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  • Wiley-Blackwell  (76)
  • Cambridge University Press
Collection
  • 1
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Modern Asian studies 14 (1980), S. 237-271 
    ISSN: 0026-749X
    Source: Cambridge Journals Digital Archives
    Topics: Ethnic Sciences , History , Political Science , Economics
    Notes: Given the system of parliamentary democracy that India developed after its independence in 1947, it is understandable that pluralism came to be the major paradigm used to explain Indian politics. But just as the persistence of economic inequality was instrumental in calling pluralism into question as an appropriate model for explaining the American political system, so the continuation and even increase of inequality in India led social scientists to question the pluralist approach for India. And, as in the American case, a number of scholars turned to a Marxist class analysis to explain the Indian situation; by the mid-1970s a political economy model had begun to take shape that did offer a reason able explanation of the pervasive inequality in India. Also, Mrs Gandhi's Emergency of 1975–1977 fits very easily into this class analysis approach. But then came the elections of 1977 and the ouster of Mrs Gandhi at the polls, an event not explicable in terms of the Marxist model, but which fits very well into the pluralist framework. Which model, then, is more appropriate to employ in accounting for the Indian system ? The best answer seems to be to try to fit the pluralist approach within the Marxist one, with the latter carrying most of the explanatory load.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Bulletin of the British Society for the History of Science 1 (1950), S. 71-72 
    ISSN: 0950-5636
    Source: Cambridge Journals Digital Archives
    Topics: History , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Journal of American studies 3 (1969), S. 177-199 
    ISSN: 0021-8758
    Source: Cambridge Journals Digital Archives
    Topics: English, American Studies , History , Political Science , Sociology , Economics
    Notes: Calvin Coolidge became President on the morning of 3 August 1923. He was to hold that office for five years, six months, and thirty days, during which time he would have a splendid opportunity to secure the destiny of his party. Some of the activities of several of the more seedy characters of the Harding Administration were about to become public knowledge, while the one-interest basis on which Republican power rested was becoming increasingly obvious. In the scandals which followed his accession, Coolidge acquitted himself well, the ‘anti-propaganda’ technique he adopted in fighting the revelations bringing him, it might be argued, an even greater victory at the polls in 1924 than he otherwise would have received. But the party's destiny went well beyond the Twenties, and the success, or lack of it, which would greet the Republicans in the decades beyond depended in large fashion on Coolidge's efforts to pry his party from the rut in which it had firmly planted itself. For by the time Coolidge entered the White House the Republicans had violated a basic canon of practical politics by allowing themselves to become the spokesmen of one interest, to the neglect of those others which, if they ever got together, could easily put an end to Republican dominance. More broadly, the party by this time was a rather exclusive vehicle in which, oblivious to others around them, serenely rode whites, Anglo-Saxons, and Protestants. There were others in this vehicle but by the post-war period they were mostly in the rumble seat, and none too happy about it.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 12 (1970), S. 321-331 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Through the use of pilot plant equipment, transaldolase types I, II, and III (from Candida utilis) have been separated and purified. The procedure includes a time sensitive solvent fractionation below 0°C, ion exchange chromatography, and crystalization. The enzyme yield represents a 41% recovery of crystalline type III and partially purified types I and II.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Osteoclasts mediate acid dissolution of bone for maintenance of serum [Ca2+] and for replacement of old bone in terrestrial vertebrates. Recent findings point to the importance of intracellular signals, particularly Ca2+, in osteoclast regulation. However, acid degradation of bone mineral subjects the osteoclast to uniquely high extracellular [Ca2+]. We hypothesized that this high calcium environment would affect calcium signalling mechanisms, and studied the calcium binding regulatory protein, calmodulin, in the osteoclast. Avian osteoclast bone resorption was inhibited 30% at 1 μM and 90% at 7 μM by the calmodulin antagonist trifluoperazine. Osteoclast bone attachment was not affected by 10 μM trifluoperazine. Quantitative immunofluorescence using fluorescein-labelled calmodulin monoclonal antibody showed a severalfold increase of calmodulin concentration in bone attached relative to plastic attached osteoclasts. Western blots confirmed this, showing two to threefold increased osteoclast calmodulin per milligram of cell protein in 3-day bone-attached vs. nonattached cells. Scanning confocal microscopy showed calmodulin polarization to areas of bone attachment. Electron micrographs with 9nm colloidal gold labelling showed calmodulin in the acid secreting ruffled membrane. ATP-dependent acid transport in osteoclast membrane vesicles was inhibited by the calmodulin antagonist calmidazolium. This effect was reversed by addition of excess calmodulin, showing that the inhibition is specific. Vesicle acid transport inhibition reflects an approximately fourfold shift in the apparent Km for ATP of vesicular acid transport in the presence of the calmodulin antagonist. We conclude that calmodulin concentration and distribution is modified by bone attachment, and that osteoclastic acid secretion is calmodulin regulated. © 1994 Wiley-Liss, Inc.
    Additional Material: 8 Ill.
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  • 6
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science 22 (1956), S. 186-186 
    ISSN: 0022-3832
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 17 (1980), S. 821-831 
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Relationships are formulated to explain the variation in dihydrofolate reductase inhibitory potency for a series of 25 substituted quinazolines, with an antineoplastic potential. Highly significant correlations are obtained using CNDO/2-3R calculated indices and/or the empirically estimated molecular polarizability as independent variables. The MO calculated indices employed are the atomic polarizability, as defined herein, and bond energy. The molecular polarizability is represented by a simple sum of environment independent partial atomic polarizabilities. The partial polarizabilities, reported here for H, C, N, O, F, S, Cl, and Br, are obtained from a multiple regression forced through the origin.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: A free fluid zone electrophoresis experiment was performed in the microgravity environment of Space Shuttle flight STS-3 (March 1983). The experiment was designed to confirm observations made on the Apollo-Soyuz mission of 1975 and to test the effect of high red blood cell (RBC) concentration on free fluid electrophoresis. Photographic documentation of cell zone progression in one-hour separations of mixtures of formaldehyde-fixed human and rabbit erythrocytes (RBC), which were subjected to a field of approximately 13 V cm-1 in low ionic strength buffer, was analyzed. One of two columns contained 2 × 108 RBC ml-1 (low concentration), and the other contained 1 × 109 RBC ml-1 (high concentration). The observed and calculated leading edge displacements of the RBC in the two columns were in agreement, indicating the absence of unexpected effects of the reduced gravity environment. Post-flight analyses of the contents of the columns was not possible, and additional microgravity experiments are needed to evaluate the role of particle-particle interactions in concentrated suspensions undergoing electrophoresis.
    Additional Material: 3 Ill.
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  • 9
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Electron capturing pentafluorobenzyl ester derivatives of prostanoids provide intense negative ion chemical ionization mass spectra. Fragmentation is directed almost entirely away from the prostanoid molecule and this provides intense [M - C6F5CH2]- ions. These ions are ideal for specific and sensitive quantitative selected ion monitoring analysis. The limits of sensitivity employing this technique are in the range 1-8 pg on column compared with 100-500 pg using the corresponding methyl ester derivative in the electron impact mode. The capillary column characteristics of the pentafluorobenzyl esters are suitable for the development of multiprostaglandin gas chromatographic mass spectrometric assays.
    Additional Material: 6 Ill.
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  • 10
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Conditions were established for analyzing as little as 5 pmol of an underivatized peptide delivered in a glycerol sample matrix as a thin film onto a gold-plated copper sample stage and then bombarded with xenon fast atoms. Calibration of the fast atom bombardment high field mass spectrometer and data system was achieved using cesium iodide/glycerol as a reference. Calibration at several accelerating potentials permitted a mass range from 393 to 5941 u. Several factors were examined that contribute to the quality of the mass spectrum: components within the glycerol such as other peptides, alkali salts, acid and reducing agents; the nature of the fast atom gas; concentration of the peptide delivered to the sample stage; and the effect of the sample stage and sample matrix on sensitivity.
    Additional Material: 13 Ill.
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