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    Impaired prion replication in spleens of mice lacking functional follicular dendritic cells (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-05-20
    Description: In scrapie-infected mice, prions are found associated with splenic but not circulating B and T lymphocytes and in the stroma, which contains follicular dendritic cells (FDCs). Formation and maintenance of mature FDCs require the presence of B cells expressing membrane-bound lymphotoxin-alpha/beta. Treatment of mice with soluble lymphotoxin-beta receptor results in the disappearance of mature FDCs from the spleen. We show that this treatment abolishes splenic prion accumulation and retards neuroinvasion after intraperitoneal scrapie inoculation. These data provide evidence that FDCs are the principal sites for prion replication in the spleen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Montrasio, F -- Frigg, R -- Glatzel, M -- Klein, M A -- Mackay, F -- Aguzzi, A -- Weissmann, C -- New York, N.Y. -- Science. 2000 May 19;288(5469):1257-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuropathology, Department of Pathology, University of Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10818004" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation/genetics/immunology ; Dendritic Cells, Follicular/metabolism/*pathology/*virology ; Immunoglobulins/genetics ; Lymphotoxin beta Receptor ; Lymphotoxin-alpha/antagonists & inhibitors/genetics/immunology ; Mice ; Mice, Inbred C57BL ; Mice, SCID ; PrPSc Proteins/administration & dosage/*biosynthesis ; Receptors, Tumor Necrosis Factor/antagonists & inhibitors/genetics/immunology ; Recombinant Fusion Proteins/administration & dosage ; Scrapie/immunology/metabolism ; Signal Transduction/genetics/immunology ; Spleen/immunology/metabolism/*pathology/*virology ; Virus Replication/genetics/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-08
    Description: Variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy are initiated by extracerebral exposure to prions. Although prion transmission from extracerebral sites to the brain represents a potential target for prophylaxis, attempts at vaccination have been limited by the poor immunogenicity of prion proteins. To circumvent this, we expressed an anti-prion protein (anti-PrP) mu chain in Prnp(o/o) mice. Transgenic mice developed sustained anti-PrP titers, which were not suppressed by introduction of Prnp+ alleles. Transgene expression prevented pathogenesis of prions introduced by intraperitoneal injection in the spleen and brain. Expression of endogenous PrP (PrP(C)) in the spleen and brain was unaffected, suggesting that immunity was responsible for protection. This indicates the feasibility of immunological inhibition of prion disease in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heppner, F L -- Musahl, C -- Arrighi, I -- Klein, M A -- Rulicke, T -- Oesch, B -- Zinkernagel, R M -- Kalinke, U -- Aguzzi, A -- New York, N.Y. -- Science. 2001 Oct 5;294(5540):178-82. Epub 2001 Sep 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuropathology, Institute of Laboratory Animal Science, Institute of Experimental Immunology, University Hospital Zurich, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11546838" target="_blank"〉PubMed〈/a〉
    Keywords: Amyloid/genetics ; Animals ; Antibodies/blood/*immunology ; B-Lymphocytes/immunology ; Blotting, Western ; Brain Chemistry ; Cell Separation ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Immunoglobulin M/blood/immunology ; Immunoglobulin mu-Chains/blood/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; PrPC Proteins/genetics ; PrPSc Proteins/analysis/*immunology ; Prions/genetics/*immunology ; Protein Precursors/genetics ; Scrapie/*prevention & control ; Spleen/chemistry/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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