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  • American Association for the Advancement of Science (AAAS)  (4)
  • 1
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    Dynamics of the 2001 UK foot and mouth epidemic: stochastic dispersal in a heterogeneous landscape (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-10-27
    Description: Foot-and-mouth is one of the world's most economically important livestock diseases. We developed an individual farm-based stochastic model of the current UK epidemic. The fine grain of the epidemiological data reveals the infection dynamics at an unusually high spatiotemporal resolution. We show that the spatial distribution, size, and species composition of farms all influence the observed pattern and regional variability of outbreaks. The other key dynamical component is long-tailed stochastic dispersal of infection, combining frequent local movements with occasional long jumps. We assess the history and possible duration of the epidemic, the performance of control strategies, and general implications for disease dynamics in space and time.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keeling, M J -- Woolhouse, M E -- Shaw, D J -- Matthews, L -- Chase-Topping, M -- Haydon, D T -- Cornell, S J -- Kappey, J -- Wilesmith, J -- Grenfell, B T -- New York, N.Y. -- Science. 2001 Oct 26;294(5543):813-7. Epub 2001 Oct 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. matt@zoo.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11679661" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Husbandry ; Animals ; Cattle ; Cattle Diseases/epidemiology/transmission ; Disease Outbreaks/*veterinary ; Disease Susceptibility/veterinary ; Foot-and-Mouth Disease/*epidemiology/prevention & control/transmission ; Foot-and-Mouth Disease Virus/immunology ; Great Britain/epidemiology ; Models, Biological ; *Models, Statistical ; Sheep ; Sheep Diseases/epidemiology/transmission ; Space-Time Clustering ; Stochastic Processes ; Vaccination/veterinary ; Viral Vaccines/administration & dosage
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Transformation of tooth type induced by inhibition of BMP signaling (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-11-06
    Description: Mammalian dentitions are highly patterned, with different types of teeth positioned in different regions of the jaws. BMP4 is an early oral epithelial protein signal that directs odontogenic gene expression in mesenchyme cells of the developing mandibular arch. BMP4 was shown to inhibit expression of the homeobox gene Barx-1 and to restrict expression to the proximal, presumptive molar mesenchyme of mouse embryos at embryonic day 10. The inhibition of BMP signaling early in mandible development by the action of exogenous Noggin protein resulted in ectopic Barx-1 expression in the distal, presumptive incisor mesenchyme and a transformation of tooth identity from incisor to molar.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tucker, A S -- Matthews, K L -- Sharpe, P T -- G9800001/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 1998 Nov 6;282(5391):1136-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Craniofacial Development, Guy's, King's, and St. Thomas' School of Dentistry, Guy's Hospital, London SE1 9RT, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9804553" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Patterning ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Proteins/*physiology ; Carrier Proteins ; Culture Techniques ; Gene Expression Regulation, Developmental ; *Genes, Homeobox ; Homeodomain Proteins/*genetics/physiology ; Incisor/*embryology ; MSX1 Transcription Factor ; Male ; Mandible/embryology ; Mesoderm/metabolism/transplantation ; Mice ; Molar/*embryology ; *Odontogenesis ; Oncogene Proteins/genetics ; Proteins/metabolism/pharmacology ; Signal Transduction ; Tooth Germ/embryology ; Transcription Factors/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Biochemistry. Remote enzyme microsurgery (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-03-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bollinger, J Martin Jr -- Matthews, Megan L -- New York, N.Y. -- Science. 2010 Mar 12;327(5971):1337-8. doi: 10.1126/science.1187421.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA. jmb21@psu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20223975" target="_blank"〉PubMed〈/a〉
    Keywords: Catalytic Domain ; Enzyme Precursors/*chemistry/*metabolism ; Hemeproteins/chemistry/*metabolism ; Hydroxylation ; Indolequinones/*metabolism ; Models, Chemical ; Oxidation-Reduction ; Oxidoreductases Acting on CH-NH Group Donors/*chemistry/*metabolism ; Protein Binding ; Protein Conformation ; *Protein Processing, Post-Translational ; Tryptophan/*analogs & derivatives/chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Demonstration of X-ray Holography with an X-ray Laser (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-10-23
    Description: An x-ray hologram was made by means of an x-ray laser and a laser-quality near normal incidence x-ray mirror. The high brightness and large coherence lengths of x-ray lasers now offer the potential for in vitro three-dimensional high-resolution holographic images of dynamically varying biological microstructures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Trebes, J E -- Brown, S B -- Campbell, E M -- Matthews, D L -- Nilson, D G -- Stone, G F -- Whelan, D A -- New York, N.Y. -- Science. 1987 Oct 23;238(4826):517-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17809616" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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