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  • Springer  (159)
  • National Academy of Sciences  (47)
  • Copernicus  (22)
  • American Association for the Advancement of Science (AAAS)  (6)
  • 1
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    Production of no-carrier-added 64Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer (2009)
    Springer
    Details
    Publication Date: 2009-03-18
    Print ISSN: 0236-5731
    Electronic ISSN: 1588-2780
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Published by Springer
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Effect of onion (Allium cepa) root exudates on the hyphal growth of Gigaspora margarita (1995)
    Springer
    Mycorrhiza 6 (1995), S. 57-59 
    Details
    ISSN: 1432-1890
    Keywords: Key words Arbuscular mycorrhizae ; Gigaspora margarita ; Allium cepa ; Phosphorus ; Root exudate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The effect of root exudates from onions differing in P status on spore germination and hyphal growth of arbuscular mycorrhizal fungi was investigated. Onion (Allium cepa) was grown in solution culture at different phosphorus concentrations (0, 0.1, 1.0, 8.0 and 24.0 mg P l–1) and root exudates were collected. When spores of the arbuscular mycorrhizal fungus, Gigaspora margarita were incubated with these root exudates, spore germination was only slightly affected but hyphal growth was greatly affected, particularly with exudates from P-deficient plants. This suggests that the P nutrition of host plants influences the composition of root exudates and thereby the hyphal growth of arbuscular mycorrhizal fungi.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005720050106
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  • 3
    Electronic Resource
    Electronic Resource
    One-dimensional shock wave interaction with rubber and low-porosity foam (1995)
    Springer
    Shock waves 5 (1995), S. 25-32 
    Details
    ISSN: 1432-2153
    Keywords: Low-porosity foam ; Shock-foam interaction ; Environmental problem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics , Technology
    Notes: Abstract One-dimensional interaction between a planar shock wave and a rubber or low-porosity foam is investigated experimentally and numerically. The considered polyurethane foam is of high density (ρ c=290 kg/m3) and lowporosity (ϕ=0.76), and this corresponds to an intermediate condition between rubber and high-porosity foam. Stress-strain relations for the low-porosity foam are investigated by machine tests, which show larger deformation against compressive force and higher non-linearity in stress-strain curve as compared with rubber. Also the low-porosity foam shows a hysteresis cycle. Experiments on shock wave-foam interactions are conducted by using a shock tube. Experimental time history of the surface stress of the foam at the end of the shock tube does not show shock type stress increase, but continuous excessive stress rise can be seen, and then dumping vibration approaching to gas dynamic pressure of the reflected shock wave is followed, and the highest stress amounts about 3∼4 times of the pressure after the reflected gas dynamic shock wave. Interactive motions of gas and the low-porosity foam are analyzed using the Lagrangean coordinates system. An elastic model for a low-porosity foam is assumed to be a single elastic material with the measured stress-strain relation. Results of numerical simulations are compared with the shock tube experiments, which show essentially same stress variations with experimental results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02425033
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  • 4
    Electronic Resource
    Electronic Resource
    Glutamate induces Cl− and K+ currents in the olfactory interneurons of a terrestrial slug (1999)
    Springer
    Journal of comparative physiology 184 (1999), S. 553-562 
    Details
    ISSN: 1432-1351
    Keywords: Key words Terrestrial slug ; Procerebrum ; Glutamate receptors ; Quisqualate ; Ibotenate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Glutamate-induced responses in the procerebral neurons of the terrestrial slug Limax marginatus were examined using the nystatin-perforated patch recording technique applied in the voltage-clamp mode and local application of drugs. The procerebrum contains two types of interneurons with different spontaneous activities, bursting and nonbursting neurons. In the bursting neurons, a puff of glutamate evoked a rapidly desensitizing current followed by a smaller sustained current. The reversal potential of the early component showed that the current was mediated by Cl− ions, while the late component was presumed to be mediated by K+ ions. In the nonbursting neurons, glutamate evoked a sustained current with a strong outward rectification, and the current was mediated by K+ ions. Ibotenate selectively evoked the rapidly desensitizing response in the bursting neurons, whereas quisqualate evoked a non-desensitizing K+ current both in the bursting and nonbursting neurons. The glutamate-induced K+ current had similar characteristics with the spontaneous synaptic activities in the procerebrum neurons, suggesting the possibility that glutamate receptors are involved in the spontaneous oscillatory activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003590050355
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  • 5
    Electronic Resource
    Electronic Resource
    Phase advances of circadian rhythms in somatostatin depleted rats: effects of cysteamine on rhythms of locomotor activity and electrical discharge of the suprachiasmatic nucleus (1994)
    Springer
    Journal of comparative physiology 175 (1994), S. 677-685 
    Details
    ISSN: 1432-1351
    Keywords: Circadian rhythm ; Suprachiasmatic nucleus ; Cysteamine ; Somatostatin ; Brain slice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Somatostatin is synthesized in the suprachiasmatic nucleus (SCN), a circadian pacemaker in mammals. To explore the functional significance of somatostatin in the circadian system, we examined rhythms of rat locomotor activity and electrical firing rate of SCN neurons in the brain slice after temporal depletion of somatostatin levels in the SCN. Intraperitoneal administration of cysteamine (200 mg/kg), a somatostatin depletor, significantly reduced somatostatin level in the in vivo SCN 5 min after injection and kept low level as long as 3 to 4 days. This administration, on the other hand, induced significant phase advances of about 51 min in the subsequent free-running rhythm of locomotor activity of the rat. A marked phase advance in the circadian rhythm of firing rate in the SCN was also observed after administration of cysteamine in coronal hypothalamic slices. These persistent phase shifts after administration of a somatostatin depletor may suggest that the change of somatostatin level in the SCN have a feedback influence on the circadian pacemaker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191840
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  • 6
    Electronic Resource
    Electronic Resource
    Genetic determination of antibody specificity (1978)
    Springer
    Naturwissenschaften 65 (1978), S. 616-639 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Notes: Abstract The best system for the study of cell differentiation is a cell which in its differentiated state differs only by one product. This is the case in the immune system. The undifferentiated, but omnipotent stem cell differentiates into a committed B cell which produces only one type of specific antibody out of a million different, genetically fixed possibilities. Gene translocation and fusion is the basis of this differentiation process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401905
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  • 7
    Electronic Resource
    Electronic Resource
    Association of Bone Mineral Density with Polymorphism of the Human Calcium-Sensing Receptor Locus (2000)
    Springer
    Calcified tissue international 66 (2000), S. 181-183 
    Details
    ISSN: 1432-0827
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. A strong correlation between bone mass and genetic factors has been shown in twins and family studies. Some of the genes involved would regulate bone metabolism, bone formation, and resorption, all processes that determine bone mass. One candidate genes, calcium-sensing receptor (CASR) in the parathyroid gland, regulates calcium homeostasis by sensing decreases in extracellular calcium level and effecting an increase in secretion of parathyroid hormone (PTH) and calcium (Ca) reabsorption in the kidney. We have investigated a possible association between the CA-repeat polymorphism at the human CASR gene locus and the bone mineral density (BMD) of radial bone in 472 postmenopausal Japanese women. Genotypes were classified into nine groups according to the number of CA repeats present, from 20 to 12. BMD was expressed as the adjusted BMD, which was the body mass index (BMI), and age-adjusted average BMD. The 247 women who had an A3 allele (228 bp, containing 18 repeats of CA) had significantly lower adjusted BMD (mean ± SD: 0.303 ± 0.059 versus 0.316 ± 0.063 g/cm2; P= 0.0308) than the participants (n = 201) who did not carry an allele of that size. This result suggests that genetic variation at the CASR gene locus is associated with some determinants for BMD in postmenopausal women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005835
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  • 8
    Electronic Resource
    Electronic Resource
    Immuno-electron microscopic localization of fibronectin on rat mast cells (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 495-496 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Rabbit anti-rat plasma fibronectin (pFN) causes histamine release from rat mast cells in the presence of complement. Fibronectin (FN) on rat mast cells, as shown by immuno-electron microscopy, is principally localized on cell folds, so they may play a role of attachment in the matrix of connective tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952657
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  • 9
    Electronic Resource
    Electronic Resource
    Ion upflow and downflow at the topside ionosphere observed by the EISCAT VHF radar (2000)
    Springer
    Annales geophysicae 18 (2000), S. 170-181 
    Details
    ISSN: 0992-7689
    Keywords: Ionosphere (particle acceleration; plasma waves and instabilities) ; Space plasma physics (transport processes)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We have determined the MLT distribution and KpKP dependence of the ion upflow and downflow of the thermal bulk oxygen ion population based on a data analysis using the EISCAT VHF radar CP-7 data obtained at Tromsø during the period between 1990 and 1996: (1) both ion upflow and downflow events can be observed at any local time (MLT), irrespective of dayside and nightside, and under any magnetic disturbance level, irrespective of quiet and disturbed levels; (2) these upflow and downflow events are more frequently observed in the nightside than in the dayside; (3) the upflow events are more frequently observed than the downflow events at any local time except midnight and at any KP level and the difference of the occurrence frequencies between the upflow and downflow events is smaller around midnight; and (4) the occurrence frequencies of both the ion upflow and downflow events appear to increase with increasing KP level, while the occurrence frequency of the downflow appears to stop increasing at some KP level
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-000-0170-3
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  • 10
    Electronic Resource
    Electronic Resource
    Enhancement of protein secretion by optimizing protein synthesis: isolation and characterization of Escherichia coli mutants with increased secretion ability of alkaline phosphatase (1994)
    Springer
    Applied microbiology and biotechnology 41 (1994), S. 163-169 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Overexpression of the Escherichia coli phoA gene, coding for alkaline phosphatase, on multicopy plasmids caused the accumulation of the precursor form of alkaline phosphatase. The cells lost their viability by a half-life of 60 min and exhibited high sensitivity to 1% sodium dodecyl sulfate (SDS), suggesting that the assembly of the surface proteins were affected by overexpression of the phoA gene. From the cells exhibiting resistance to 1% SDS, we obtained 20 mutants that secrete more alkaline phosphatase into the periplasmic space. Three representatives of the mutants accumulated no precursor molecules and secreted alkaline phosphatase by five- to six-fold that of the wild-type cells carrying multicopy phoA. In all of the three mutants, the amount of phoA transcripts were two to four times less than those in the wild-type cells, indicating that the ability to secrete a large amount of alkaline phosphatase was conferred by decreasing the synthetic rates of the phoA gene product. When the promoter of phoA was replaced with the tacI promoter and the expression level of the phoA gene was regulated with isopropyl-1-thio-β-d-galactoside, the secretion of alkaline phosphatase into the periplasm decreased as the synthetic rate of the phoA gene product increased over a threshold. All these results indicate that overproduction of the phoA gene product causes defects in the secretion of alkaline phosphatase and that the regulation of the expression level is essential for efficient translocation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186954
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