Publication Date:
2002-03-02
Description:
The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Velcich, Anna -- Yang, WanCai -- Heyer, Joerg -- Fragale, Alessandra -- Nicholas, Courtney -- Viani, Stephanie -- Kucherlapati, Raju -- Lipkin, Martin -- Yang, Kan -- Augenlicht, Leonard -- CA 72835/CA/NCI NIH HHS/ -- CA 90808/CA/NCI NIH HHS/ -- P0 CA 13330/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 1;295(5560):1726-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncology, Albert Einstein Cancer Center/Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA. velcich@aecom.yu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11872843" target="_blank"〉PubMed〈/a〉
Keywords:
Adenocarcinoma/chemistry/pathology
;
Adenoma/chemistry/pathology
;
Animals
;
Apoptosis
;
Cell Differentiation
;
Cell Division
;
Cell Lineage
;
Cell Movement
;
Colon/chemistry/cytology/pathology
;
Colorectal Neoplasms/*etiology/metabolism/pathology
;
Cytoskeletal Proteins/analysis
;
Disease Progression
;
Duodenal Neoplasms/chemistry/pathology
;
Duodenum/chemistry/cytology/pathology
;
Epithelial Cells/chemistry/physiology
;
Female
;
Gene Targeting
;
Goblet Cells/cytology
;
Intestinal Mucosa/chemistry/cytology/pathology
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Mutant Strains
;
Mucin-2
;
Mucins/analysis/*genetics/*physiology
;
Proto-Oncogene Proteins c-myc/analysis
;
*Trans-Activators
;
beta Catenin
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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