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  • Nature Publishing Group  (2)
  • Blackwell Publishing Ltd  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The D1 Agonist Dihydrexidine Releases Acetylcholine and Improves Cognition in Rats (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 777 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Neurochemical and behavioral studies have elucidated extensive interactions between dopaminergic and cholinergic systems in brain areas associated with movement and cognition. The initial goal of these studies was to evaluate the effect of the anti-Parkinson drug dihydrexidine (DHX), a dopamine D1 full-efficacy agonist, on brain acetylcholine (ACh) release using in vivo microdialysis techniques. Moderate doses of DHX (3 and 10 mg/kg) produced approximately a 50% increase in striatal ACh release that was blocked by the D1 agonist SCH23390 (0.3 mg/kg). A higher dose of DHX (17.5 mg/kg) was less effective in raising striatal ACh, possibly due to D2 receptor activation. In frontal cortex, DHX (10 mg/kg) evoked a more robust increase in ACh release (+ 200%) that was blocked by SCH23390 (0.3 mg/kg). Since elevations in brain ACh are associated with cognitive improvement, the effectiveness of DHX in a passive avoidance model of learning and memory was also evaluated. These studies revealed a significant improvement in performance by 0.3 mg/kg DHX in scopolamine-induced amnestic rats. These results provided support for the hypothesis that DHX improves cognitive performance as a consequence of ACh release in relevant brain regions. Further, D1 agonists may have novel therapeutic potential in the treatment of dementia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb34457.x
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  • 2
    Electronic Resource
    Electronic Resource
    The Hubble constant as derived from 21 cm linewidths (1984)
    [s.l.] : Nature Publishing Group
    Nature 307 (1984), S. 326-329 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The IR 21 cm linewidth–absolute magnitude relation is calibrated by means of local galaxies with known distances, including new distance determinations of M33 and M81. The calibrated relation is applied to 17 Virgo cluster galaxies of type Sab to Sd and yields a cluster modulus of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/307326a0
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  • 3
    Electronic Resource
    Electronic Resource
    Isaac Newton Telescope (1969)
    [s.l.] : Nature Publishing Group
    Nature 222 (1969), S. 1210-1211 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR,-An editorial in Nature (222, 211; 1969) is critical of the management of the Isaac Newton reflector. We do not wish to comment on that, which is purely a national matter, but we cannot ignore the unrealistic description given by your anonymous editorial writer on the way successful ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2221210b0
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