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  • Wiley  (1,026)
  • EDP Sciences  (242)
  • Copernicus  (197)
  • Wiley-Blackwell
  • 1
    Electronic Resource
    Electronic Resource
    Trigeminal primary afferent projections to the spinal cord of the frog, Rana ridibunda (1993)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 217 (1993), S. 137-146 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The distribution in the spinal cord of the trigeminal primary projections in the frog Rana ridibunda was studied by means of the anterograde transport of horseradish peroxidase (HRP). Upon entering the medulla via the single trigeminal root, a conspicuous descending tract that reaches the cervical spinal cord segments is established. This projection arises in the ophthalmic (V1), maxillary (V2), and mandibular (V3) trigeminal nerve subdivisions. In the spinal cord, only a minor somatotopic arrangement of the trigeminal fibers was observed, with the fibers arising in V3 terminating somewhat more medially than those from V1 and V2. A dense projection to the medial aspect of the spinal cord, above the central canal, primarily involves V3. Each trigeminal branch sends projections at cervical levels to the contralateral dorsal field, and those from V2 are most abundant. Bilateral experiments with HRP application show convergence of primary trigeminal and spinal afferents within the dorsal field of the spinal cord.The pattern of arrangement of the trigeminal primary afferent fibers in the spinal cord of this frog largely resembles that of amniotes. However, the organization seems simpler and the slight somatotopic distribution of V1, V2, and V3 fibers is similar to the condition in other anamniotes. © 1993 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1052170203
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    Paper (German National Licenses)
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  • 2
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    EARLINET: potential operationality of a research network (2015)
    Copernicus
    Details
    Publication Date: 2015-11-02
    Description: In the framework of ACTRIS (Aerosols, Clouds, and Trace Gases Research Infrastructure Network) summer 2012 measurement campaign (8 June–17 July 2012), EARLINET organized and performed a controlled exercise of feasibility to demonstrate its potential to perform operational, coordinated measurements and deliver products in near-real time. Eleven lidar stations participated in the exercise which started on 9 July 2012 at 06:00 UT and ended 72 h later on 12 July at 06:00 UT. For the first time, the single calculus chain (SCC) – the common calculus chain developed within EARLINET for the automatic evaluation of lidar data from raw signals up to the final products – was used. All stations sent in real-time measurements of a 1 h duration to the SCC server in a predefined netcdf file format. The pre-processing of the data was performed in real time by the SCC, while the optical processing was performed in near-real time after the exercise ended. 98 and 79 % of the files sent to SCC were successfully pre-processed and processed, respectively. Those percentages are quite large taking into account that no cloud screening was performed on the lidar data. The paper draws present and future SCC users' attention to the most critical parameters of the SCC product configuration and their possible optimal value but also to the limitations inherent to the raw data. The continuous use of SCC direct and derived products in heterogeneous conditions is used to demonstrate two potential applications of EARLINET infrastructure: the monitoring of a Saharan dust intrusion event and the evaluation of two dust transport models. The efforts made to define the measurements protocol and to configure properly the SCC pave the way for applying this protocol for specific applications such as the monitoring of special events, atmospheric modeling, climate research and calibration/validation activities of spaceborne observations.
    Print ISSN: 1867-1381
    Electronic ISSN: 1867-8548
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 3
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    EARLINET: potential operationality of a research network (2015)
    Copernicus
    Details
    Publication Date: 2015-07-01
    Description: In the framework of ACTRIS summer 2012 measurement campaign (8 June–17 July 2012), EARLINET organized and performed a controlled exercise of feasibility to demonstrate its potential to perform operational, coordinated measurements and deliver products in near-real time. Eleven lidar stations participated to the exercise which started on 9 July 2012 at 06:00 UT and ended 72 h later on 12 July at 06:00 UT. For the first time the Single-Calculus Chain (SCC), the common calculus chain developed within EARLINET for the automatic evaluation of lidar data from raw signals up to the final products, was used. All stations sent in real time measurements of 1 h of duration to the SCC server in a predefined netcdf file format. The pre-processing of the data was performed in real time by the SCC while the optical processing was performed in near-real time after the exercise ended. 98 and 84 % of the files sent to SCC were successfully pre-processed and processed, respectively. Those percentages are quite large taking into account that no cloud screening was performed on lidar data. The paper shows time series of continuous and homogeneously obtained products retrieved at different levels of the SCC: range-square corrected signals (pre-processing) and daytime backscatter and nighttime extinction coefficient profiles (optical processing), as well as combined plots of all direct and derived optical products. The derived products include backscatter- and extinction-related Ångström exponents, lidar ratios and color ratios. The combined plots reveal extremely valuable for aerosol classification. The efforts made to define the measurements protocol and to configure properly the SCC pave the way for applying this protocol for specific applications such as the monitoring of special events, atmospheric modelling, climate research and calibration/validation activities of spaceborne observations.
    Electronic ISSN: 1867-8610
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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  • 4
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    Solar influence and hydrological variability during the Holocene from a speleothem annual record (Molinos Cave, NE Spain) (2015)
    Wiley
    Details
    Publication Date: 2015-05-22
    Description: We present a multi-proxy approach to reconstructing Holocene climate conditions in northeastern Spain based on an excellent correlation among the lamina thickness, colour parameters and isotope (δ 18 O and δ 13 C) variations recorded in a speleothem. An age model constructed from five U/Th dates and annual lamina counting suggests that the uppermost 14.7 cm of the MO-7 stalagmite grew between 7.2 and 2.5 kyr before present but experienced a growth hiatus from 4.9 to 4.3 kyr. Three spectral analysis methods were applied to 11 time series. The results reveal common solar periodicities on decennial (Gleissberg cycle) and centennial (De Vries-Suess cycle) scales. The onset of Holocene carbonate precipitation in the MO-7 stalagmite appears to be associated with a cold, wet period, whereas the hiatus and the end of growth are related to warm, dry periods. This environmental trend fits well within the regional Holocene climate. This article is protected by copyright. All rights reserved.
    Print ISSN: 0954-4879
    Electronic ISSN: 1365-3121
    Topics: Geosciences
    Published by Wiley
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  • 5
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    Segmentation and kinematics of the North America-Caribbean plate boundary offshore Hispaniola (2015)
    Wiley
    Details
    Publication Date: 2015-10-02
    Description: We explored the submarine portions of the Enriquillo-Plantain-Garden Fault zone (EPGFZ) and the Septentrional-Oriente Fault zone (SOFZ) along the Northern Caribbean plate boundary using high-resolution multi-beam echo-sounding and shallow seismic reflection. The bathymetric data shed light on poorly documented or previously unknown submarine fault zones running over 200 km between Haiti and Jamaica (EPGFZ) and 300 km between the Dominican Republic and Cuba (SOFZ). The primary plate-boundary structures are a series of strike-slip fault segments associated with pressure ridges, restraining bends, step-overs and dogleg offsets indicating very active tectonics. Several distinct segments 50 to 100 km long cut across pre-existing structures inherited from former tectonic regimes or bypass recent morphologies formed under the current strike-slip regime. Along the most recent trace of the SOFZ, we measured a strike-slip offset of 16.5 km, which indicates steady activity for the past ~1.8 Ma if its current GPS-derived motion of 9.8 ± 2 mm/yr has remained stable during the entire Quaternary. This article is protected by copyright. All rights reserved.
    Print ISSN: 0954-4879
    Electronic ISSN: 1365-3121
    Topics: Geosciences
    Published by Wiley
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  • 6
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    IMMUNOLOCALIZATION OF SUBSTANCE P AND NK-1 RECEPTOR IN ADIPOSE STEM CELLS (2017)
    Wiley
    Details
    Publication Date: 2017-05-14
    Description: ABSTRACT Substance P (SP) is a neuropeptide belonging to the thachykinin peptide family. SP, after binding to its receptor, the neurokinin 1 receptor (NK1R), controls several transcription factors such as NF-κB, hypoxia inducible factor (HIF-1α), c-myc, c-fos, c-jun and AP-1. SP and NK1R have a widespread distribution in both the central and peripheral nervous systems. They are also present in cells not belonging to the nervous system (immune cells, placenta, etc.). SP is located in all body fluids, i.e., blood, cerebrospinal fluid, etc., making it ubiquitous throughout the human body. SP and NK1R genes are expressed in the stem cell line TF-1 and in primary stem cells derived from human placental cord blood. However, to our knowledge, the presence of SP and the NK1R receptor in adipose stem cells (ADSC) is unknown. We demonstrated by immunofluorescence the localization of SP and NK1R in human and rat ADSC. SP and NK1R are located in both the cytoplasm and the nucleus of these cells. The NK1R is higher in the nucleus than in the cytoplasm of ADSCs. By Western blot we demonstrated the presence of different isoforms of NK1R that have different subcellular locations in the ADSC. SP induces proliferation and mitogenesis through NK1R in ADSCs. These findings reported here for the first time suggest an important role for a SP/NK1R system, either as genetic and/or epigenetic factor, in both the cytoplasm and nucleus functions of the ADSCs. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 7
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    LGA-newborn from patients with pregestational obesity present reduced adiponectin-mediated vascular relaxation and endothelial dysfunction in fetoplacental arteries (2018)
    Wiley
    Details
    Publication Date: 2018-01-28
    Description: Maternal obesity is associated with large-for-gestational-age (LGA) neonates and programming of obesity-related cardiovascular disease in the offspring, however, the mechanisms that lead to the later are unclear. Presently, interpretations of NO-dependent changes in vascular function in LGA newborn from obese mothers are conflicting. Adiponectin improves endothelial function by increasing eNOS activity and NO production. We propose that LGAs from obese mothers present a diminished vascular response to adiponectin; thus, affecting eNOS and AMPK activation. Chorionic arteries, umbilical cord and primary cultures of umbilical artery endothelial cells (HUAEC) were collected at term (〉38 wks) from uncomplicated singleton pregnancies of LGA and adequate-for-gestational (AGA) newborn. Vascular reactivity of chorionic plate arteries was assessed by wire myography. mRNA expression of adiponectin receptors 1 (AdipoR1) and AdipoR2 in HUAEC was determined by qPCR. Protein expression of AdipoR1, AdipoR2, AMPK, phospho-AMPKα Thr172 , eNOS and phospho-eNOS Ser1177 after stimulation with AdipoRon was determined by Western Blot. Maximal adiponectin-induced chorionic artery relaxation in LGAs was diminished compared to control. In vitro studies showed no differences in expression of AdipoRs, total AMPK and, eNOS activation between groups; however, higher expression of total eNOS and AMPK activation in HUAEC of LGA relative to AGAs were observed. LGA HUAEC showed diminished NO production and eNOS activity compared to AGA in response to AdipoRon but no changes in AMPK activation. Placental endothelium of LGAs shows a diminished vascular response to adiponectin. Moreover, eNOS activation and adiponectin-dependent NO production is lower in HUAEC of LGA from obese mothers, indicating they present dysfuncional placental-endothelial responses. This article is protected by copyright. All rights reserved
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley
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  • 8
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    Macrophage Recruitment Contributes to Regeneration of Mechanosensory Hair Cells in the Zebrafish Lateral Line (2016)
    Wiley
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    Publication Date: 2016-01-12
    Description: In vertebrates, damage to mechanosensory hair cells elicits an inflammatory response, including rapid recruitment of macrophages and neutrophils. While hair cells in amniotes usually become permanently lost, they readily regenerate in lower vertebrates such as fish. Damage to hair cells of the fish lateral line is followed by inflammation and rapid regeneration; however the role of immune cells in this process remains unknown. Here, we show that recruited macrophages are required for normal regeneration of lateral line hair cells after copper damage. We found that genetic ablation or local ablation using clodronate liposomes of macrophages recruited to the site of injury, significantly delays hair cell regeneration. Neutrophils, on the other hand, are not needed for this process. We anticipate our results to be a starting point for a more detailed description of extrinsic signals important for regeneration of mechanosensory cells in vertebrates. This article is protected by copyright. All rights reserved
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley
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  • 9
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    Star-forming galaxies at low-redshift in the SHARDS survey (2019)
    EDP Sciences
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    Publication Date: 2019-01-01
    Description: Context. The physical processes driving the evolution of star formation (SF) in galaxies over cosmic time still present many open questions. Recent galaxy surveys allow now to study these processes in great detail at intermediate redshift (0 ≤ z ≤ 0.5). Aims. We build a complete sample of star-forming galaxies and analyze their properties, reaching systems with low stellar masses and low star formation rates (SFRs) at intermediate-to-low redshift. Methods. We use data from the SHARDS multiband survey in the GOODS-North field. Its depth (up to magnitude ⟨m3σ⟩~ 26.5) and its spectro-photometric resolution (R ~ 50) provides us with an ideal dataset to search for emission line galaxies (ELGs). We develop a new algorithm to identify low-redshift (z 〈 0.36) ELGs by detecting the [OIII]5007 and Hα emission lines simultaneously. We fit the spectral energy distribution (SED) of the selected sample, using a model with two single stellar populations. Results. We find 160 star-forming galaxies for which we derive equivalent widths (EWs) and absolute fluxes of both emission lines. We detect EWs as low as 12 Å, with median values for the sample of ~35 Å in [OIII]5007 and ~56 Å in Hα, respectively. Results from the SED fitting show a young stellar population with low median metallicity (36% of the solar value) and extinction (AV ~ 0.37), with median galaxy stellar mass ~108.5 M⊙. Gas-phase metallicities measured from available spectra are also low. ELGs in our sample present bluer colours in the UVJ plane than the median colour-selected star-forming galaxy in SHARDS. We suggest a new V-J colour criterion to separate ELGs from non-ELGs in blue galaxy samples. In addition, several galaxies present high densities of O-type stars, possibly producing galactic superwinds, which makes them interesting targets for follow-up spectroscopy. Conclusions. We have demonstrated the efficiency of SHARDS in detecting low-mass ELGs (~2 magnitudes deeper than previous spectroscopic surveys in the same field). The selected sample accounts for 20% of the global galaxy population at this redshift and luminosity, and is characterized by young SF bursts with sub-solar metallicities and low extinction. However, robust fits to the full SEDs can only be obtained including an old stellar population, suggesting the young component is built up by a recent burst of SF in an otherwise old galaxy.
    Print ISSN: 0004-6361
    Electronic ISSN: 1432-0746
    Topics: Physics
    Published by EDP Sciences
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  • 10
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    A methodology for investigating dust model performance using synergistic EARLINET/AERONET dust concentration retrievals (2015)
    Copernicus
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    Publication Date: 2015-04-08
    Description: Systematic measurements of dust concentration profiles at continental scale were recently made possible by the development of synergistic retrieval algorithms using combined lidar and sun photometer data and the establishment of robust remote-sensing networks in the framework of Aerosols, Clouds, and Trace gases Research InfraStructure Network (ACTRIS)/European Aerosol Research Lidar Network (EARLINET). We present a methodology for using these capabilities as a tool for examining the performance of dust transport models. The methodology includes considerations for the selection of a suitable dataset and appropriate metrics for the exploration of the results. The approach is demonstrated for four regional dust transport models (BSC-DREAM8b v2, NMMB/BSC-DUST, DREAMABOL, DREAM8-NMME-MACC) using dust observations performed at 10 ACTRIS/EARLINET stations. The observations, which include coincident multi-wavelength lidar and sun photometer measurements, were processed with the Lidar-Radiometer Inversion Code (LIRIC) to retrieve aerosol concentration profiles. The methodology proposed here shows advantages when compared to traditional evaluation techniques that utilize separately the available measurements such as separating the contribution of dust from other aerosol types on the lidar profiles and avoiding model assumptions related to the conversion of concentration fields to aerosol extinction values. When compared to LIRIC retrievals, the simulated dust vertical structures were found to be in good agreement for all models with correlation values between 0.5 and 0.7 in the 1 to 6 km range, where most of dust is typically observed. The absolute dust concentration was typically underestimated with mean bias values of −40 to −20 μg m−3 at 2 km, the altitude of maximum mean concentration. The reported differences among the models found in this comparison indicate the benefit of the systematic use of the proposed approach in future dust model evaluation studies.
    Electronic ISSN: 1867-8610
    Topics: Geosciences
    Published by Copernicus on behalf of European Geosciences Union.
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