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  • 1
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    Atom optics. Continuous progress on atom lasers (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-22
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pfau, Tilman -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2155-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Physics, University of Stuttgart, 70550 Stuttgart, Germany. t.pfau@physik.uni-stuttgart.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077392" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Aneuploidy drives genomic instability in yeast (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-08-20
    Description: Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278960/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3278960/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sheltzer, Jason M -- Blank, Heidi M -- Pfau, Sarah J -- Tange, Yoshie -- George, Benson M -- Humpton, Timothy J -- Brito, Ilana L -- Hiraoka, Yasushi -- Niwa, Osami -- Amon, Angelika -- GM056800/GM/NIGMS NIH HHS/ -- R01 GM056800/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2011 Aug 19;333(6045):1026-30. doi: 10.1126/science.1206412.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉David H. Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute (HHMI), Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21852501" target="_blank"〉PubMed〈/a〉
    Keywords: *Aneuploidy ; Chromosome Segregation ; Chromosomes, Fungal/genetics ; *DNA Damage ; *DNA Repair ; DNA Replication ; DNA, Fungal/genetics/metabolism ; *Genome, Fungal ; *Genomic Instability ; Mutagenesis ; Mutation ; Neoplasms/genetics ; Phenotype ; Rad52 DNA Repair and Recombination Protein/genetics ; *Recombination, Genetic ; Saccharomyces cerevisiae/*genetics ; Saccharomyces cerevisiae Proteins/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    A room-temperature single-photon source based on strongly interacting Rydberg atoms (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018
    Description: 〈p〉Tailored quantum states of light can be created via a transfer of collective quantum states of matter to light modes. Such collective quantum states emerge in interacting many-body systems if thermal fluctuations are overcome by sufficient interaction strengths. Therefore, ultracold temperatures or strong confinement are typically required. We show that the exaggerated interactions between Rydberg atoms allow for collective quantum states even above room temperature. The emerging Rydberg interactions lead both to suppression of multiple Rydberg state excitations and destructive interference due to polariton dephasing. We experimentally implemented a four-wave mixing scheme to demonstrate an on-demand single-photon source. The combination of glass cell technology, identical atoms, and operation around room temperature promises scalability and integrability. This approach has the potential for various applications in quantum information processing and communication.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    A room-temperature single-photon source based on strongly interacting Rydberg atoms (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-10-26
    Description: Tailored quantum states of light can be created via a transfer of collective quantum states of matter to light modes. Such collective quantum states emerge in interacting many-body systems if thermal fluctuations are overcome by sufficient interaction strengths. Therefore, ultracold temperatures or strong confinement are typically required. We show that the exaggerated interactions between Rydberg atoms allow for collective quantum states even above room temperature. The emerging Rydberg interactions lead both to suppression of multiple Rydberg state excitations and destructive interference due to polariton dephasing. We experimentally implemented a four-wave mixing scheme to demonstrate an on-demand single-photon source. The combination of glass cell technology, identical atoms, and operation around room temperature promises scalability and integrability. This approach has the potential for various applications in quantum information processing and communication.
    Keywords: Physics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Modern riding style improves horse racing times (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-18
    Description: When animals carry loads, there is a proportionate increase in metabolic cost, and in humans this increase in cost is reduced when the load is elastically coupled to the load bearer. Major horse race times and records improved by 5 to 7% around 1900 when jockeys adopted a crouched posture. We show that jockeys move to isolate themselves from the movement of their mount. This would be difficult or impossible with a seated or upright, straight-legged posture. This isolation means that the horse supports the jockey's body weight but does not have to move the jockey through each cyclical stride path. This posture requires substantial work by jockeys, who have near-maximum heart rates during racing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pfau, Thilo -- Spence, Andrew -- Starke, Sandra -- Ferrari, Marta -- Wilson, Alan -- Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2009 Jul 17;325(5938):289. doi: 10.1126/science.1174605.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Structure and Motion Laboratory, Royal Veterinary College, University of London, Hatfield, AL9 7TA UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19608909" target="_blank"〉PubMed〈/a〉
    Keywords: Acceleration ; Animals ; Biomechanical Phenomena ; Body Weight ; Energy Metabolism ; Horses/*physiology ; Humans ; *Locomotion ; *Movement ; Physical Conditioning, Animal ; *Posture ; Sports/*physiology ; Weight-Bearing
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    A homonuclear molecule with a permanent electric dipole moment (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-11-26
    Description: Permanent electric dipole moments in molecules require a breaking of parity symmetry. Conventionally, this symmetry breaking relies on the presence of heteronuclear constituents. We report the observation of a permanent electric dipole moment in a homonuclear molecule in which the binding is based on asymmetric electronic excitation between the atoms. These exotic molecules consist of a ground-state rubidium (Rb) atom bound inside a second Rb atom electronically excited to a high-lying Rydberg state. Detailed calculations predict appreciable dipole moments on the order of 1 Debye, in excellent agreement with the observations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, W -- Pohl, T -- Rost, J M -- Rittenhouse, Seth T -- Sadeghpour, H R -- Nipper, J -- Butscher, B -- Balewski, J B -- Bendkowsky, V -- Low, R -- Pfau, T -- New York, N.Y. -- Science. 2011 Nov 25;334(6059):1110-4. doi: 10.1126/science.1211255.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Physics and Astronomy, University of Nottingham, Nottingham, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22116881" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Quantum liquids get thin (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-01-19
    Keywords: Physics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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