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Digitale Medien

GENETIC INFLUENCE ON THE SERUM LEVELS OF NATURALLY OCCURRING HUMAN IGG ANTIBODIES TO DIETARY ANTIGENS: QUANTITATIVE ASSESSMENT FROM A TWIN STUDY (1987)

Husby, S. ; Schultz Larsen, F. ; Petersen, P. Hyltoft

Oxford, UK : Blackwell Publishing Ltd

International journal of immunogenetics 14 (1987), S. 0

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ISSN: 1744-313X

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Biologie , Medizin

Notizen: Serum IgG antibodies to ovalbumin (OA) and beta-lactoglobulin (BLG) were quantified by ELISA techniques in 22 monozygotic (MZ) and 24 dizygotic (DZ) healthy twin pairs. Antibody levels were comparable in the MZ and DZ groups both for anti-OA and anti-BLG antibodies. The genetic variance (ĜWT) was 0.167 for log IgG anti-OA antibodies, and 0·173 for log IgG anti-BLG antibodies, with heritability estimates of 0·44 and 0·37, respectively. No indication was observed of genotype–environmental interaction or differential environmental covariance for the log antibody levels in the MZ and DZ twins. The anti-OA and anti-BLG antibody levels in the same individual correlated only to a low degree. The levels of naturally occurring serum IgG antibodies are significantly influenced by genetic factors.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1744-313X.1987.tb00373.x

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Digitale Medien

Mitochondrial cytochrome b DNA sequence variation of Atlantic cod from Iceland and Greenland (2000)

ÁRnason, E. ; Petersen, P. H. ; Kristinsson, K. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Journal of fish biology 56 (2000), S. 0

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ISSN: 1095-8649

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Biologie

Notizen: Sequence variation of a 250–bp (base pair) fragment of the mitochondrial cytochrome b gene has been studied using polymerase chain reaction and direct sequencing of 519 Atlantic cod Gadus morhua from Iceland and 78 cod from Greenland. Twenty-four variable nucleotide sites, mostly silent, define 34 haplotypes. The amount of variation is high (?C=0·73, π=0·52 per 100 bp) with five haplotypes at polymorphic frequencies in Iceland and a number of widely dispersed rather rare haplotypes. A tree of genetic relationships among haplotypes has considerable homoplasy yet it is relatively shallow implying a high turnover of variants of the polymorphism. Net nucleotide genetic divergences among localities are nil. Geographic locality overall area, and inshore/offshore comparison explain none of the variation in an AMOVA, all the variation is among individuals and a null hypothesis of non-differentiation of haplotype frequencies among localities or overall areas cannot be rejected. A temporal year-class effect is found. The evolutionary difference between Greenland and Iceland cod is not significant and the percentage of variation accounted for by the Greenland/Iceland difference is half of what a temporal effect within Iceland explains. There is no evidence for considering the cod at Greenland and Iceland to consist of separate evolutionary units and the question of separate management units must address the lack of diagnostic genotypes and evidence for gene flow from clinal variation.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1095-8649.2000.tb02115.x

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