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  • 1
    Publication Date: 2001-03-17
    Description: The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is initiated by recognition of ligand followed by oligomerization into a higher order signaling complex. Kaposi's sarcoma-associated herpesvirus encodes a functional homolog of human interleukin-6 (IL-6) that activates human gp130. In the 2.4 angstrom crystal structure of the extracellular signaling assembly between viral IL-6 and human gp130, two complexes are cross-linked into a tetramer through direct interactions between the immunoglobulin domain of gp130 and site III of viral IL-6, which is necessary for receptor activation. Unlike human IL-6 (which uses many hydrophilic residues), the viral cytokine largely uses hydrophobic amino acids to contact gp130, which enhances the complementarity of the viral IL-6-gp130 binding interfaces. The cross-reactivity of gp130 is apparently due to a chemical plasticity evident in the amphipathic gp130 cytokine-binding sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chow , D -- He , X -- Snow, A L -- Rose-John, S -- Garcia, K C -- R01-AI-48540-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Mar 16;291(5511):2150-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, Fairchild D319, 299 Campus Drive, Stanford, CA 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11251120" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, CD/*chemistry/*metabolism ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; Cytokine Receptor gp130 ; Epitopes ; Humans ; Hydrogen Bonding ; Interleukin-6/*chemistry/immunology/*metabolism ; Membrane Glycoproteins/*chemistry/*metabolism ; Models, Molecular ; Molecular Mimicry ; Protein Conformation ; Protein Structure, Quaternary ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Signal Transduction ; Viral Proteins/*chemistry/immunology/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1994-08-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rose, S -- New York, N.Y. -- Science. 1994 Aug 26;265(5176):1159.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8066453" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Genetics, Behavioral ; Humans ; *Social Problems
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2016-04-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burke, M -- Craxton, M -- Kolstad, C D -- Onda, C -- Allcott, H -- Baker, E -- Barrage, L -- Carson, R -- Gillingham, K -- Graff-Zivin, J -- Greenstone, M -- Hallegatte, S -- Hanemann, W M -- Heal, G -- Hsiang, S -- Jones, B -- Kelly, D L -- Kopp, R -- Kotchen, M -- Mendelsohn, R -- Meng, K -- Metcalf, G -- Moreno-Cruz, J -- Pindyck, R -- Rose, S -- Rudik, I -- Stock, J -- Tol, R S J -- New York, N.Y. -- Science. 2016 Apr 15;352(6283):292-3. doi: 10.1126/science.aad9634. Epub 2016 Apr 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stanford University, Stanford, CA, USA. ; Stanford University, Stanford, CA, USA. ckolstad@stanford.edu. ; New York University, New York, NY, USA. ; University of Massachusetts, Amherst, MA, USA. ; Brown University, Providence, RI, USA. ; University of California, San Diego, CA, USA. ; Yale University, New Haven, CT, USA. ; University of Chicago, Chicago, IL, USA. ; World Bank, Washington, DC, USA. ; Arizona State University, Tempe, AZ, USA. ; Columbia University, New York, NY, USA. ; University of California, Berkeley, CA, USA. ; Northwestern University, Evanston, IL, USA. ; University of Miami, Coral Gables, FL, USA. ; Resources for the Future, Washington, DC, USA. ; University of California, Santa Barbara, CA, USA. ; Tufts University, Medford, MA, USA. ; Georgia Institute of Technology, Atlanta, GA, USA. ; Massachusetts Institute of Technology, Cambridge, MA, USA. ; Electric Power Research Institute, Palo Alto, CA, USA. ; Iowa State University, Ames, IA, USA. ; Harvard University, Cambridge, MA, USA. ; University of Sussex, Falmer, UK, and Vrije Universiteit Amsterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27081055" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2017-09-15
    Description: Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives.
    Keywords: Materials Science
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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