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  • 1
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    ECOLOGY: Louisiana's Vanishing Wetlands: Going, Going (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-09-11
    Description: An ambitious $14 billion plan known as Coast 2050 attempts to protect more than 10,000 square kilometers of Louisiana's wetlands, which are disappearing at a rate of up to 90 square kilometers per year, one of the highest rates of land loss in the world. But a number of unanswered scientific questions swirl around the plan. And it could run afoul of powerful interests in the shipping, petroleum, and fishing industries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bourne, J -- New York, N.Y. -- Science. 2000 Sep 15;289(5486):1860-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17839927" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Online education today (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-03
    Description: Online education is established, growing, and here to stay. It is creating new opportunities for students and also for faculty, regulators of education, and the educational institutions themselves. Much of what is being learned by the practitioners will flow into the large numbers of blended courses that will be developed and delivered on most campuses. Some of what is being learned will certainly improve pedagogical approaches and possibly affect other important problems, such as the lengthening time to completion of a degree. Online education is already providing better access to education for many, and many more will benefit from this increased access in the coming years.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mayadas, A Frank -- Bourne, John -- Bacsich, Paul -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):85-9. doi: 10.1126/science.1168874.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Alfred P. Sloan Foundation, 630 Fifth Avenue, New York, NY 10111, USA. mayadas@sloan.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119225" target="_blank"〉PubMed〈/a〉
    Keywords: Computer-Assisted Instruction/economics ; *Education, Distance/economics ; Faculty ; Federal Government ; Humans ; *Internet ; Online Systems ; State Government ; Students ; Training Support ; United States ; *Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination (2018)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2018-04-13
    Description: Antibodies have the specificity to differentiate foreign antigens that mimic self antigens, but it remains unclear how such specificity is acquired. In a mouse model, we generated B cells displaying an antibody that cross-reacts with two related protein antigens expressed on self versus foreign cells. B cell anergy was imposed by self antigen but reversed upon challenge with high-density foreign antigen, leading to germinal center recruitment and antibody gene hypermutation. Single-cell analysis detected rapid selection for mutations that decrease self affinity and slower selection for epistatic mutations that specifically increase foreign affinity. Crystal structures revealed that these mutations exploited subtle topological differences to achieve 5000-fold preferential binding to foreign over self epitopes. Resolution of antigenic mimicry drove the optimal affinity maturation trajectory, highlighting the value of retaining self-reactive clones as substrates for protective antibody responses.
    Keywords: Cell Biology, Immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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