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  • 1
    Electronic Resource
    Electronic Resource
    GENETIC VARIATIONS IN THE ACETYLATION OF ISONIAZID AND OTHER DRUGS (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 151 (1968), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1968.tb48255.x
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  • 2
    Electronic Resource
    Electronic Resource
    GENETIC VARIATIONS IN THE ACETYLATION OF ISONIAZID AND OTHER DRUGS (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 151 (1968), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1968.tb11933.x
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  • 3
    Electronic Resource
    Electronic Resource
    INDIVIDUAL VARIATIONS OF DRUG METABOLISM AS A FACTOR IN DRUG TOXICITY (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 123 (1965), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1965.tb12255.x
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  • 4
    Electronic Resource
    Electronic Resource
    The rfb locus from Pseudomonas aeruginosa strain PA103 promotes the expression of O antigen by both LPS-rough and LPS-smooth isolates from cystic fibrosis patients (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 13 (1994), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: SummaryStrains of Pseudomonas aeruginosa initially isolated from patients with cystic fibrosis (CF) often express a smooth lipopolysaccharide (LPS) containing many long O side-chain antigens, but once a chronic infection is established, strains recovered from these patients express little or no LPS O antigen. The genetic basis for this loss of O antigen expression by P. aeruginosa CF isolates is unknown. We report here that 20 CF isoiates of P. aeruginosa, 13 of which are LPS-rough, were each capable of expressing serogroup 011 antigen when provided with the rfb iocus from P. aeruginosa serogroup 011 strain PA103 on the recombinant plasmid pLPS2. Eight of the thirteen LPS-rough isolates co-expressed another, presumably endogenous, O antigen when they contained pLPS2. Different subcloned regions of pLPS2 complemented distinct strains to restore endogenous O antigen expression. These data suggest that the loss of O antigen expression by P. aeruginosa CF isolates results from alterations specific to the rfb region, and is not due to mutations involving other loci or ancillary LPS genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1994.tb00437.x
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  • 5
    Electronic Resource
    Electronic Resource
    Assessing Potential for Aquaculture Development with a Geographic Information System (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the World Aquaculture Society 21 (1990), S. 0 
    Details
    ISSN: 1749-7345
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Comprehensive analyses of aquaculture potential are required for policy formulation and planning for aquaculture development. A computer-automated geographical information system (CIS) was assessed as a tool to analyze the complex spatial and attribute data sets needed to locate aquaculture potential. The state of Louisiana, USA, was the study area. Areas for the further development of catfish and crawfish culture and crawfish-rice and crawfish-grain sorghum double cropping were identified. The CIS showed that there were ample opportunities for the expansion of catfish farming on flatlands based on soil suitability and length of the growing season. Parishes in which crawfish are already raised occupy most of the best suited soils and include those with the longest growing seasons. The potential to further integrate crawfish with rice and with grain sorghum in double cropping systems was good. The results demonstrated that a GIS can be used to aid large-area aquacultural development planning.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-7345.1990.tb00535.x
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  • 6
    Electronic Resource
    Electronic Resource
    Calmodulin-stimulated calcium pumping ATPases located at higher plant intracellular membranes: a significant divergence from other eukaryotes? (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 90 (1994), S. 0 
    Details
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The plasma membrane (PM) of all eukaryotes so far investigated contains a P-type Ca2+-pumping ATPase responsible for maintaining low cytosolic free calcium concentrations. In animal cells this has been shown to be a type of Ca2+-pump which is directly stimulated by binding the calcium-dependent regulator protein calmodulin. These PM Ca2+-pumps have been named ‘PM-type’ as they appear to be exclusively located at the PM and not in intracellular membrane (IM) fractions. Recent progress on higher plant cells reveals that they possess calmodulin-stimulated Ca2+-pumps of the ‘PM-type’. However, these calmodulin-stimulated Ca2+-pumps appear to be located not only at the PM but also in intracellular membranes, probably the endoplasmic reticulum (ER). The evidence is also convincing that these IM-located Ca2+-pumps are directly stimulated by calmodulin (possess a calmodulin-binding region) and are true ‘PM-type’ Ca2+-pumps. This appears to represent a marked divergence between plant and animal cell Ca2+-pumps. Recently, molecular cloning has revealed that plant cells also contain a Ca2+-pump which is not directly stimulated by calmodulin and which strongly resembles the mammalian ER/SR type of Ca2+-pump. The significance of these findings for plant cell function is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3054.1994.tb00408.x
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  • 7
    Electronic Resource
    Electronic Resource
    Cell-cycle mutations among the collection of Saccharomyces cerevisiae dna mutants (1994)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 116 (1994), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract The temperature-sensitive dna mutants of the budding yeast Saccharomyces cerevisiae (Dumas et al. (1982) Mol. Gen. Genet. 187, 42–46) are more inhibited in DNA synthesis than in protein synthesis. These properties are also characteristics of many yeast mutations that inhibit progress through the cell cycle. Therefore we surveyed the collection of dna mutants for cell-cycle mutations. By genetic complementation we found that dna1 = cdc22, dna6 = cdc34, dna19 = cdc36, and dna39 = dbf3. Furthermore, by direct gene cloning we found that the dna26 mutation is allelic to prt1 mutations, which are known to exert primary inhibition on protein synthesis. This protein-synthesis mutation exerts a dna phenotype due to cell-cycle inhibition: prt1 mutations can block the regulatory step of the cell cycle while allowing significant amounts of protein synthesis to continue. Our non-exhausive screening suggests that the dna mutants may house other mutations that affect the yeast cell cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1994.tb06693.x
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