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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2019
    Description: 〈p〉Inspired by the dynamics of the dissipative self-assembly of microtubules, chemically fueled synthetic systems with transient lifetimes are emerging for nonequilibrium materials design. However, realizing programmable or even adaptive structural dynamics has proven challenging because it requires synchronization of energy uptake and dissipation events within true steady states, which remains difficult to orthogonally control in supramolecular systems. Here, we demonstrate full synchronization of both events by ATP-fueled activation and dynamization of covalent DNA bonds via an enzymatic reaction network of concurrent ligation and cleavage. Critically, the average bond ratio and the frequency of bond exchange are imprinted into the energy dissipation kinetics of the network and tunable through its constituents. We introduce temporally and structurally programmable dynamics by polymerization of transient, dynamic covalent DNA polymers with adaptive steady-state properties in dependence of ATP fuel and enzyme concentrations. This approach enables generic access to nonequilibrium soft matter systems with adaptive and programmable dynamics.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
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  • 2
    Publication Date: 2001-05-08
    Description: Atoms interacting with intense laser fields can emit electrons and photons of very high energies. An intuitive and quantitative explanation of these highly nonlinear processes can be found in terms of a generalization of classical Newtonian particle trajectories, the so-called quantum orbits. Very few quantum orbits are necessary to reproduce the experimental results. These orbits are clearly identified, thus opening the way for an efficient control as well as previously unknown applications of these processes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salieres, P -- Carre, B -- Le Deroff, L -- Grasbon, F -- Paulus, G G -- Walther, H -- Kopold, R -- Becker, W -- Milosevic, D B -- Sanpera, A -- Lewenstein, M -- New York, N.Y. -- Science. 2001 May 4;292(5518):902-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre d'Etudes de Saclay, CEA/DRECAM/SPAM, 91191 Gif-sur-Yvette, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11340197" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2002-02-16
    Description: Synchrotron x-radiography and a fast x-ray detector were used to record the time evolution of the transient fuel sprays from a high-pressure injector. A succession of 5.1-microsecond radiographs captured the propagation of the spray-induced shock waves in a gaseous medium and revealed the complex nature of the spray hydrodynamics. The monochromatic x-radiographs also allow quantitative analysis of the shock waves that has been difficult if not impossible with optical imaging. Under injection conditions similar to those found in operating engines, the fuel jets can exceed supersonic speeds and result in gaseous shock waves.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉MacPhee, Andrew G -- Tate, Mark W -- Powell, Christopher F -- Yue, Yong -- Renzi, Matthew J -- Ercan, Alper -- Narayanan, Suresh -- Fontes, Ernest -- Walther, Jochen -- Schaller, Johannes -- Gruner, Sol M -- Wang, Jin -- DMR-9713424/PHS HHS/ -- New York, N.Y. -- Science. 2002 Feb 15;295(5558):1261-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Advanced Photon Source and, Energy System Division, Argonne National Laboratory, Argonne, IL 60439, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11847333" target="_blank"〉PubMed〈/a〉
    Keywords: Cerium ; *Gasoline ; *Pressure ; Rheology ; Sulfur Hexafluoride ; *Synchrotrons ; Temperature ; *X-Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2006-04-08
    Description: The liver can regenerate its volume after major tissue loss. In a mouse model of liver regeneration, thrombocytopenia, or impaired platelet activity resulted in the failure to initiate cellular proliferation in the liver. Platelets are major carriers of serotonin in the blood. In thrombocytopenic mice, a serotonin agonist reconstituted liver proliferation. The expression of 5-HT2A and 2B subtype serotonin receptors in the liver increased after hepatectomy. Antagonists of 5-HT2A and 2B receptors inhibited liver regeneration. Liver regeneration was also blunted in mice lacking tryptophan hydroxylase 1, which is the rate-limiting enzyme for the synthesis of peripheral serotonin. This failure of regeneration was rescued by reloading serotonin-free platelets with a serotonin precursor molecule. These results suggest that platelet-derived serotonin is involved in the initiation of liver regeneration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lesurtel, Mickael -- Graf, Rolf -- Aleil, Boris -- Walther, Diego J -- Tian, Yinghua -- Jochum, Wolfram -- Gachet, Christian -- Bader, Michael -- Clavien, Pierre-Alain -- New York, N.Y. -- Science. 2006 Apr 7;312(5770):104-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Visceral and Transplantation Surgery, University Hospital of Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16601191" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Hydroxytryptophan/pharmacology ; Amphetamines/pharmacology ; Animals ; Blood Platelets/metabolism/*physiology ; Busulfan/pharmacology ; Cell Proliferation ; Hepatectomy ; Hepatocytes/cytology ; Liver/metabolism/*physiology ; *Liver Regeneration ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Platelet Count ; Receptor, Serotonin, 5-HT2A/metabolism ; Receptor, Serotonin, 5-HT2B/metabolism ; Serotonin/blood/*physiology ; Serotonin 5-HT2 Receptor Antagonists ; Thrombocytopenia ; Ticlopidine/analogs & derivatives/pharmacology ; Tryptophan Hydroxylase/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Unknown
    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-02-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walther, Gian-Reto -- New York, N.Y. -- Science. 2007 Feb 2;315(5812):606-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Ecology, University of Bayreuth, 95440 Bayreuth, Germany. gian-reto.walther@uni-bayreuth.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17272708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; California ; *Climate ; *Ecosystem ; *Invertebrates/physiology ; *Plant Development ; Poaceae/growth & development ; Population Dynamics ; Rain ; Research Design ; Seasons ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2012-01-24
    Description: Quantum computers, besides offering substantial computational speedups, are also expected to preserve the privacy of a computation. We present an experimental demonstration of blind quantum computing in which the input, computation, and output all remain unknown to the computer. We exploit the conceptual framework of measurement-based quantum computation that enables a client to delegate a computation to a quantum server. Various blind delegated computations, including one- and two-qubit gates and the Deutsch and Grover quantum algorithms, are demonstrated. The client only needs to be able to prepare and transmit individual photonic qubits. Our demonstration is crucial for unconditionally secure quantum cloud computing and might become a key ingredient for real-life applications, especially when considering the challenges of making powerful quantum computers widely available.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barz, Stefanie -- Kashefi, Elham -- Broadbent, Anne -- Fitzsimons, Joseph F -- Zeilinger, Anton -- Walther, Philip -- New York, N.Y. -- Science. 2012 Jan 20;335(6066):303-8. doi: 10.1126/science.1214707.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vienna Center for Quantum Science and Technology, Faculty of Physics, University of Vienna, Boltzmanngasse 5, A-1090 Vienna, Austria. stefanie.barz@univie.ac.at〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22267806" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2003-06-21
    Description: We demonstrate the distribution of quantum entanglement via optical free-space links to independent receivers separated by 600 m, with no line of sight between each other. A Bell inequality between those receivers is violated by more than four standard deviations, confirming the quality of the entanglement. This outdoor experiment represents a step toward satellite-based distributed quantum entanglement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aspelmeyer, Markus -- Bohm, Hannes R -- Gyatso, Tsewang -- Jennewein, Thomas -- Kaltenbaek, Rainer -- Lindenthal, Michael -- Molina-Terriza, Gabriel -- Poppe, Andreas -- Resch, Kevin -- Taraba, Michael -- Ursin, Rupert -- Walther, Philip -- Zeilinger, Anton -- New York, N.Y. -- Science. 2003 Aug 1;301(5633):621-3. Epub 2003 Jun 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut fur Experimentalphysik, Universitat Wien, Boltzmanngasse 5, A-1090 Wien, Austria. markus.aspelmeyer@quantum.at〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12817085" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2003-01-04
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walther, Diego J -- Peter, Jens-Uwe -- Bashammakh, Saleh -- Hortnagl, Heide -- Voits, Mechthild -- Fink, Heidrun -- Bader, Michael -- New York, N.Y. -- Science. 2003 Jan 3;299(5603):76.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Max Delbruck Center for Molecular Medicine (MDC), Robert-Rossle-Strasse 10, D-13092 Berlin-Buch, Germany. dwalther@mdc-berlin.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12511643" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Brain/*enzymology/metabolism ; COS Cells ; Cloning, Molecular ; Conserved Sequence ; DNA, Complementary ; Duodenum/enzymology/metabolism ; Humans ; Hydroxylation ; Isoenzymes/chemistry/genetics/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; RNA, Messenger/genetics/metabolism ; Rats ; Serotonin/*biosynthesis ; Transfection ; Tryptophan Hydroxylase/chemistry/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2004-02-14
    Description: Cell-to-cell communication is a crucial prerequisite for the development and maintenance of multicellular organisms. To date, diverse mechanisms of intercellular exchange of information have been documented, including chemical synapses, gap junctions, and plasmodesmata. Here, we describe highly sensitive nanotubular structures formed de novo between cells that create complex networks. These structures facilitate the selective transfer of membrane vesicles and organelles but seem to impede the flow of small molecules. Accordingly, we propose a novel biological principle of cell-to-cell interaction based on membrane continuity and intercellular transfer of organelles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rustom, Amin -- Saffrich, Rainer -- Markovic, Ivanka -- Walther, Paul -- Gerdes, Hans-Hermann -- New York, N.Y. -- Science. 2004 Feb 13;303(5660):1007-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Interdisciplinary Center of Neuroscience (IZN), Institute of Neurobiology, University of Heidelberg, INF 364, Heidelberg 69120, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14963329" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; Animals ; Biological Transport ; Carbocyanines/metabolism ; *Cell Communication ; Cell Line ; Cell Membrane/metabolism ; Cell Surface Extensions/*metabolism/*ultrastructure ; Endocytosis ; Endosomes/metabolism ; Fluorescent Dyes/metabolism ; Green Fluorescent Proteins ; Luminescent Proteins/metabolism ; Membrane Proteins/metabolism ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Microscopy, Video ; Organelles/*metabolism ; PC12 Cells ; Protein Prenylation ; Protein Transport ; Pseudopodia/metabolism/ultrastructure ; Rats ; Recombinant Fusion Proteins/metabolism ; Synaptophysin/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2005-01-18
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Balmford, Andrew -- Bennun, Leon -- Brink, Ben Ten -- Cooper, David -- Cote, Isabelle M -- Crane, Peter -- Dobson, Andrew -- Dudley, Nigel -- Dutton, Ian -- Green, Rhys E -- Gregory, Richard D -- Harrison, Jeremy -- Kennedy, Elizabeth T -- Kremen, Claire -- Leader-Williams, Nigel -- Lovejoy, Thomas E -- Mace, Georgina -- May, Robert -- Mayaux, Phillipe -- Morling, Paul -- Phillips, Joanna -- Redford, Kent -- Ricketts, Taylor H -- Rodriguez, Jon Paul -- Sanjayan, M -- Schei, Peter J -- van Jaarsveld, Albert S -- Walther, Bruno A -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):212-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cambridge University and University of Cape Town.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15653489" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; *Conservation of Natural Resources ; *Ecology ; Ecosystem ; Humans ; Interdisciplinary Communication ; International Cooperation ; Models, Biological ; Models, Theoretical ; Public Policy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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