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  • 1
    Electronic Resource
    Electronic Resource
    Preliminary evidence that different domains are involved in cytolytic activity and receptor (cholesterol) binding in listeriolysin O, the Listeria monocytogenes thiol-activated toxin (1989)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 65 (1989), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract The inactive truncated 52 Kilodaltons (kDa) Listeriolysin O (LLO) produced by a transposon Tn 1545-induced Listeria monocytogenes non-hemolytic/avirulent mutant previously described (Gaillard et al. (1986) Infect. Immun. 52, 55-55), that lacks a 48 aminoacid fragment at the C-terminal end including the single cysteine residue essential for activity (Mengaud et al. (1988) Infect. Immun. 56, 766–772), bound to the SH-cytolysin membrane receptor cholesterol, as did the active 60 kDa toxin. These results indicate that the missing fragment is a functionally important region needed in the 60 kDa LLo to cause membrane-disruption but not to bind to cholesterol, which strongly suggests that in LLO (and presumably in the other SH-cytolysins, in accordance with their structural and functional homologies) different domains are involved in cytolytic activity and cholesterol binding. The cysteine residue contained in the missing fragment, therefore, would not be essential for cholesterol binding, as in currently thought, rather it seems to be essential specifically for cell lysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1989.tb03603.x
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  • 2
    Electronic Resource
    Electronic Resource
    An Independent Pilot-Scale Fermentation Facility for Recombinant Microorganisms (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 646 (1991), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1991.tb18600.x
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  • 3
    Electronic Resource
    Electronic Resource
    PRESENT STATUS OF HYDROCORTISONE AS A THERAPEUTIC AGENT IN RHEUMATOID ARTHRITIS (1955)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 61 (1955), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1955.tb42484.x
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  • 4
    Electronic Resource
    Electronic Resource
    THERMAL DISCHARGES AND PUBLIC POLICY DEVELOPMENT (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 8 (1972), S. 0 
    Details
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: The generation of electric energy in steam-electric power plants is accompanied by the discharge of large quantities of waste heat into the environment. In most cases, this heat is released into natural bodies of water at temperatures relatively close to ambient. In certain locations, such as the Chesapeake Bay, discharges of waste heat may triple in the next decade. It is expected that past practices of thermal discharge, if continued into the future, will result in significant damages to other legitimate users of the water resource, both present and future. This paper reviews the economic causes of these potential damages, and describes the role of public policy as one of removing such causes through regulation incentive or intervention. Possible public policies are reviewed, including prohibition, standards, various types of dollar incentives such as taxes and subsidies, marketable effluent permits, and direct government investment. The innovative power plant siting program recently adopted in Maryland is also discussed. It is concluded that no statements can be made regarding the comparative efficiency or effectiveness of the various policies at the present state of knowledge. It is recommended that policy-makers adopt mixed strategies, preserving as many options as possible for dealing with similar problems in the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-1688.1972.tb05167.x
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  • 5
    Electronic Resource
    Electronic Resource
    A SYSTEMS STUDY OF STORM RUNOFF PROBLEMS IN A NEW TOWN (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 6 (1970), S. 0 
    Details
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: A system study was conducted on the use of a large number of small reservoirs dispersed throughout an urban community as a means of storm water pollution control. The study was based on an area within the “new city” of Columbia, Maryland. Water collected and stored in the reservoirs is treated for release or use in meeting sub-potable and potable water demands in the community. Design and performance criteria were developed for such a system. A simulation model and a computerized evaluation technique were used to select the optimal locations and system configurations. The results of this study indicated that such a system would be less expensive than a conventional engineering approach to storm water pollution control. Further, the benefits derived from use of the storm water as a water supply can offset a portion of the cost of pollution control. Several secondary benefits also result from this concept including erosion and sediment control, storm flow dampening, and recreational facilities. A program is now underway to demonstrate this concept in Columbia, Maryland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-1688.1970.tb01655.x
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  • 6
    Electronic Resource
    Electronic Resource
    REPLY TO DISCUSSION by Lee Wilson and Ron Luke (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 26 (1990), S. 0 
    Details
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-1688.1990.tb01408.x
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  • 7
    Electronic Resource
    Electronic Resource
    FORECASTING URBAN WATER USE: THE IWR-MAIN MODEL (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 25 (1989), S. 0 
    Details
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: : In the current forecasting practice, future water requirements of a growing urban area are often represented as the product of the number of people to be served by the water system and an assumed quantity of gross per capita water use. This paper describes a forecasting approach that differs from the per capita method in two important aspects. First, it disaggregates urban water use into a large number of categories, each consisting of a relatively homogeneous group of water users. Second, it links water use in each category to factors that determine both the need for water as well as the intensity of water use. This approach is incorporated into a computerized forecasting system referred to as IWR-MAIN. The advantages of the IWR.MAIN model over the traditional per capita method are illustrated in a case study of Anaheim, California.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-1688.1989.tb05670.x
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  • 8
    Electronic Resource
    Electronic Resource
    MYTH AND TECHNOLOGY IN THE AMERICAN ACCOUNTING PROFESSION (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of management studies 19 (1982), S. 0 
    Details
    ISSN: 1467-6486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The American accounting profession attempts to provide the public with efficient and effective financial reports; but to succeed, it must satisfy an environment of diverse, often conflicting, institutions. This article critically interprets the profession's development, arguing that it displays an interplay of myth and technology. This interplay generates structural flaws in the profession as well as a bias against reform.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6486.1982.tb00063.x
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  • 9
    Electronic Resource
    Electronic Resource
    On the Efficient Use of Mathematics in Economics: Some Theory, Facts and Results of an Opinion Survey (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Kyklos 39 (1986), S. 0 
    Details
    ISSN: 1467-6435
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Sociology , Economics
    Notes: We consider mathematics to be an input into the production of human and knowledge capital in economics. The competitive and the interest group models are analyzed as to their predictions about the efficient use of this input. Many stylized facts are found to be consistent with the interest group model and the implication of an excess use of mathematics. Mathematics in journal articles is shown to have grown significantly during the postwar years. In a survey, 250 economists express the view that there is too much mathematics in professional journals. Only a minority of respondents rejects the view that interest group behaviour is taking place.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6435.1986.tb00779.x
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  • 10
    Electronic Resource
    Electronic Resource
    Mediation of sterol-induced calmodulin synthesis in Phaseolus vulgaris roots by Ca2+ and its possible relationship to plant growth regulators (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 75 (1989), S. 0 
    Details
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Vitamin D3 and stigmasterol have been previously shown to stimulate growth, Ca2+ fluxes and calmodulin synthesis in Phaseolus vulgaris roots. In this study, these sterols (10−9M) were shown to accelerate the incorporation of [3H]-thymidine into DNA in Phaseolus vulgaris (L. cv. Contraancha) root apices, similarly to a mixture of the mitogenic plant growth factors 2,4-dichlorophenoxyacetic acid and kinetin (4.6 μM each). The effects of stigmasterol were blocked by flufenazine, a calmodulin antagonist. Analogously to stigmasterol, the plant hormones stimulated calmodulin synthesis as shown by double labeling of root proteins with [14C]-leucine and [3H]-leucine, respectively, followed by their separation on sodium dodecyl sulfate-po-lyacrylamide gels and a calmodulin affinity column, immunoblot analysis and cyclic AMP phosphodiesterase activation assays. The stimulation of root calmodulin formation by stigmasterol was abolished in the absence of Ca2+ in the incubation medium and was mimicked by the Ca2+ ionophore A–23187. The results suggest that the sterols, like plant mitogenic hormones, promote DNA synthesis, and that these compounds stimulate calmodulin synthesis as a consequence of their mitogenic activity. Ca2+ appears to mediate the action of the sterols.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3054.1989.tb05615.x
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