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  • American Society of Hematology  (2)
  • Springer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Studies on the effect of dry Sundakai (solanum torvum) powder supplementation on lipid profile, glycated proteins and amino acids in non-insulin dependent diabetic patients (1992)
    Springer
    Plant foods for human nutrition 42 (1992), S. 175-182 
    Details
    ISSN: 1573-9104
    Keywords: Diabetes mellitus ; dry Sundakai powder supplementation ; glucose ; lipid profile ; glycated proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The effect of dry Sundakai powder supplementation (7 g providing 1.23 g of crude fibre) on glycemic control, lipidemic control, total amino acids and uronic acid was studied on 30 non-insulin dependent diabetes mellitus patients. All the patients were on hypoglycemic drugs. The above parameters were monitored at day 1, 15 and 30 days. After one month of fibre supplementation, no significant changes were observed with respect to glucose, lipid profile, glycated proteins, total amino acids and uronic acid levels in these subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02196470
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Manufacture and Properties of Erythromycin Beads Containing Neutron-Activated Erbium-171 (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 264-269 
    Details
    ISSN: 1573-904X
    Keywords: neutron activation ; erbium-171 ; erythromycin ; drug delivery system ; gamma scintigraphy ; radiolabeled dosage forms ; scanning electron micrography ; erythromycin dissolution ; erythromycin antimicrobial activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract To evaluate the effects of a neutron activation radiolabeling technique on an enteric-coated multiparticulate formulation of erythromycin, test quantities were produced under industrial pilot scale conditions. The pellets contained the stable isotope erbium oxide (Er-170), which was later converted by neutron activation into the short-lived gamma ray-emitting radionuclide, erbium-171. In vitro studies indicated that the dissolution profile, acid resistance, and enteric-coated surface of the pellets were minimally affected by the irradiation procedure. Antimicrobial potency was also unaffected, as determined by microbiological assay. Neutron activation thus appears to simplify the radiolabeling of complex pharmaceutical dosage forms for in vivo study by external gamma scintigraphy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015826229323
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Complete Loss of the RUNX1 Gene: A Review of the Implications for Leukemogenesis and Patient Management (2008)
    American Society of Hematology
    Details
    Publication Date: 2008-11-16
    Description: The RUNX1 (AML1) gene is a transcription factor that regulates expression of genes involved in hematopoietic cell differentiation. It is a gene located on chromosome 21 at q22. Genetic alterations of RUNX1 whether through loss-of-function point mutations, translocation or amplification are known to impact myeloid differentiation and trigger leukemic transformation in particular with respect to myelodysplasia and acute myeloid leukemia. However, while there are many articles describing the impact of these types of RUNX1 genetic alterations, there is a paucity of information regarding loss of the entire RUNX1 gene. The case in this abstract highlights the significance of understanding loss of the RUNX1 gene. An 87 year old patient presented for evaluation for anemia and leukopenia. Flow cytometric evaluation revealed 26% myeloid blasts and confirmed a diagnosis of acute myeloid leukemia (AML). The cytogenetic findings demonstrated a translocation between chromosomes 17 and 21 −t(17;21)(q11.2;q22). The dilemma then was to determine if this was a variant of the traditional t(15;17) associated with acute promyelocytic leukemia or a variant of the t(8;21) associated with the M2 subtype of AML. FISH studies determined that there was no involvement of the RARA gene and no evidence of a RUNX1/ETO rearrangement. However, there was a complete loss of RUNX1 on the abnormal chromosome 21. Thus, what appeared to be a balanced translocation included a cryptic loss of RUNX1. While this may be an interesting case presentation the more pertinent question is what is the impact of the RUNX1 loss? This case prompted a review of the data on complete loss of the RUNX1 gene which while limited suggests that RUNX1 loss on its own is not leukemogenic. This poster presents the data and implication of complete loss of RUNX1, the role of this loss in leukemogenesis and patient management.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 4
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    Thrombocytopenia Associated with Increase in Disease Severity and Mortality in COVID-19 Patients (2020)
    American Society of Hematology
    Details
    Publication Date: 2020-11-05
    Description: Introduction:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing novel COVID-19 is spreading all across the globe like wildfire. As was the case with severe acute respiratory syndrome coronavirus (SARS) in 2002 and Middle East respiratory syndrome (MERS) in 2012, several hematological laboratory abnormalities have been identified. Several studies have reported prevalence and mechanism behind COVID-19 patients presenting with thrombocytopenia, however its association with disease severity and mortality is poorly understood. In this study we seek to investigate these clinical outcomes. Methods:Retrospective data on 7597 consecutive hospitalized patients with COVID-19 was recorded. Data included demographical information, comorbidities, admission laboratory markers, nadir platelet count and time to platelet nadir. Platelet count was categorized as grade 1 (150K-75,001), grade 2 (75K-50,001), grade 3 (50K-25,001), grade 4 (25K-10,001), and grade 5 (
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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    PAPER CURRENT
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