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  • 1
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    Foods of the future (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-06-05
    Description: We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373-alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tortorella, M D -- Burn, T C -- Pratta, M A -- Abbaszade, I -- Hollis, J M -- Liu, R -- Rosenfeld, S A -- Copeland, R A -- Decicco, C P -- Wynn, R -- Rockwell, A -- Yang, F -- Duke, J L -- Solomon, K -- George, H -- Bruckner, R -- Nagase, H -- Itoh, Y -- Ellis, D M -- Ross, H -- Wiswall, B H -- Murphy, K -- Hillman, M C Jr -- Hollis, G F -- Newton, R C -- Magolda, R L -- Trzaskos, J M -- Arner, E C -- New York, N.Y. -- Science. 1999 Jun 4;284(5420):1664-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Inflammatory Diseases Research, DuPont Pharmaceuticals Company, Wilmington, DE 19880-0400, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10356395" target="_blank"〉PubMed〈/a〉
    Keywords: ADAM Proteins ; Aggrecans ; Amino Acid Sequence ; Arthritis/drug therapy ; Cartilage/metabolism ; Catalytic Domain ; Cloning, Molecular ; Disintegrins/chemistry/metabolism ; *Extracellular Matrix Proteins ; Humans ; Hydroxamic Acids/pharmacology ; Interleukin-1/pharmacology ; Lectins, C-Type ; Metalloendopeptidases/*chemistry/*genetics/isolation & purification/metabolism ; Molecular Sequence Data ; Procollagen N-Endopeptidase ; Protease Inhibitors/pharmacology ; Protein Sorting Signals ; Proteoglycans/metabolism ; Recombinant Proteins/chemistry/metabolism ; Sequence Analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Regional 14CO2 offsets in the troposphere: magnitude, mechanisms, and consequences (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-18
    Description: Radiocarbon dating methods typically assume that there are no significant tropospheric (14)CO(2) gradients within the low- to mid-latitude zone of the Northern Hemisphere. Comparison of tree ring (14)C data from southern Germany and Anatolia supports this assumption in general but also documents episodes of significant short-term regional (14)CO(2) offsets. We suggest that the offset is caused by an enhanced seasonal (14)CO(2) cycle, with seasonally peaked flux of stratospheric (14)C into the troposphere during periods of low solar magnetic activity, coinciding with substantial atmospheric cooling. Short-term episodes of regional (14)CO(2) offsets are important to palaeoclimate studies and to high-resolution archaeological dating.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kromer, B -- Manning, S W -- Kuniholm, P I -- Newton, M W -- Spurk, M -- Levin, I -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2529-32. Epub 2001 Dec 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Heidelberger Akademie der Wissenschaften, Institut fur Umweltphysik der Universitat Heidelberg, Im Neuenheimer Feld 229, D-69120 Heidelberg, Germany. bernd.kromer@iup.uni-heidelberg.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11743160" target="_blank"〉PubMed〈/a〉
    Keywords: *Archaeology ; *Atmosphere ; Calibration ; *Carbon Dioxide ; *Carbon Radioisotopes ; Climate ; Germany ; Mediterranean Region ; Oceans and Seas ; Seasons ; Time ; *Trees/growth & development ; Turkey ; Wood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Rapid electron tunneling through oligophenylenevinylene bridges (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-27
    Description: We measured rate constants of thermal, interfacial electron transfer through oligophenylenevinylene bridges between a gold electrode and a tethered redox species in contact with an aqueous electrolyte using the indirect laser-induced temperature jump technique. Analysis of the distance dependence indicates that, unlike other bridges studied to date, the rate constants are not limited by electronic coupling for bridges up to 28 angstroms long. The energy levels of the bridges relative to those of the redox species rule out hopping through the bridge. We conclude that, out to 28 angstroms, the transfer is limited by structural reorganization and that electron tunneling occurs in less than 20 picoseconds, suggesting that oligophenylenevinylene bridges could be useful for wiring molecular electronic elements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sikes, H D -- Smalley, J F -- Dudek, S P -- Cook, A R -- Newton, M D -- Chidsey, C E -- Feldberg, S W -- 5 T32 GM08412/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Feb 23;291(5508):1519-23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA., Brookhaven National Laboratory, Upton, NY 11973, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11222852" target="_blank"〉PubMed〈/a〉
    Keywords: Electrochemistry ; Electrodes ; Electrolytes ; Electronics ; *Electrons ; Ferrous Compounds/*chemistry ; Gold ; Oxidation-Reduction ; Stilbenes/*chemistry ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Anatolian tree rings and a new chronology for the east Mediterranean Bronze-Iron Ages (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-18
    Description: We report an extensive program of high-precision radiocarbon dating to establish the best date for a floating 1599-year Anatolian tree ring chronology that spans the later third millennium B.C. through the earlier first millennium B.C. This chronology is directly associated with a number of key sites and ancient personages. A previously suggested dating is withdrawn and is replaced by a robust new date fix 22 (+4 or -7) years earlier. These new radiocarbon wiggle-matched dates offer a unique independent resource for establishing the precise chronology of the ancient Near East and Aegean and help resolve, among others, a long-standing debate in favor of the so-called Middle Mesopotamian chronology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Manning, S W -- Kromer, B -- Kuniholm, P I -- Newton, M W -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2532-5. Epub 2001 Dec 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Archaeology, University of Reading, Post Office Box 218 Whiteknights, Reading RG6 6AA, UK. S.W.Manning@reading.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11743159" target="_blank"〉PubMed〈/a〉
    Keywords: *Archaeology ; Atmosphere ; Bayes Theorem ; Carbon Dioxide ; *Carbon Radioisotopes ; Germany ; Ireland ; Least-Squares Analysis ; Pinus/growth & development ; Quercus/growth & development ; Seasons ; Software ; Time ; *Trees/growth & development ; Turkey ; Wood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-04
    Description: Many proteins associated with the plasma membrane are known to partition into submicroscopic sphingolipid- and cholesterol-rich domains called lipid rafts, but the determinants dictating this segregation of proteins in the membrane are poorly understood. We suppressed the tendency of Aequorea fluorescent proteins to dimerize and targeted these variants to the plasma membrane using several different types of lipid anchors. Fluorescence resonance energy transfer measurements in living cells revealed that acyl but not prenyl modifications promote clustering in lipid rafts. Thus the nature of the lipid anchor on a protein is sufficient to determine submicroscopic localization within the plasma membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zacharias, David A -- Violin, Jonathan D -- Newton, Alexandra C -- Tsien, Roger Y -- 2T32 GM07752/GM/NIGMS NIH HHS/ -- DK54441/DK/NIDDK NIH HHS/ -- NS27177/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2002 May 3;296(5569):913-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Biomedical Sciences Graduate Program, and, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093-0647, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11988576" target="_blank"〉PubMed〈/a〉
    Keywords: Acylation ; Animals ; Bacterial Proteins/chemistry/*metabolism ; Caveolin 1 ; Caveolins/metabolism ; Cell Line ; Detergents ; Dimerization ; Dogs ; Energy Transfer ; Fluorescence ; Green Fluorescent Proteins ; Luminescent Proteins/chemistry/*metabolism ; Membrane Microdomains/*metabolism ; Myristic Acid/metabolism ; Oligopeptides/chemistry/*metabolism ; Palmitic Acid/metabolism ; Protein Prenylation ; Recombinant Fusion Proteins/metabolism ; Solubility ; Spectrometry, Fluorescence ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    In reply: paleobiogeography of the ancient pacific (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newton, C R -- New York, N.Y. -- Science. 1990 Aug 10;249(4969):681-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17831960" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Immune response to cholera toxin epitope inserted in Salmonella flagellin (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-04-07
    Description: Bacterial flagella are potent immunogens and aromatic-dependent (aro) Salmonella as live vaccines evoke humoral and cellular immune responses. Such strains expressing epitopes of protective antigens as inserts in flagellin would provide a novel way to vaccinate against diseases caused by unrelated pathogens. A synthetic oligonucleotide specifying an epitope of cholera toxin subunit B was inserted in a Salmonella flagellin gene. The chimeric flagellin functioned normally and the epitope was expressed at the flagellar surface. Parenteral administration to mice of an aro A flagellin-negative strain of S. dublin expressing the chimeric flagellin gene evoked antibody to cholera toxin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newton, S M -- Jacob, C O -- Stocker, B A -- New York, N.Y. -- Science. 1989 Apr 7;244(4900):70-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2468182" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Bacterial/*biosynthesis ; Bacterial Proteins/*immunology ; Cholera Toxin/*immunology ; Epitopes/*immunology ; Flagellin/genetics/*immunology ; Genetic Vectors ; Mice ; Mice, Inbred C57BL ; Oligonucleotide Probes ; *Plasmids ; Salmonella/genetics/*immunology ; Vaccines, Synthetic/administration & dosage/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Shocked quartz at the triassic-jurassic boundary in Italy (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-01-24
    Description: Quartz grains that appear to have been shock-metamorphosed occur within three closely spaced shale beds from the uppermost Triassic ("Rhaetian") Calcare a Rhaetavicula in the Northern Apennines of Italy. The upper shale coincides with the abrupt termination of the distinctive, uppermost Triassic Rhaetavicula fauna and is overlain by the Hettangian (Lower Jurassic) Calcare Massiccio; no extinctions appear to be associated with the two lower layers, which occur 1.2 and 2.4 meters below the boundary shale. Approximately 5 to 10% of the quartz grains within these layers exhibit one or more sets of planar deformational features whose orientations cluster around the rational crystallographic planes (basal, omega, and pi) most commonly observed in shocked quartz. Textural and stratigraphic observations support an interpretation of at least three closely spaced impacts at the end of the Triassic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bice, D M -- Newton, C R -- McCauley, S -- Reiners, P W -- McRoberts, C A -- New York, N.Y. -- Science. 1992 Jan 24;255(5043):443-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17842896" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Comment on "Post-wildfire logging hinders regeneration and increases fire risk" (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-08-05
    Description: Donato et al. (Brevia, 20 January 2006, p. 352) concluded that logging after wildfire kills natural regeneration and increases fire risk. We argue that their paper lacks adequate context and supporting information to be clearly interpreted by scientists, resource managers, policy-makers, and the public.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newton, M -- Fitzgerald, S -- Rose, R R -- Adams, P W -- Tesch, S D -- Sessions, J -- Atzet, T -- Powers, R F -- Skinner, C -- New York, N.Y. -- Science. 2006 Aug 4;313(5787):615; author reply 615.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Forest Science, Oregon State University, Corvallis, OR 97331, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16888122" target="_blank"〉PubMed〈/a〉
    Keywords: California ; Coniferophyta/*growth & development ; *Conservation of Natural Resources ; *Fires ; *Forestry ; Oregon ; Trees/*growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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