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  • 1
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    Friction anisotropy and asymmetry of a compliant monolayer induced by a small molecular tilt (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-04-29
    Description: Lateral force microscopy in the wearless regime was used to study the friction behavior of a lipid monolayer on mica. In the monolayer, condensed domains with long-range orientational order of the lipid molecules were present. The domains revealed unexpectedly strong friction anisotropies and non-negligible friction asymmetries. The angular dependency of these effects correlated well with the tilt direction of the alkyl chains of the monolayer, as determined by electron diffraction and Brewster angle microscopy. The molecular tilt causing these frictional effects was less than 15 degrees, demonstrating that even small molecular tilts can make a major contribution to friction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liley -- Gourdon -- Stamou -- Meseth -- Fischer -- Lautz -- Stahlberg -- Vogel -- Burnham -- Duschl -- New York, N.Y. -- Science. 1998 Apr 10;280(5361):273-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉M. Liley, D. Stamou, U. Meseth, H. Vogel, C. Duschl, Department of Chemistry, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland. D. Gourdon and N. A. Burnham, Department of Physics, Swiss Federal Institute of Technology, CH-1015.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9535654" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Axonal neuregulin-1 regulates myelin sheath thickness (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-27
    Description: In the nervous system of vertebrates, myelination is essential for rapid and accurate impulse conduction. Myelin thickness depends on axon fiber size. We use mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells. Reduced Nrg1 expression causes hypomyelination and reduced nerve conduction velocity. Neuronal overexpression of Nrg1 induces hypermyelination and demonstrates that Nrg1 type III is the responsible isoform. We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michailov, Galin V -- Sereda, Michael W -- Brinkmann, Bastian G -- Fischer, Tobias M -- Haug, Bernhard -- Birchmeier, Carmen -- Role, Lorna -- Lai, Cary -- Schwab, Markus H -- Nave, Klaus-Armin -- New York, N.Y. -- Science. 2004 Apr 30;304(5671):700-3. Epub 2004 Mar 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15044753" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*physiology/*ultrastructure ; Ganglia, Spinal/chemistry ; Gene Targeting ; Genes, erbB ; Genes, erbB-2 ; Heterozygote ; Mice ; Mice, Knockout ; Mice, Transgenic ; Models, Neurological ; Myelin Sheath/*physiology/*ultrastructure ; Neural Conduction ; Neuregulin-1/genetics/*physiology ; Protein Isoforms/physiology ; Receptor, Epidermal Growth Factor/analysis/physiology ; Receptor, ErbB-2/analysis/physiology ; Receptor, ErbB-3/analysis/physiology ; Schwann Cells/physiology ; Sciatic Nerve/chemistry ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The red cell as a fluid droplet: tank tread-like motion of the human erythrocyte membrane in shear flow (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: When whole human blood is subjected to viscometric flow, individual red cells are seen to be elongated and oriented in the shear field. In addition, a tank tread-like motion of the membrane around the cell content occurs. In dilute suspensions of erythrocytes in viscous media, the same behavior is better observed and can also be measured quantitatively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fischer, T M -- Stohr-Lissen, M -- Schmid-Schonbein, H -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):894-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715448" target="_blank"〉PubMed〈/a〉
    Keywords: *Blood Viscosity ; Erythrocyte Membrane/*physiology ; Erythrocytes/*physiology/ultrastructure ; Humans ; Rheology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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