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  • 1
    Publication Date: 2013-01-26
    Description: Pulsars emit from low-frequency radio waves up to high-energy gamma-rays, generated anywhere from the stellar surface out to the edge of the magnetosphere. Detecting correlated mode changes across the electromagnetic spectrum is therefore key to understanding the physical relationship among the emission sites. Through simultaneous observations, we detected synchronous switching in the radio and x-ray emission properties of PSR B0943+10. When the pulsar is in a sustained radio-"bright" mode, the x-rays show only an unpulsed, nonthermal component. Conversely, when the pulsar is in a radio-"quiet" mode, the x-ray luminosity more than doubles and a 100% pulsed thermal component is observed along with the nonthermal component. This indicates rapid, global changes to the conditions in the magnetosphere, which challenge all proposed pulsar emission theories.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hermsen, W -- Hessels, J W T -- Kuiper, L -- van Leeuwen, J -- Mitra, D -- de Plaa, J -- Rankin, J M -- Stappers, B W -- Wright, G A E -- Basu, R -- Alexov, A -- Coenen, T -- Griessmeier, J-M -- Hassall, T E -- Karastergiou, A -- Keane, E -- Kondratiev, V I -- Kramer, M -- Kuniyoshi, M -- Noutsos, A -- Serylak, M -- Pilia, M -- Sobey, C -- Weltevrede, P -- Zagkouris, K -- Asgekar, A -- Avruch, I M -- Batejat, F -- Bell, M E -- Bell, M R -- Bentum, M J -- Bernardi, G -- Best, P -- Birzan, L -- Bonafede, A -- Breitling, F -- Broderick, J -- Bruggen, M -- Butcher, H R -- Ciardi, B -- Duscha, S -- Eisloffel, J -- Falcke, H -- Fender, R -- Ferrari, C -- Frieswijk, W -- Garrett, M A -- de Gasperin, F -- de Geus, E -- Gunst, A W -- Heald, G -- Hoeft, M -- Horneffer, A -- Iacobelli, M -- Kuper, G -- Maat, P -- Macario, G -- Markoff, S -- McKean, J P -- Mevius, M -- Miller-Jones, J C A -- Morganti, R -- Munk, H -- Orru, E -- Paas, H -- Pandey-Pommier, M -- Pandey, V N -- Pizzo, R -- Polatidis, A G -- Rawlings, S -- Reich, W -- Rottgering, H -- Scaife, A M M -- Schoenmakers, A -- Shulevski, A -- Sluman, J -- Steinmetz, M -- Tagger, M -- Tang, Y -- Tasse, C -- ter Veen, S -- Vermeulen, R -- van de Brink, R H -- van Weeren, R J -- Wijers, R A M J -- Wise, M W -- Wucknitz, O -- Yatawatta, S -- Zarka, P -- New York, N.Y. -- Science. 2013 Jan 25;339(6118):436-9. doi: 10.1126/science.1230960.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉SRON, Netherlands Institute for Space Research, Sorbonnelaan 2, 3584 CA Utrecht, Netherlands. w.hermsen@sron.nl〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23349288" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1988-06-03
    Description: In a study aimed at developing a vaccine against the asexual blood stages of Plasmodium falciparum, two T cell epitopes were identified within a nonpolymorphic region of gp190 of Plasmodium falciparum merozoites. The two epitopes, which were revealed by deletion analysis, stimulated human T cell clones. Peptides containing sequences of the epitopes stimulated the cloned T cells and peripheral blood mononuclear cells (PBMC) from malaria-infected individuals. Moreover, the T cell clones responded to 11 different Plasmodium falciparum isolates in culture, showing that the epitopes are recognized in native parasites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crisanti, A -- Muller, H M -- Hilbich, C -- Sinigaglia, F -- Matile, H -- McKay, M -- Scaife, J -- Beyreuther, K -- Bujard, H -- New York, N.Y. -- Science. 1988 Jun 3;240(4857):1324-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zentrum fur Molekulare Biologie, Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2453924" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, Protozoan/*immunology ; Epitopes/analysis/*immunology ; Humans ; Molecular Sequence Data ; Peptide Fragments/immunology ; Plasmodium falciparum/*immunology ; T-Lymphocytes/*immunology ; T-Lymphocytes, Helper-Inducer/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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