Electronic Resource
[S.l.]
:
American Institute of Physics (AIP)
Physics of Fluids
8 (1996), S. 1720-1731
ISSN:
1089-7666
Source:
AIP Digital Archive
Topics:
Physics
Notes:
Results are presented for the effect of solute–fiber hydrodynamic interactions on the hindered diffusion of a spherical macromolecule in random media comprised of cylindrical fibers. Hydrodynamic interactions are calculated by representing the sphere as a collection of point singularities and accounting for the fibers by using a numerical version of slender-body theory. Electrostatic and other nonhydrodynamic interactions are neglected. The calculations show that the hydrodynamic mobility of the solute decreases in an exponential-like fashion as the fiber volume fraction is increased. Also, at a given volume fraction, a medium of thinner fibers hinders solute transport more than a medium of thicker fibers. The results compare well with experimental data, both for protein diffusion in solutions of the polysaccharide Dextran and for protein diffusion in cross-linked agarose gels. © 1996 American Institute of Physics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1063/1.868884
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