Publication Date:
2013-09-07
Description:
Bijvoet's method, which makes use of anomalous x-ray diffraction or dispersion, is the standard means of directly determining the absolute (stereochemical) configuration of molecules, but it requires crystalline samples and often proves challenging in structures exclusively comprising light atoms. Herein, we demonstrate a mass spectrometry approach that directly images the absolute configuration of individual molecules in the gas phase by cold target recoil ion momentum spectroscopy after laser ionization-induced Coulomb explosion. This technique is applied to the prototypical chiral molecule bromochlorofluoromethane and the isotopically chiral methane derivative bromodichloromethane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pitzer, Martin -- Kunitski, Maksim -- Johnson, Allan S -- Jahnke, Till -- Sann, Hendrik -- Sturm, Felix -- Schmidt, Lothar Ph H -- Schmidt-Bocking, Horst -- Dorner, Reinhard -- Stohner, Jurgen -- Kiedrowski, Julia -- Reggelin, Michael -- Marquardt, Sebastian -- Schiesser, Alexander -- Berger, Robert -- Schoffler, Markus S -- New York, N.Y. -- Science. 2013 Sep 6;341(6150):1096-100. doi: 10.1126/science.1240362.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Nuclear Physics, Johann Wolfgang Goethe-Universitat Frankfurt, Max-von-Laue-Strasse 1, 60438 Frankfurt, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24009390" target="_blank"〉PubMed〈/a〉
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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