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  • American Association for the Advancement of Science  (1)
  • Cambridge University Press  (1)
  • 1
    Publication Date: 2019-04-04
    Description: As antibiotic consumption grows, bacteria are becoming increasingly resistant to treatment. Antibiotic resistance undermines much of modern health care, which relies on access to effective antibiotics to prevent and treat infections associated with routine medical procedures. The resulting challenges have much in common with those posed by climate change, which economists have responded to with research that has informed and shaped public policy. Drawing on economic concepts such as externalities and the principal–agent relationship, we suggest how economics can help to solve the challenges arising from increasing resistance to antibiotics. We discuss solutions to the key economic issues, from incentivizing the development of effective new antibiotics to improving antibiotic stewardship through financial mechanisms and regulation.
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2012-03-06
    Description: A Batchelor vortex represents the asymptotic solution of a trailing vortex in an aircraft wake. In this study, an unequal-strength, counter-rotating Batchelor vortex pair is employed as a model of the wake emanating from one side of an aircraft wing; this model is a direct extension of several prior investigations that have considered unequal-strength Lamb–Oseen vortices as representations of the aircraft wake problem. Both solution of the linearized Navier–Stokes equations and direct numerical simulations are employed to study the linear and nonlinear development of a vortex pair with a circulation ratio of$Lambda = ensuremath{-} 0. 5$. In contrast to prior investigations considering a Lamb–Oseen vortex pair, we note strong growth of the Kelvin mode$[ensuremath{-} 2, 0] $coupled with an almost equal growth rate of the Crow instability. Three stages of nonlinear instability development are defined. In the initial stage, the Kelvin mode amplitude becomes sufficiently large that oscillations within the core of the weaker vortex are easily observable and significantly affect the profile of the weaker vortex. In the secondary stage, filaments of secondary vorticity emanate from the weaker vortex and are convected around the stronger vortex. In the tertiary stage, a transition in the dominant instability wavelength is observed from the short-wavelength Kelvin mode to the longer-wavelength Crow instability. Much of the instability growth is observed on the weaker vortex of the pair, although small perturbations in the stronger vortex are observed in the tertiary nonlinear growth phase.
    Print ISSN: 0022-1120
    Electronic ISSN: 1469-7645
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
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