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  • 1
    Electronic Resource
    Electronic Resource
    Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells (2002)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 44 (2002), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Some strains of the human pathogen Streptococcus pyogenes express a surface protein called protein H, which is released from the streptococcal surface by a cysteine proteinase produced by the bacteria. Here, we find that soluble protein H binds to the surface of lymphocytes and granulocytes, and that the molecule is taken up by lymphocytes and transported to the perinuclear region. The translocation over the cell membrane is rapid, and the uptake and intracellular transportation is not dependent on actin polymerization. Protein H could be immunoprecipitated from cell extracts and nuclear preparations of lymphocytes, and analysis of molecular interactions between pro-tein H and proteins of different cellular compart-ments demonstrated a binding to nucleophosmin/ B23, a protein known to shuttle between the cytoplasm and the nucleus, and to the nuclear proteins SET and hnRNP A2/B1. Nucleophosmin/B23 was co-immunoprecipitated with protein H from cell and nuclear extracts, and binding experiments, including kinetic analyses, suggest that protein H dissociating from nucleophosmin/B23 complexes in the perinuclear region or in the nucleus binds to proteins SET and hnRNP A2/B1. Finally, the uptake and intracellular transportation of protein H was found to result in a cytostatic effect on B and T lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2002.02931.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A symbiosis expressed non-ribosomal peptide synthetase from a mutualistic fungal endophyte of perennial ryegrass confers protection to the symbiotum from insect herbivory (2005)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 57 (2005), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: While much is known about the biosynthesis of secondary metabolites by filamentous fungi their biological role is often less clear. The assumption is these pathways have adaptive value to the organism but often the evidence to support this role is lacking. We provide the first genetic evidence that the fungal produced secondary metabolite, peramine, protects a host plant from insect herbivory. Peramine is a potent insect feeding deterrent synthesized by Epichloë/Neotyphodium mutualistic endophytes in association with their grass hosts. The structure of peramine, a pyrrolopyrazine, suggests that it is the product of a reaction catalysed by a two-module non-ribosomal peptide synthetase (NRPS). Candidate sequences for a peramine synthetase were amplified by reverse transcription polymerase chain reaction. Four unique NRPS products were identified, two of which were preferentially expressed in planta. One of these hybridized to known peramine producing strains. This clone was used to isolate an Epichloë festucae cosmid that contained a two-module NRPS, designated perA. Nine additional genes, which show striking conservation of microsynteny with Fusarium graminearum and other fungal genomes, were identified on the perA-containing cosmid. Associations between perennial ryegrass and an E. festucae mutant deleted for perA lack detectable levels of peramine. A wild-type copy of perA complemented the deletion mutant, confirming that perA is a NRPS required for peramine biosynthesis. In a choice bioassay, plant material containing the perA mutant was as susceptible to Argentine stem weevil (ASW) (Listronotus bonariensis) feeding damage as endophyte-free plants confirming that peramine is the E. festucae metabolite responsible for ASW feeding deterrent activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2005.04747.x
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  • 3
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    Urban climate zone classification using convolutional neural network and ground-level images (2019)
    Sage
    Details
    Publication Date: 2019
    Description: Progress in Physical Geography: Earth and Environment, Ahead of Print. 〈br/〉
    Print ISSN: 0309-1333
    Electronic ISSN: 1477-0296
    Topics: Geography
    Published by Sage
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  • 4
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    Urban climate zone classification using convolutional neural network and ground-level images (2019)
    Sage
    Details
    Publication Date: 2019
    Description: Progress in Physical Geography: Earth and Environment, Ahead of Print. 〈br/〉
    Print ISSN: 0309-1333
    Electronic ISSN: 1477-0296
    Topics: Geography
    Published by Sage
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  • 5
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    Watering our cities: The capacity for Water Sensitive Urban Design to support urban cooling and improve human thermal comfort in the Australian context (2013)
    Sage
    Details
    Publication Date: 2013-01-31
    Description: Urban drainage infrastructure is generally designed to rapidly export stormwater away from the urban environment to minimize flood risk created by extensive impervious surface cover. This deficit is resolved by importing high-quality potable water for irrigation. However, cities and towns at times face water restrictions in response to drought and water scarcity. This can exacerbate heating and drying, and promote the development of unfavourable urban climates. The combination of excessive heating driven by urban development, low water availability and future climate change impacts could compromise human health and amenity for urban dwellers. This paper draws on existing literature to demonstrate the potential of Water Sensitive Urban Design (WSUD) to help improve outdoor human thermal comfort in urban areas and support Climate Sensitive Urban Design (CSUD) objectives within the Australian context. WSUD provides a mechanism for retaining water in the urban landscape through stormwater harvesting and reuse while also reducing urban temperatures through enhanced evapotranspiration and surface cooling. Research suggests that WSUD features are broadly capable of lowering temperatures and improving human thermal comfort, and when integrated with vegetation (especially trees) have potential to meet CSUD objectives. However, the degree of benefit (the intensity of cooling and improvements to human thermal comfort) depends on a multitude of factors including local environmental conditions, the design and placement of the systems, and the nature of the surrounding urban landscape. We suggest that WSUD can provide a source of water across Australian urban environments for landscape irrigation and soil moisture replenishment to maximize the urban climatic benefits of existing vegetation and green spaces. WSUD should be implemented strategically into the urban landscape, targeting areas of high heat exposure, with many distributed WSUD features at regular intervals to promote infiltration and evapotranspiration, and maintain tree health.
    Print ISSN: 0309-1333
    Electronic ISSN: 1477-0296
    Topics: Geography
    Published by Sage
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