Publication Date:
2014-01-18
Description:
An operationally simple protocol for the synthesis of 2,3-dihydrobenzo[ f ][1,4]oxazepin-3-ones, based on an Ugi reaction of an ortho -(benzyloxy)benzylamine, glycolic acid, an isocyanide and an aldehyde, followed by an intramolecular Mitsunobu substitution was developed. The required ortho -(benzyloxy)benzylamines have been in situ generated from the corresponding azides, in turn prepared in high yields from salicylic derivatives. Beilstein J. Org. Chem. 2014, 10, 209–212. doi:10.3762/bjoc.10.16
Keywords:
benzoxazepinesdiversity-oriented synthesismulticomponent reactionsMitsunobu reactionUgi reaction
Electronic ISSN:
1860-5397
Topics:
Chemistry and Pharmacology
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