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  • 1
    Electronic Resource
    Electronic Resource
    Potentiation of the effects ofSolanum malacoxylon extracts on rat intestinal phosphate and calcium absorption by incubation with ruminal fluid (1978)
    Springer
    Calcified tissue international 26 (1978), S. 215-219 
    Details
    ISSN: 1432-0827
    Keywords: Solanum malacoxylon ; Vitamin D metabolites ; Rickets ; Phosphate ; Calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The effects of a partially purified aqueous extract ofSolanum malacoxylon (SM) leaves and of an SM extract incubated with ruminal fluid (RF) prior to administration on intestinal phosphate and calcium absorption in rachitic rats were compared with 1α, 25-dihydroxy-vitamin D3[1α,25-(OH)2-D3] using a duodenal loop in situ method. The time course responses elicited by both extracts were qualitatively similar to that of 1α, 25-(OH)2-D3. However, a single dose of SMRF was significantly more effective in stimulating32P absorption than an equivalent dose of SM. Part of this difference can be accounted for by incomplete saturation of the phosphate transport system with the level of SM employed. Treatment with rumen potentiated the effects of SM on45Ca absorption to a lesser extent. Extraction of SMRF with nonpolar organic solvents and purification of the lipid extract by chromatography on Silica Gel G thin-layer plates and on Sephadex LH-20 columns yield two fractions which promote intestinal32P absorption. The bioactive fraction eluting first from the Sephadex LH-20 column migrates similarly as 1α,25-(OH)2-D3. The greater effectiveness of SMRF extracts on intestinal phosphate and calcium absorption may be tentatively attributed to the release of 1α,25-(OH)2-D3 from the corresponding glycoside, shown previously to be present in SM, and to steroid modification during incubation with rumen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02013261
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of 1,25-dihydroxycholecalciferol on sarcoplasmic reticulum calcium transport in strontium-fed chicks (1983)
    Springer
    Calcified tissue international 35 (1983), S. 190-194 
    Details
    ISSN: 1432-0827
    Keywords: 1,25-Dihydroxyvitamin D3 ; Calcium transport ; Sarcoplasmic reticulum ; Muscle ; Strontium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Feeding of chicks with strontium, an inhibitor of 1,25-dihydroxycholecalciferol synthesis in kidney, during 7 days, significantly depressed the initial rate of calcium uptake and calcium storing capacity of sarcoplasmic reticulum membranes from skeletal muscle. Oral administration of 1,25(OH)2D3 to strontium-fed animals returned calcium transport values to normal. The changes observed could not be related to differences in the relative proportions of transport ATPase and calcium binding proteins. The results are consistent with a role of 1,25(OH)2D3 in muscle function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405030
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  • 3
    Electronic Resource
    Electronic Resource
    Reversal of decreased phosphorylation of sarcoplasmic reticulum calcium transport ATPase by 1,25-dihydroxycholecalciferol in experimental uremia (1983)
    Springer
    Calcified tissue international 35 (1983), S. 195-201 
    Details
    ISSN: 1432-0827
    Keywords: 1,25-Dihydroxycholecalciferol ; Uremia ; Muscle phosphorylation ; Sarcoplasmic reticulum ; ATPase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary When compared to that from shamoperated controls, sarcoplasmic reticulum isolated from skeletal muscle of uremic rabbits had a lower rate of calcium uptake and storing capacity. In vivo administration of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] restored the values in uremic animals toward normal. To obtain information about the mechanisms responsible for these differences, phosphorylation of the calcium transport ATPase was studied. The steady-state levels of phosphoprotein in uremic membranes were lower and returned to normal when the secosteroid was administered. Electrophoresis of the membranes phosphorylated with32P-inosine triphosphate (32P-ITP) showed that the differences were related to a 100,000 dalton protein. The rate of phosphoprotein formation, determined with32P-ITP and at 0°C, was considerably lower in uremic than in control animals. Pretreatment with 1,25(OH)2D3 prevented this change. The hypothesis is advanced that the vitamin D metabolite affects the steady-state concentration and rate constant of formation of active sites in the Ca-ATPase. These results may partly explain the altered Ca transport function of the sarcoplasmic reticulum in experimental uremia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405031
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of cholecalciferolin vivo on proteins and lipids of skeletal muscle from rachitic chicks (1983)
    Springer
    Calcified tissue international 35 (1983), S. 798-805 
    Details
    ISSN: 1432-0827
    Keywords: Vitamin D deficiency ; Muscle mitochondria ; Actomyosin ; Sarcoplasmic reticulum ; Phospholipids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The protein and lipid constituents of skeletal muscle subcellular fractions isolated from chicks fed a vitamin D-deficient diet for 3 weeks and chicks repleted with cholecalciferol (vitamin D3) were analyzed. Administration of the sterol markedly altered the protein composition of mitochondria. The changes were localized in the inner membranes and consisted of a modification of the relative amounts of proteins of approximate mol wt of 83,000, 58,000, 42,000, and 34,000. In addition, treatment with vitamin D3 modified the distribution pattern of components of the actomyosin contractile complex. An increase in actin and troponin C was particularly noticeable. No differences between rachitic and treated animals were detected in the protein composition of sarcoplasmic reticulum membranes and postmicrosomal soluble fraction. A significant increase in the phospholipid content of sarcoplasmic reticulum (P〈0.05), and to a lesser extent of mitochondria, was observed in repleted chicks. The relative proportions of individual phospholipids, however, were not changed. Injection of an acute dose of cholecalciferol to chicks less severely depleted in vitamin D significantly stimulated the incorporation of32PO4 in vivo to muscle homogenates, mitochondria, and sarcoplasmic reticulum (P〈0.05). As the increases in specific activities of sarcoplasmic inorganic P and membrane lipid P were similar whereas that of serum remained unchanged, the results are compatible with the idea that vitamin D3 stimulates phosphate fluxes across muscle membranes. The sterol produced minor modifications in the fatty acid composition of sarcoplasmic reticulum (P〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405126
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  • 5
    Electronic Resource
    Electronic Resource
    In Vivo Treatment with Calcitriol (1,25(OH)2D3) Reverses Age-Dependent Alterations of Intestinal Calcium Uptake in Rat Enterocytes (1999)
    Springer
    Calcified tissue international 64 (1999), S. 173-178 
    Details
    ISSN: 1432-0827
    Keywords: Key words: 1,25(OH)2D3— Aging — Enterocytes — Calcium uptake — cAMP pathways.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The vitamin D endocrine system has been involved in the impairment of intestinal calcium absorption during aging. Alterations in the nongenomic mechanism of calcitriol (1,25-dihydroxy-vitamin D3; [1,25(OH)2D3] have been recently evidenced. In enterocytes isolated from aged rats, 1,25(OH)2D3 stimulation of Ca2+ channels through the cAMP/PKA pathway is blunted. We have now investigated whether in vivo administration of calcitriol to senescent rats reverses the absence of hormonal effects in isolated intestinal cells. In enterocytes from 20–24-month-old rats given 1,25(OH)2D3 for 3 days (30 ng/100 g bw/day), calcitriol (10−10 M, 3–5 minutes) stimulated Ca2+ uptake and intracellular cAMP to the same degree and protein quinase A (PKA) activity to a lesser degree than in enterocytes from young animals. Significantly higher basal levels of cAMP and PKA detected in enterocytes from old rats were not affected by prior injection of animals with 1,25(OH)2D3. When the aged rats were injected with 25(OH)D3, similar Ca2+ influx, cAMP, and PKA responses to in vitro stimulation with calcitriol were obtained. 1,25(OH)2D3-dependent changes in Ca2+ uptake by enterocytes from both young and old rats treated with calcitriol were totally suppressed by the cAMP antagonist Rp-cAMPS, whereas the response to the agonist Sp-cAMPS was markedly depressed in aged animals. These results suggest that intestinal resistance to nongenomic 1,25(OH)2D3 stimulation of duodenal cell Ca2+ uptake develops in rats upon aging and show that in vivo administration of 1,25(OH)2D3 or its precursor to senescent rats restores the ability of the hormone to stimulate duodenal cell calcium influx through the cAMP messenger system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900598
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  • 6
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    The relationship between pain, analgesics and survival in patients with advanced cancer; a secondary data analysis of the international European palliative care Cancer symptom study. (2019)
    Springer
    Details
    Publication Date: 2019-12-21
    Print ISSN: 0031-6970
    Electronic ISSN: 1432-1041
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 7
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    MAP kinases in proliferating human colon cancer Caco-2 cells (2009)
    Springer
    Details
    Publication Date: 2009-03-20
    Print ISSN: 0300-8177
    Electronic ISSN: 1573-4919
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Springer
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  • 8
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    S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking (2018)
    Cell Press
    Details
    Publication Date: 2018-02-01
    Electronic ISSN: 2211-1247
    Topics: Biology
    Published by Cell Press
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  • 9
    Electronic Resource
    Electronic Resource
    Olivine as an in situ piezometer in high pressure apparatus (1988)
    Springer
    Physics and chemistry of minerals 15 (1988), S. 493-497 
    Details
    ISSN: 1432-2021
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Abstract The deviatoric stress produced in a large-volume, high-pressure apparatus of the girdle-anvil type has been estimated from the density of free dislocations induced in natural olivine single crystals (initial density of 2×106 cm−2). Experiments at maximum pressure P=40 kbar and temperature T=1050°C for t=1 h in NaCl cell assemblies and various P-T paths yield specimens whose dislocation densities are unchanged from this initial value, implying that the deviatoric stress was less than 140 bar. In BN cell assemblies, the recovered specimen from high P-T experiments exhibit much higher densities of dislocations (∼109 cm−2) which have been produced by steady-state plastic deformation of the olivine crystals under a deviatoric stress of ∼3 kbar. This value of deviatoric stress in BN has been corroborated by observations of the subgrain size and recrystallized grain size in specimens of longer run duration (3 h).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311130
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  • 10
    Electronic Resource
    Electronic Resource
    Gulf of Mexico hydrocarbon seep communities (1989)
    Springer
    Marine biology 101 (1989), S. 235-247 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Sediment and water samples were collected by submersible in September 1986 at 16 locations on the carbonate cap overlying a conical diapir, which was formed by the upward migration of oil and gas through a subsurface fault on the continental slope off Louisiana, USA (27°47′N; 91°30.4′W). The biological community at the site was photographed quantitatively with still and video cameras. Rigorous spatial sampling indices were maintained so that variation in chemical parameters and in the abundance of photographed organisms could be estimated within the bounds of the study site. Concentrations of extractable organic material (EOM) ranged from 0.24 to 119.26‰ in the sediment samples, while methane concentrations in the water samples were from 0.037 to 66.474 μM. The visible biological community was predominantly composed of the chemosynthetic tube worms (Vestimentifera) Lamellibrachia sp. and Escarpia sp., and an undescribed, methane-oxidizing mussel (Mytilidae: Bathymodiolus-like), as well as diverse non-chemosynthetic organisms. The ranked abundance of tube worms was significantly correlated (p〈0.05) with the concentration of EOM in the sediment samples, while the abundance of mussels was significantly correlated (p〈0.05) with the concentration of methane in the water samples. Tube worms and mussels both occurred in dense clusters; however, the clusters of mussels had a more restricted distribution within the study site than did clusters of tube worms. Both organisms were most abundant in the vicinity of the subsurface fault.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391463
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