based on symmetry, to study the explosion propagation of flammable gases in typical municipal sewage pipelines. The vertical well had a diameter of 0.7 m and different depths (2 m, 4 m, and 6 m), and the horizontal well had a diameter of 0.8 m and a length of 20 m at both sides. The effects of different ignition positions, well depths, and gas compositions and concentrations on the explosion characteristics and rules governing the propagation of flammable gases in a municipal sewage pipeline were investigated. The findings suggest that different ignition positions (at the top, middle, and bottom of the inspection well) did not lead to a significant difference between peak explosion pressure and temperatures but had a substantial influence on the propagation velocity of the explosion flame near the corner of the junction between the vertical inspection well and the horizontal well. Different inspection well depths had no significant impact on the peak explosion pressure or temperature but had a substantial effect on the propagation velocity of the explosion flame at the bottom of the well. Compared with a methane (CH4) explosion at a concentration of 6%, the peak explosion pressure, peak explosion temperature, and flame propagation velocity of a CH4 and oil-gas mixture at a concentration ratio of 6% : 1% were found to be significantly higher. With increasing oil-gas concentrations (2%, 4%, and 6%), the peak pressure, temperature, and flame propagation velocity continued to decrease. The findings of this study can help prevent explosion accidents in municipal sewage pipelines and provide a reference to support the establishment of related standards.
    Print ISSN: 1687-8086
    Electronic ISSN: 1687-8094
    Topics: Architecture, Civil Engineering, Surveying
    Published by Hindawi
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  • 3
    Publication Date: 2016-01-01
    Description: Vehicle sideslip angle is essential for active safety control systems. This paper presents a new hybrid Kalman filter to estimate vehicle sideslip angle based on the 3-DoF nonlinear vehicle dynamic model combined with Magic Formula tire model. The hybrid Kalman filter is realized by combining square-root cubature Kalman filter (SCKF), which has quick convergence and numerical stability, with square-root cubature based receding horizon Kalman FIR filter (SCRHKF), which has robustness against model uncertainty and temporary noise. Moreover, SCKF and SCRHKF work in parallel, and the estimation outputs of two filters are merged by interacting multiple model (IMM) approach. Experimental results show the accuracy and robustness of the hybrid Kalman filter.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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