Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Cell and Developmental Biology
18 (2002), S. 193-219
ISSN:
1081-0706
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Biology
,
Medicine
Notes:
Abstract Spindle microtubules interact with mitotic chromosomes, binding to their kinetochores to generate forces that are important for accurate chromosome segregation. Motor enzymes localized both at kinetochores and spindle poles help to form the biologically significant attachments between spindle fibers and their cargo, but microtubule-associated proteins without motor activity contribute to these junctions in important ways. This review examines the molecules necessary for chromosome-microtubule interaction in a range of well-studied organisms, using biological diversity to identify the factors that are essential for organized chromosome movement. We conclude that microtubule dynamics and the proteins that control them are likely to be more important for mitosis than the current enthusiasm for motor enzymes would suggest.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.cellbio.18.032002.132412
Permalink
|
Location |
Call Number |
Expected |
Availability |