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  • 1
    Electronic Resource
    Electronic Resource
    The Role of Arachidonic Acid in the Secretion of the Amyloid Precursor Protein (APP) (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 777 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: We have studied the activation of human ml-muscarinic receptors in a genetically engineered Chinese hamster ovary cell line (CHO-ml) to determine which second messenger systems affect the secretion of APP via the non-amyloidogenie route. Carbachol activation of the signaling pathways in CHO-ml cells promotes APP secretion by activation of both protein kinase C (PKC)-dependent or Ca++ -dependent second messenger pathways. Both pathways converge to increase the enzyme activity of phospholipase A2 (PLA2), the enzyme that releases arachidonic acid from cellular stores. Directly activating PLA2 with melittin, a peptide from bee venom, or by adding arachidonic acid directly to cultured cells increases the secretion of APP. Thus, our results indicate that arachidonic acid is yet another cellular second messenger involved in regulating the metabolism of APP in addition to PKC and cytoplasmic Ca++. Moreover, activation of PLA2 appears to be an obligatory event in increasing the secretion of APP from CHO-ml cells by the various methods of activation that we have tried thus far.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb34438.x
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  • 2
    Electronic Resource
    Electronic Resource
    Impact of some process variations on NiFe thin films (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 4195-4197 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Rutherford backscattering spectrometry (RBS) and Auger electron spectroscopy (AES) are used to detect changes in stoichiometry and impurity incorporation in thin, rf diode sputtered NiFe films as a function of processing variations. Comparisons are made to thin, evaporated NiFe films with respect to oxygen reactivity. Because Ni and Fe are close in atomic weight, RBS, using 2-MeV He incident ions, cannot resolve them. However, by increasing the He incident energy to 4.7 MeV, the (26)Fe(56) and (28)Ni(58) isotopes are resolvable in films thinner than about 250 A(ring) and the actual NiFe thin-film stoichiometry can be calculated. Complementary AES depth profiling measurements indicate Fe enrichment by approximately 5 wt. % as the deposition substrate bias is increased from 0 to −200 V. Magnetic characterization shows a corresponding increase in easy-axis coercivity of more than a factor of 10. Other magnetic parameters are also adversely affected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.334609
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  • 3
    Electronic Resource
    Electronic Resource
    Coercivity, structure, and stoichiometry of Permalloy/alumina multilayers (1985)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 57 (1985), S. 4192-4194 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A series of permalloy/alumina multilayers were examined to determine their structure, composition, and magnetic performance. The conditions of permalloy and alumina-layer thickness, and substrate bias necessary to minimize the coercivity have been shown. Multilayer structures with alumina-layer thicknesses of less than 100 A(ring) and permalloy-layer thicknesses between 400 and 500 A(ring) had the lowest coercivities. Structures were examined by RBS, TEM, AES, and XRD to study the effect of bias sputtering on the structure and composition of the multilayers. It was found that sputtering multilayers at high biases did not affect the coercivity, but did cause significant physical and chemical changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.334608
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  • 4
    Electronic Resource
    Electronic Resource
    Bacterial Ingestion by the Rumen Ciliates Entodinium and Diplodinium (1959)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 6 (1959), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS. In cattle fed a high-starch diet, species of Entodinium and Diplodinium ingested associated ruminal bacteria. Stained preparations of diluted rumen contents showed Entodinium caudatum, E. minimum, E. dubardi, (syn. E. simplex), E. longinucleatum, E. bursa, E. nanellum, E. exiguum, and E. vorax contained gram-positive diplococci. Starch grains with adherent gram-positive diplococci were observed within Entodinium spp. Diplodinium ecaudatum forma ecaudatum, D. ecaudatum forma caudatum, D. neglectum and an unidentified species of Diplodinium also ingested ruminal diplococci. Bacteria were isolated from mixed species of Entodinium by washing and culturing the protozoa in a starch feed-extract agar medium. The strains isolated from the ciliates were gram-positive diplococci, 0.8 times 1–1.5 μm, which attached themselves to starch granules and were able to digest the starch. Conclusive evidence of bacterial ingestion by the oligotrichs was obtained by providing the bacterial cultures to Entodinium species (E. dubardi and E. minimum) which had been starved 24 hr. Gram-stained preparations showed the ciliates readily ingested the bacteria. The amylolytic cocci utilized by Entodinium spp. were identified as Streptococcus bovis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1959.tb04361.x
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  • 5
    Electronic Resource
    Electronic Resource
    Hyperthermia Potentiates the Activity of Immunotoxin Conjugates against Common Acute Lymphoblastic Leukaemia Cells in Vitro (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 511 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb36272.x
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