Publication Date:
1999-02-05
Description:
Oligomerization of a peptide was attempted in a flow reactor that simulated a submarine hydrothermal system. When fluid containing glycine repeatedly circulated through the hot and cold regions in the reactor, oligopeptides were made from glycine. When divalent ions (such as copper ions) were added under acidic conditions, oligoglycine was elongated up to hexaglycine. This observation suggests that prebiotic monomers could have oligomerized in the vicinity of submarine hydrothermal vents on primitive Earth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Imai, E -- Honda, H -- Hatori, K -- Brack, A -- Matsuno, K -- New York, N.Y. -- Science. 1999 Feb 5;283(5403):831-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of BioEngineering, Nagaoka University of Technology, Nagaoka 940-2188, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9933163" target="_blank"〉PubMed〈/a〉
Keywords:
Chromatography, High Pressure Liquid
;
Copper/chemistry
;
Diketopiperazines
;
Dimerization
;
*Evolution, Chemical
;
Glycine/*chemistry
;
Glycylglycine/chemical synthesis/chemistry
;
*Hot Temperature
;
Hydrogen-Ion Concentration
;
Hydrolysis
;
Mass Spectrometry
;
Oligopeptides/*chemical synthesis/chemistry
;
Piperazines/chemical synthesis
;
*Pressure
;
Temperature
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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