Publikationsdatum:
2015-12-11
Beschreibung:
We propose porous silicon nanoparticles (PSi NPs) with natural oxide coating as biocompatible and bioresorbable contrast agents for magnetic resonant imaging (MRI). A strong shortening of the transversal proton relaxation time (T 2 ) was observed for aqueous suspensions of PSi NPs, whereas the longitudinal relaxation time (T 1 ) changed moderately. The longitudinal and transversal relaxivities are estimated to be 0.03 and 0.4 l/(g·s), respectively, which are promising for biomedical studies. The proton relaxation is suggested to undergo via the magnetic dipole-dipole interaction with Si dangling bonds on surfaces of PSi NPs. MRI experiments with phantoms have revealed the remarkable contrasting properties of PSi NPs for medical diagnostics.
Print ISSN:
0003-6951
Digitale ISSN:
1077-3118
Thema:
Physik
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