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  • 1
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    Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening (2017)
    Springer Nature
    Details
    Publication Date: 2017-09-27
    Print ISSN: 0021-8820
    Electronic ISSN: 1881-1469
    Topics: Chemistry and Pharmacology , Medicine
    Published by Springer Nature
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  • 2
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    Initial defensive secretory compounds emitted from the live millipede and the induction of apoptotic cell death (2021)
    Springer Nature
    Details
    Publication Date: 2021-04-15
    Description: The initial defensive secretory compounds emitted from a live millipede have not yet been clarified. This study focused on elucidating the initial secretory compounds emitted from a live millipede. Pre-concentration of the defensive secretory volatile organic compounds (VOC) from the live Polidesmida millipedes, Chamberlinius hualienensis and Oxidus gracilis, was performed using a three-stage VOC concentration technique by an on-line GC/MS system. As a result, the monoterpenes derived from the plant metabolite; i.e., α-pinene, α-thujene, β-pinene, 3-carene, β-myrcene, β-phellandrene, γ-terpinene, o,m,p-cymenes, limonene and camphene were first detected as the initial secretory substances. It was elucidated that some plant monoterpenes have a repellent effect and antifungal and antibacterial actions which are used as defensive substances. In addition, this study also confirmed that these monoterpenes induced apoptotic cell death involved in the induction of the caspase 3/7 activity. The millipede feeds on fallen or withered leaves containing the monoterpenes. Thus, the millipede accumulates the plant defensive secretions in the exocrine defense glands of the body somites, which would be used as against predators.
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 3
    Electronic Resource
    Electronic Resource
    Role of rpoS in the regulation of Salmonella plasmid virulence (spv) genes (1994)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 123 (1994), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Salmonella plasmid virulence (spv) genes are organized into two transcriptional units: one formed by the spvR gene and the other by the spvA, spvB, spvC and spvD genes. Transcription of both units is activated by SpvR, a regulatory protein of the LysR family. The effect of RpoS, a stationary phase-associated sigma factor, on the expression of spv genes was studied using lacZ transcriptional fusions to spvR and spvA in wild-type and rpoS Escherichia coli backgrounds. Mutant and wild-type SpvR proteins were expressed in trans from a multicopy plasmid. The results show that the combined action of rpoS and spvR is necessary for transcription of spvA and that this combination also enhances transcription of spvR. Interestingly, spvR can also be transcribed in an alternative manner, i.e. in the absence of rpoS or spvR or both. The possible role for SpvR as a repressor of its own transcription is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1994.tb07211.x
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  • 4
    Electronic Resource
    Electronic Resource
    Amino-terminal sequence analysis of four plasmid-encoded virulence-associated proteins of Salmonella typhimurium (1991)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 77 (1991), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: We have expressed four virulence-associated proteins encoded by the Salmonella typhimurium plasmid pEX102 in Escherichia coli. The genes coding for the proteins MkaA, MkaB, MkaC and MkaD subcloned in the vectors pUC19 or Bluescript KS+ directed substantial production of these proteins in E. coli. The same host harbouring pEX102 did not produce these proteins in detectable amounts. The proteins were exclusively found in the particulate fraction. The amino-terminal sequence analysis showed that the N-termini of these proteins corresponded to the ones predicted from the open reading frames found previously in the DNA sequence of the virulence determinant and that no N-terminal signal sequence processing of the proteins occurred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1991.tb04369.x
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  • 5
    Electronic Resource
    Electronic Resource
    Production and secretion of pertussis toxin subunits in Bacillus subtilis (1990)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 68 (1990), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Pertussis toxin (PT) is a major component of today's acellular whooping cough vaccines. The use of cellular vaccines is predicted to increase sharply in the near future. There is therefore a need to produce PT in a way that makes its purification as easy as possible. Our approach was to express all five PT subunits individually in Bacillus subtilis. We have used vectors containing the promoter and signal sequences of the α-amylase gene of Bacillus amyloliquefaciens followed by an insert encoding the appropriate PT-subunit. All PT-subunits were secreted and found in the culture supernatant. The level of expression varied considerably: S1 and S5 were produced in large quantities whereas much smaller amounts of S2, S3 and S4 were found. The subunits were also present in the membrane fraction of the respective strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1990.tb04138.x
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  • 6
    Electronic Resource
    Electronic Resource
    Imidazoline and Adrenoceptor Involvement in Cardiovascular Responses to Clonidine in Sham and Sinoaortic Denervated Rats (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 763 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb32451.x
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  • 7
    Electronic Resource
    Electronic Resource
    Transcriptional regulation of Salmonella enterica virulence plasmid genes in cultured macrophages (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 10 (1993), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The plasmid-carried spv genes promote virulence of salmonellae in mice by allowing bacterial growth in the reticuloendothelial tissue. When the bacteria are cultivated under normal laboratory conditions the spv genes appear dormant. This communication explores the transcriptional regulation of spv genes within murine macrophage-like J774-A.1 cells utilizing a new reporter system. Transcriptional fusions were constructed between promoter elements of the Salmonella enterica var. Typhimurium spv genes and the KS71A fimbrial gene cluster. The expression of KS71A fimbriae In fusion-carrying Escherichia coli strains was found to be under the control of the transcriptional activator gene spvR. In strains overproducing SpvR, KS71A fimbriae were assembled on the bacterial cell surface and could be detected by bacterial agglutination or immunofluorescence of intact bacteria; the reporter activity was quantified by estimating the percentage of fluorescent bacteria and by immunoblotting of cell lysates. The activity of the reporters, when transformed into the parent Typhimurium TML R66, was low and revealed less than 0.3% fimbriated cells under in vitro culture conditions. A 15–30-fold increase in fimbriation was observed when the bacteria were cultivated within J774-A.1 cells. No such increase occurred when the reporter fusions were transformed into TML R66 cured of the virulence plasmid. Insertional inactivation of the spvR gene of the virulence plasmid in Typhimurium TML R66 also abolished induction, whereas corresponding inactivation of spvA or spvB did not reduce induction. No increase in reporter activity was obtained in Typhimurium of line Q1, which is naturally avirulent for mice, although the strain was provided with virulence plasmid pEX102 of line TML R66. We conclude that the intracellular environment of J774-A.1 cells induces the spv genes and that this induction requires gene functions of both the bacterial chromosome and the virulence plasmid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1993.tb00902.x
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  • 8
    Electronic Resource
    Electronic Resource
    Editorial (1995)
    Oxford, UK : Blackwell Publishing Ltd
    The @island arc 4 (1995), S. 0 
    Details
    ISSN: 1440-1738
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1738.1995.tb00139.x
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  • 9
    Electronic Resource
    Electronic Resource
    Anomalous structural evolution of the Shimanto Accretionary Prism at Murotomisaki, Shikoku Island, Japan (1992)
    Oxford, UK : Blackwell Publishing Ltd
    The @island arc 1 (1992), S. 0 
    Details
    ISSN: 1440-1738
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Abstract The Late Oligocene-Early Miocene Nabae Sub-belt of the Shimanto Accretionary Prism was created coevally (ca 25-15 Ma) with the opening of the Shikoku back-arc basin, located to the south of the southwest Japan convergent margin. The detailed geology of the sub-belt has been controversial and the interaction of the Shimanto accretionary prism and the opening of the Shikoku Basin has been ambiguous. New structural analysis of the sub-belt has led to a new perception of its structural framework and has significant bearing on the interpretation of the Neogene tectonics of southwest Japan.The sub-belt is divided into three units: the Nabae Complex; the Shijujiyama Formation; and the Maruyama Intrusive Suite. The Nabae Complex comprises coherent units and mélange, all of which show polyphase deformation. The first phase of deformation appears to have involved landward vergent thrusting of coherent units over the mélange terrane. The second phase of deformation involved continued landward vergent shortening. The Shijujiyama Formation, composed mainly of mafic volcanics and massive sandstone, is interpreted as a slope basin deposited upon the Nabae Complex during the second phase of deformation. The youngest deformational pulse involved regional flexing and accompanying pervasive faulting. During this event, mafic rocks of the Maruyama Intrusive Suite intruded the sub-belt. Fossil evidence in the Nabae Complex and radiometric dates on the intrusive rocks indicate that this tectonic scheme was imprinted upon the sub-belt between ∼23 and ∼14 Ma.The timing of accretion and deformation of the sub-belt coincides with the opening of the Shikoku Basin; hence, subduction and spreading operated simultaneously. Accretion of the Nabae Sub-belt was anomalous, involving landward vergent thrusting, magmatism in newly accreted strata and regional flexing. It is proposed that this complex and anomalous structural history is largely related to the subduction of the active Shikoku Basin spreading ridge and associated seamounts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1738.1992.tb00065.x
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  • 10
    Electronic Resource
    Electronic Resource
    Editorial (1993)
    Oxford, UK : Blackwell Publishing Ltd
    The @island arc 2 (1993), S. 0 
    Details
    ISSN: 1440-1738
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1738.1993.tb00079.x
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