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  • Springer  (160)
  • American Institute of Physics (AIP)
  • American Meteorological Society (AMS)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Immunogenetics 6 (1978), S. 269-276 
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Immunofluorescence tests indicate that alloantibodies specific for mouse histocompatibility antigens H-1a, H-3a, and H-13a have been produced, using four different immunizations. Furthermore, an immunization employing donors and recipients which were H-2k at the MHC produced stronger anti-H-3a and anti-H-13a than did immunizations where donors and recipients were H-2b at the MHC.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Immunogenetics 4 (1977), S. 257-266 
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Alloantibodies specific for non-H-2 histocompatibility antigens of the mouse have been produced. Immunization (BALB/cJ×DBA/2J)F1 anti-B10.D2/n was conducted, followed by hemagglutination, immunofluorescence, and mixed hemabsorption tests on absorbed and unabsorbed sera. The results indicate that antibodies specific for H-3a and H-8a antigens are present. In addition, H-8a antigenic determinants were detected on erythrocyte membrane surfaces, as well as on cells of other body tissues.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract An experiment is described which compares the performance of a neural network to human performance on a visual task which consists of detecting a target in a background image of correlated noise. A three-layer, feed-forward, multi-layer perceptron is trained to indicate the presence or absence of a target in images also presented to human observers. The basis for the comparison between the network and the human observers is the receiver operating characteristic (ROC) curve. Network performance is comparable to human performance for this particular task.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Biological cybernetics 59 (1988), S. 257-263 
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract The utility of the back-propagation method in establishing suitable weights in a distributed adaptive network has been demonstrated repeatedly. Unfortunately, in many applications, the number of iterations required before convergence can be large. Modifications to the back-propagation algorithm described by Rumelhart et al. (1986) can greatly accelerate convergence. The modifications consist of three changes:1) instead of updating the network weights after each pattern is presented to the network, the network is updated only after the entire repertoire of patterns to be learned has been presented to the network, at which time the algebraic sums of all the weight changes are applied:2) instead of keeping η, the “learning rate” (i.e., the multiplier on the step size) constant, it is varied dynamically so that the algorithm utilizes a near-optimum η, as determined by the local optimization topography; and3) the momentum factor α is set to zero when, as signified by a failure of a step to reduce the total error, the information inherent in prior steps is more likely to be misleading than beneficial. Only after the network takes a useful step, i.e., one that reduces the total error, does α again assume a non-zero value. Considering the selection of weights in neural nets as a problem in classical nonlinear optimization theory, the rationale for algorithms seeking only those weights that produce the globally minimum error is reviewed and rejected.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular modeling 3 (1997), S. 338-346 
    ISSN: 0948-5023
    Keywords: Keywords: Free-Wilson-analysis ; PLS ; genetic algorithm ; CoMFA ; piritrexim analogous
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Quantitative structure-activity relationships for piritrexim and analogues acting as inhibitors of tumour cell growth have been derived. First the Free-Wilson-method was used on a homologous training set of eight derivatives. The selection of variables important for the biological activity of the compounds was carried out with different multivariate methods as multiple linear regression, the partial least squares method und a genetic algorithm. The derivation of three-dimensional structure activity relationships started with a systematic conformational analysis of all compounds. For the conformations having minimal energy and being in agreement with the crystal structure of piritrexim charges were calculated with the AM1 hamiltonian. For the superimposition of the derivatives two methods were used: maximal similarity of the common substructure or of the molecular fields. A Comparative Molecular Field Analysis with steric and electrostastic fields identified regions important for the activity of the studied compounds independent of the chosen alignment and also correctly predicted the activity of two nonhomologous compounds.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    JETP letters 63 (1996), S. 43-49 
    ISSN: 1090-6487
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Slight changes with temperature in the director orientation at the surface of a perfect planar cholesteric liquid crystal (CLC) layer, which are precursors of a jump in the pitch of the cholesteric helix, are observed by measuring the temperature dependence of the optical transmission spectra of the layer. The observed changes in the director orientation are described in the framework of the continuum theory of CLCs, supplemented with allowance for the surface anchoring forces. In particular, the angle of deviation of the director at the surface from the alignment direction at the exact temperature of the jump in pitch is expressed in terms of the anchoring potential. The relation obtained is use to find the anchoring potential in the samples.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of experimental and theoretical physics 85 (1997), S. 285-291 
    ISSN: 1090-6509
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Hysteresis of the temperature of jumps in the cholesteric pitch in planar layers of cholesteric liquid crystals (CLCs) has been observed in the temperature dependence of the optical transmission spectra measured in a 4.8 ¼m thick specimen of a 60% chiral racemic mixture of CE6. The temperature difference for the pitch jumps during heating and cooling was equal to about 0.1°C near 40.3°C. No difference in the temperature of the pitch jumps during heating and cooling was observed for an 18 µm thick specimen. A theoretical description of this hysteresis is presented on the basis of a continuum theory of elasticity of CLCs that also takes account of the surface anchoring of the CLC. Different possible mechanisms leading to a change in the director configuration in the layer during a pitch jump and their correspondence to the jump mechanism and hysteresis which occur in the experimental specimens are discussed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 94 (1991), S. 2509-2512 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The frequency of seven rovibrational transitions in the ν3 band, Q branch of 188OsO4 have been measured with high accuracy. The spectrometer used consists of two CO2 lasers [∼3 W on the 10R(0)], the first of which is stabilized on the 4.3 μm fluorescence Lamb dip of the CO2 and the second on the saturated absorption dip of the rovibrational transitions of 188OsO4. The OsO4 transition frequencies are obtained combining the known frequency of the first laser with the measured frequency of the beat note between the two laser beams. For the assignment of the transitions the recent Fourier transform analysis by Bobin et al. [J. Mol. Spectrosc. 122, 229 (1987)] was used. The access to the 10R(0) laser line has made it possible to investigate, for the first time, the Q branch of the ν3 band of OsO4 in a sub-Doppler regime. Furthermore, the tetrahedral fine structure in the ground and in the ν3 state has been analyzed using the infrared–radio frequency double resonance technique. The tetrahedral splitting constants, Dt for the ground state and Z3t for the ν3 state, have been calculated with higher accuracy than in previous works.
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  • 9
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 109 (1998), S. 9744-9752 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Thirteen new rotational transitions of H2O+ in the (0,0,0) level of the X˜ 2B1 state have been measured in the wavenumber region between 80 and 200 cm−1 (50 and 120 μm) by far-infrared laser magnetic resonance (LMR) spectroscopy. LMR data measured previously between 25 and 90 cm−1 (110 and 400 μm), as well as optical and infrared combination differences, have been combined with the new LMR data in a weighted least-squares analysis using an A-reduced expression of the rotational-fine structure Hamiltonian. Thirty-two molecular constants were simultaneously determined, some sextic centrifugal distortion parameters and some quartic and sextic spin-rotation parameters for the first time. From this improved set of molecular parameters, very accurate calculations of rotational term values and zero-field predictions of the 111–000 transition, including hyperfine structure, have been performed. Moreover, the electronic g-tensors and the hyperfine coupling constants are consistent with ab initio calculations which had been carried out for these constants. © 1998 American Institute of Physics.
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 8697-8705 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Atomic-force pictures reveal a heterogeneous microstructure at the surface of glassy layers which should be similar to one of the many equivalent microstructures a liquid is running through. These microstructures are described with the aid of a kinetic model of reversible aggregation which goes back to formulations as used in the description of living polymerization or aggregation of polymers in solution. Aggregates are considered as dynamic subsystems wherein collective modes of motions are excited. Fluctuations of the aggregates, densely packed in a disordered pattern, leads to a broad size distribution which happens to be controlled by Boltzmann's factor. The disordered structure within the aggregates themselves is optimized, reduced aggregate energy and entropy should be equal. Symmetries are deduced which elucidate many universal properties of the dynamic microstructure of liquids. Thermodynamic properties like the specific heats of aggregation in liquids or the dependence of the glass transition of homologues of linear atactic polystyrene are consistently described. © 1997 American Institute of Physics.
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