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  • 1
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    Subducted seamount imaged in the rupture zone of the 1946 nankaido earthquake (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-07-07
    Description: The Nankai Trough is a vigorous subduction zone where large earthquakes have been recorded since the seventh century, with a recurrence time of 100 to 200 years. The 1946 Nankaido earthquake was unusual, with a rupture zone estimated from long-period geodetic data that was more than twice as large as that derived from shorter period seismic data. In the center of this earthquake rupture zone, we used densely deployed ocean bottom seismographs to detect a subducted seamount 13 kilometers thick by 50 kilometers wide at a depth of 10 kilometers. We propose that this seamount might work as a barrier inhibiting brittle seismogenic rupture.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kodaira -- Takahashi -- Nakanishi -- Miura -- Kaneda -- New York, N.Y. -- Science. 2000 Jul 7;289(5476):104-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Japan Marine Science and Technology Center, Natsushima 2-15, Yokosuka, Kanagawa 237-0061, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10884221" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-08-01
    Description: The physiological role of striatal cholinergic interneurons was investigated with immunotoxin-mediated cell targeting (IMCT). Unilateral cholinergic cell ablation caused an acute abnormal turning behavior. These mice showed gradual recovery but displayed abnormal turning by both excess stimulation and inhibition of dopamine actions. In the acute phase, basal ganglia function was shifted to a hyperactive state by stimulation and suppression of striatonigral and striatopallidal neurons, respectively. D1 and D2 dopamine receptors were then down-regulated, relieving dopamine-predominant synaptic perturbation but leaving a defect in controlling dopamine responses. The acetylcholine-dopamine interaction is concertedly and adaptively regulated for basal ganglia synaptic integration.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaneko, S -- Hikida, T -- Watanabe, D -- Ichinose, H -- Nagatsu, T -- Kreitman, R J -- Pastan, I -- Nakanishi, S -- New York, N.Y. -- Science. 2000 Jul 28;289(5479):633-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10915629" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*metabolism ; Animals ; Apomorphine/pharmacology ; Basal Ganglia/cytology/*physiology ; Choline O-Acetyltransferase/metabolism ; Corpus Striatum/cytology/*physiology ; Dopamine/*metabolism ; Dopamine Agonists/pharmacology ; Down-Regulation ; Enkephalins/genetics/metabolism ; Immunotoxins ; Interneurons/*physiology ; Mice ; Mice, Transgenic ; Motor Activity ; Oxidopamine/pharmacology ; Posture ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D2/metabolism ; Receptors, Glutamate/genetics/metabolism ; Substance P/genetics/metabolism ; Synapses/metabolism/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Logic circuits with carbon nanotube transistors (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-06
    Description: We demonstrate logic circuits with field-effect transistors based on single carbon nanotubes. Our device layout features local gates that provide excellent capacitive coupling between the gate and nanotube, enabling strong electrostatic doping of the nanotube from p-doping to n-doping and the study of the nonconventional long-range screening of charge along the one-dimensional nanotubes. The transistors show favorable device characteristics such as high gain (〉10), a large on-off ratio (〉10(5)), and room-temperature operation. Importantly, the local-gate layout allows for integration of multiple devices on a single chip. Indeed, we demonstrate one-, two-, and three-transistor circuits that exhibit a range of digital logic operations, such as an inverter, a logic NOR, a static random-access memory cell, and an ac ring oscillator.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bachtold, A -- Hadley, P -- Nakanishi, T -- Dekker, C -- New York, N.Y. -- Science. 2001 Nov 9;294(5545):1317-20. Epub 2001 Oct 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Physics, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11588220" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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  • 4
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    Movement of retinal along the visual transduction path (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-06-24
    Description: Movement of the ligand/receptor complex in rhodopsin (Rh) has been traced. Bleaching of diazoketo rhodopsin (DK-Rh) containing 11-cis-3-diazo-4-oxo-retinal yields batho-, lumi-, meta-I-, and meta-II-Rh intermediates corresponding to those of native Rh but at lower temperatures. Photoaffinity labeling of DK-Rh and these bleaching intermediates shows that the ionone ring cross-links to tryptophan-265 on helix F in DK-Rh and batho-Rh, and to alanine-169 on helix D in lumi-, meta-I-, and meta-II-Rh intermediates. It is likely that these movements involving a flip-over of the chromophoric ring trigger changes in cytoplasmic membrane loops resulting in heterotrimeric guanine nucleotide-binding protein (G protein) activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borhan, B -- Souto, M L -- Imai, H -- Shichida, Y -- Nakanishi, K -- GM34509/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Jun 23;288(5474):2209-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Columbia University, New York, NY 10027, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10864869" target="_blank"〉PubMed〈/a〉
    Keywords: Affinity Labels ; Azo Compounds/chemistry/*metabolism ; Binding Sites ; Circular Dichroism ; Heterotrimeric GTP-Binding Proteins/metabolism ; Ligands ; Light ; Models, Molecular ; Photolysis ; Protein Binding ; Protein Conformation ; Protein Structure, Secondary ; Retinaldehyde/analogs & derivatives/chemistry/*metabolism ; Rhodopsin/*analogs & derivatives/chemistry/*metabolism ; Rod Cell Outer Segment/*metabolism ; Stereoisomerism ; Temperature ; *Vision, Ocular
    Print ISSN: 0036-8075
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  • 5
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    Cloning of a membrane protein that induces a slow voltage-gated potassium current (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-11-18
    Description: A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takumi, T -- Ohkubo, H -- Nakanishi, S -- New York, N.Y. -- Science. 1988 Nov 18;242(4881):1042-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Immunology, Kyoto University Faculty of Medicine, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3194754" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Blotting, Northern ; Cloning, Molecular ; DNA/genetics ; Electric Conductivity ; Membrane Potentials ; Membrane Proteins/*genetics ; Molecular Sequence Data ; Molecular Weight ; Potassium Channels/*physiology ; Rats ; Xenopus laevis
    Print ISSN: 0036-8075
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  • 6
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    Intracellular signaling by 14-hydroxy-4,14-retro-retinol (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-12-13
    Description: In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buck, J -- Derguini, F -- Levi, E -- Nakanishi, K -- Hammerling, U -- AI38351/AI/NIAID NIH HHS/ -- CA49933/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1991 Dec 13;254(5038):1654-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1749937" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/physiology ; Cell Line ; Growth Substances ; Humans ; Magnetic Resonance Spectroscopy ; Mice ; Retinoids/*chemistry ; Second Messenger Systems ; Signal Transduction ; Spectrophotometry, Ultraviolet ; Vitamin A/*analogs & derivatives/chemistry/physiology
    Print ISSN: 0036-8075
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  • 7
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    Design and synthesis of a mimetic from an antibody complementarity-determining region (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-08-16
    Description: A technique for producing non-peptide compounds (mimetics) of designed specificities was developed that permitted the synthesis of a conformationally restricted molecule that mimicked the binding and functional properties of monoclonal antibody (MAb) 87.92.6, which recognizes the reovirus type 3 cellular receptor. Binding of either MAb 87.92.6, peptide analogs, or 87.1-mimetic to the cellular receptor inhibited cellular proliferation. The mimetic was a synthetic beta-loop structure that mimics the second complementarity-determining region of the MAb. These studies may lead to strategies for the synthetic design of antibody complementarity regions, ligands, and other pharmacologically active agents that are water soluble, resistant to proteolysis, and nonimmunogenic.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Saragovi, H U -- Fitzpatrick, D -- Raktabutr, A -- Nakanishi, H -- Kahn, M -- Greene, M I -- New York, N.Y. -- Science. 1991 Aug 16;253(5021):792-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1876837" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal/*chemistry ; Cell Division/drug effects ; Drug Design ; Endopeptidases/pharmacology ; Mammalian orthoreovirus 3 ; Models, Molecular ; Molecular Conformation ; Peptides/metabolism ; Piperidines/chemical synthesis/*chemistry/pharmacology ; Receptors, Virus/drug effects/*immunology/metabolism ; Structure-Activity Relationship
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  • 8
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    Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-07-10
    Description: The concentration of cytoplasmic free calcium (Ca2+) increases in various stimulated cells in a wave (Ca2+ wave) and in periodic transients (Ca2+ oscillations). These phenomena are explained by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release (CICR) from separate intracellular stores, but decisive evidence is lacking. A monoclonal antibody to the IP3 receptor inhibited both IICR and CICR upon injection of IP3 and Ca2+ into hamster eggs, respectively. The antibody completely blocked sperm-induced Ca2+ waves and Ca2+ oscillations. The results indicate that Ca2+ release in fertilized hamster eggs is mediated solely by the IP3 receptor, and Ca(2+)-sensitized IICR, but not CICR, generates Ca2+ waves and Ca2+ oscillations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Miyazaki, S -- Yuzaki, M -- Nakada, K -- Shirakawa, H -- Nakanishi, S -- Nakade, S -- Mikoshiba, K -- New York, N.Y. -- Science. 1992 Jul 10;257(5067):251-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Tokyo Women's Medical College, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1321497" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies, Monoclonal ; Caffeine/pharmacology ; Calcium/*metabolism ; *Calcium Channels ; Cricetinae ; Dose-Response Relationship, Drug ; Fertilization/*physiology ; Immunoblotting ; Inositol 1,4,5-Trisphosphate Receptors ; Male ; Ovum/*metabolism ; Receptors, Cell Surface/drug effects/*physiology ; *Receptors, Cytoplasmic and Nuclear ; Ryanodine/pharmacology ; Spermatozoa/physiology ; Time Factors
    Print ISSN: 0036-8075
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  • 9
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    Autistic phenotype from MEF2C knockout cells (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lipton, Stuart A -- Li, Hao -- Zaremba, Jeffrey D -- McKercher, Scott R -- Cui, Jiankun -- Kang, Yeon-Joo -- Nie, Zhiguo -- Soussou, Walid -- Talantova, Maria -- Okamoto, Shu-Ichi -- Nakanishi, Nobuki -- New York, N.Y. -- Science. 2009 Jan 9;323(5911):208. doi: 10.1126/science.323.5911.208b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19131610" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autistic Disorder/*genetics/*physiopathology ; Embryonic Stem Cells/physiology ; Gene Knockout Techniques ; MEF2 Transcription Factors ; Mice ; Mice, Knockout ; Myogenic Regulatory Factors/*genetics/*physiology ; *Neurogenesis ; Neurons/cytology/*physiology ; Phenotype ; Rett Syndrome/genetics/physiopathology ; Synapses/physiology
    Print ISSN: 0036-8075
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  • 10
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    Highly regioselective amination of unactivated alkanes by hypervalent sulfonylimino-lambda(3)-bromane (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-04-23
    Description: Amination of alkanes has generally required metal catalysts and/or high temperatures. Here we report that simple exposure of a broad range of alkanes to N-triflylimino-lambda(3)-bromane 1 at ambient temperature results in C-H insertion of the nitrogen functionality to afford triflyl-substituted amines in moderate to high yields. Marked selectivity for tertiary over secondary C-H bonds was observed; primary (methyl) C-H bonds were inert. Addition of hexafluoroisopropanol to inhibit decomposition of 1 dramatically improved the C-H amination efficiencies. Second-order kinetics, activation parameters (negative activation entropy), deuterium isotope effects, and theoretical calculations suggest a concerted asynchronous bimolecular transition state for the metal-free C-H amination event.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ochiai, Masahito -- Miyamoto, Kazunori -- Kaneaki, Takao -- Hayashi, Satoko -- Nakanishi, Waro -- New York, N.Y. -- Science. 2011 Apr 22;332(6028):448-51. doi: 10.1126/science.1201686.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate School of Pharmaceutical Sciences, University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan. mochiai@ph.tokushima-u.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21512029" target="_blank"〉PubMed〈/a〉
    Keywords: Adamantane/chemistry ; Alkanes/*chemistry ; Amination ; Amines/*chemistry ; Bromobenzenes/*chemistry ; Carbon/chemistry ; Hydrocarbons, Brominated/*chemistry ; Hydrogen/chemistry ; Kinetics ; Physicochemical Processes ; Stereoisomerism ; Temperature ; Thermodynamics
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