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  • 1
    Publication Date: 2002-11-02
    Description: Stabilizing the carbon dioxide-induced component of climate change is an energy problem. Establishment of a course toward such stabilization will require the development within the coming decades of primary energy sources that do not emit carbon dioxide to the atmosphere, in addition to efforts to reduce end-use energy demand. Mid-century primary power requirements that are free of carbon dioxide emissions could be several times what we now derive from fossil fuels (approximately 10(13) watts), even with improvements in energy efficiency. Here we survey possible future energy sources, evaluated for their capability to supply massive amounts of carbon emission-free energy and for their potential for large-scale commercialization. Possible candidates for primary energy sources include terrestrial solar and wind energy, solar power satellites, biomass, nuclear fission, nuclear fusion, fission-fusion hybrids, and fossil fuels from which carbon has been sequestered. Non-primary power technologies that could contribute to climate stabilization include efficiency improvements, hydrogen production, storage and transport, superconducting global electric grids, and geoengineering. All of these approaches currently have severe deficiencies that limit their ability to stabilize global climate. We conclude that a broad range of intensive research and development is urgently needed to produce technological options that can allow both climate stabilization and economic development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hoffert, Martin I -- Caldeira, Ken -- Benford, Gregory -- Criswell, David R -- Green, Christopher -- Herzog, Howard -- Jain, Atul K -- Kheshgi, Haroon S -- Lackner, Klaus S -- Lewis, John S -- Lightfoot, H Douglas -- Manheimer, Wallace -- Mankins, John C -- Mauel, Michael E -- Perkins, L John -- Schlesinger, Michael E -- Volk, Tyler -- Wigley, Tom M L -- New York, N.Y. -- Science. 2002 Nov 1;298(5595):981-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, New York University, New York, NY 10003, USA. marty.hoffert@nyu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12411695" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1999-07-03
    Description: Two main types of material survive from the Canyon Diablo impactor, which produced Meteor Crater in Arizona: iron meteorites, which did not melt during the impact; and spheroids, which did. Ultrasensitive measurements using accelerator mass spectrometry show that the meteorites contain about seven times as much nickel-59 as the spheroids. Lower average nickel-59 contents in the spheroids indicate that they typically came from 0.5 to 1 meter deeper in the impactor than did the meteorites. Numerical modeling for an impact velocity of 20 kilometers per second shows that a shell 1.5 to 2 meters thick, corresponding to 16 percent of the projectile volume, remained solid on the rear surface; that most of the projectile melted; and that little, if any, vaporized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schnabel -- Pierazzo -- Xue -- Herzog -- Masarik -- Cresswell -- di Tada ML -- Liu -- Fifield -- New York, N.Y. -- Science. 1999 Jul 2;285(5424):85-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Rutgers University, Piscataway, NJ 08854, USA. Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 87521, USA. Graduate School of Oceanography, Narragansett Bay Campus, University of Rhode Island, Narraganse.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10390367" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-02-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plous, S -- Herzog, H A -- New York, N.Y. -- Science. 2000 Oct 27;290(5492):711.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11184195" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Welfare/*legislation & jurisprudence ; Animals ; *Animals, Laboratory ; Birds ; Mice ; Rats ; *Research Personnel ; Surveys and Questionnaires ; United States ; United States Department of Agriculture/legislation & jurisprudence
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    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2007-09-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plous, S -- Herzog, H A -- New York, N.Y. -- Science. 2000 Oct 27;290(5492):711b.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17780508" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 5
    Publication Date: 2000-07-21
    Description: Universal positive correlations between different cognitive tests motivate the concept of "general intelligence" or Spearman's g. Here the neural basis for g is investigated by means of positron emission tomography. Spatial, verbal, and perceptuo-motor tasks with high-g involvement are compared with matched low-g control tasks. In contrast to the common view that g reflects a broad sample of major cognitive functions, high-g tasks do not show diffuse recruitment of multiple brain regions. Instead they are associated with selective recruitment of lateral frontal cortex in one or both hemispheres. Despite very different task content in the three high-g-low-g contrasts, lateral frontal recruitment is markedly similar in each case. Many previous experiments have shown these same frontal regions to be recruited by a broad range of different cognitive demands. The results suggest that "general intelligence" derives from a specific frontal system important in the control of diverse forms of behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Duncan, J -- Seitz, R J -- Kolodny, J -- Bor, D -- Herzog, H -- Ahmed, A -- Newell, F N -- Emslie, H -- New York, N.Y. -- Science. 2000 Jul 21;289(5478):457-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK. john.duncan@mrc-cbu.cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10903207" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Brain Mapping ; *Cognition ; Frontal Lobe/blood supply/*physiology/radionuclide imaging ; Humans ; *Intelligence ; Intelligence Tests ; Middle Aged ; Psychomotor Performance ; Recruitment, Neurophysiological ; Tomography, Emission-Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-07-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Plous, S -- Herzog, H -- New York, N.Y. -- Science. 2001 Jul 27;293(5530):608-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Wesleyan University, Middletown, CT 06459-0408, USA. splous@wesleyan.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11474086" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Welfare ; Animals ; *Animals, Laboratory ; Behavior, Animal ; Peer Review, Research/*standards ; Reproducibility of Results ; Research/*standards ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
    Publication Date: 2006-12-16
    Description: The Stardust spacecraft collected thousands of particles from comet 81P/Wild 2 and returned them to Earth for laboratory study. The preliminary examination of these samples shows that the nonvolatile portion of the comet is an unequilibrated assortment of materials that have both presolar and solar system origin. The comet contains an abundance of silicate grains that are much larger than predictions of interstellar grain models, and many of these are high-temperature minerals that appear to have formed in the inner regions of the solar nebula. Their presence in a comet proves that the formation of the solar system included mixing on the grandest scales.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brownlee, Don -- Tsou, Peter -- Aleon, Jerome -- Alexander, Conel M O'd -- Araki, Tohru -- Bajt, Sasa -- Baratta, Giuseppe A -- Bastien, Ron -- Bland, Phil -- Bleuet, Pierre -- Borg, Janet -- Bradley, John P -- Brearley, Adrian -- Brenker, F -- Brennan, Sean -- Bridges, John C -- Browning, Nigel D -- Brucato, John R -- Bullock, E -- Burchell, Mark J -- Busemann, Henner -- Butterworth, Anna -- Chaussidon, Marc -- Cheuvront, Allan -- Chi, Miaofang -- Cintala, Mark J -- Clark, B C -- Clemett, Simon J -- Cody, George -- Colangeli, Luigi -- Cooper, George -- Cordier, Patrick -- Daghlian, C -- Dai, Zurong -- D'Hendecourt, Louis -- Djouadi, Zahia -- Dominguez, Gerardo -- Duxbury, Tom -- Dworkin, Jason P -- Ebel, Denton S -- Economou, Thanasis E -- Fakra, Sirine -- Fairey, Sam A J -- Fallon, Stewart -- Ferrini, Gianluca -- Ferroir, T -- Fleckenstein, Holger -- Floss, Christine -- Flynn, George -- Franchi, Ian A -- Fries, Marc -- Gainsforth, Z -- Gallien, J-P -- Genge, Matt -- Gilles, Mary K -- Gillet, Philipe -- Gilmour, Jamie -- Glavin, Daniel P -- Gounelle, Matthieu -- Grady, Monica M -- Graham, Giles A -- Grant, P G -- Green, Simon F -- Grossemy, Faustine -- Grossman, Lawrence -- Grossman, Jeffrey N -- Guan, Yunbin -- Hagiya, Kenji -- Harvey, Ralph -- Heck, Philipp -- Herzog, Gregory F -- Hoppe, Peter -- Horz, Friedrich -- Huth, Joachim -- Hutcheon, Ian D -- Ignatyev, Konstantin -- Ishii, Hope -- Ito, Motoo -- Jacob, Damien -- Jacobsen, Chris -- Jacobsen, Stein -- Jones, Steven -- Joswiak, David -- Jurewicz, Amy -- Kearsley, Anton T -- Keller, Lindsay P -- Khodja, H -- Kilcoyne, A L David -- Kissel, Jochen -- Krot, Alexander -- Langenhorst, Falko -- Lanzirotti, Antonio -- Le, Loan -- Leshin, Laurie A -- Leitner, J -- Lemelle, L -- Leroux, Hugues -- Liu, Ming-Chang -- Luening, K -- Lyon, Ian -- Macpherson, Glen -- Marcus, Matthew A -- Marhas, Kuljeet -- Marty, Bernard -- Matrajt, Graciela -- McKeegan, Kevin -- Meibom, Anders -- Mennella, Vito -- Messenger, Keiko -- Messenger, Scott -- Mikouchi, Takashi -- Mostefaoui, Smail -- Nakamura, Tomoki -- Nakano, T -- Newville, M -- Nittler, Larry R -- Ohnishi, Ichiro -- Ohsumi, Kazumasa -- Okudaira, Kyoko -- Papanastassiou, Dimitri A -- Palma, Russ -- Palumbo, Maria E -- Pepin, Robert O -- Perkins, David -- Perronnet, Murielle -- Pianetta, P -- Rao, William -- Rietmeijer, Frans J M -- Robert, Francois -- Rost, D -- Rotundi, Alessandra -- Ryan, Robert -- Sandford, Scott A -- Schwandt, Craig S -- See, Thomas H -- Schlutter, Dennis -- Sheffield-Parker, J -- Simionovici, Alexandre -- Simon, Steven -- Sitnitsky, I -- Snead, Christopher J -- Spencer, Maegan K -- Stadermann, Frank J -- Steele, Andrew -- Stephan, Thomas -- Stroud, Rhonda -- Susini, Jean -- Sutton, S R -- Suzuki, Y -- Taheri, Mitra -- Taylor, Susan -- Teslich, Nick -- Tomeoka, Kazu -- Tomioka, Naotaka -- Toppani, Alice -- Trigo-Rodriguez, Josep M -- Troadec, David -- Tsuchiyama, Akira -- Tuzzolino, Anthony J -- Tyliszczak, Tolek -- Uesugi, K -- Velbel, Michael -- Vellenga, Joe -- Vicenzi, E -- Vincze, L -- Warren, Jack -- Weber, Iris -- Weisberg, Mike -- Westphal, Andrew J -- Wirick, Sue -- Wooden, Diane -- Wopenka, Brigitte -- Wozniakiewicz, Penelope -- Wright, Ian -- Yabuta, Hikaru -- Yano, Hajime -- Young, Edward D -- Zare, Richard N -- Zega, Thomas -- Ziegler, Karen -- Zimmerman, Laurent -- Zinner, Ernst -- Zolensky, Michael -- New York, N.Y. -- Science. 2006 Dec 15;314(5806):1711-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Astronomy, University of Washington, Seattle, WA 98195, USA. brownlee@astro.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17170289" target="_blank"〉PubMed〈/a〉
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  • 8
    Publication Date: 2006-12-16
    Description: We measured the elemental compositions of material from 23 particles in aerogel and from residue in seven craters in aluminum foil that was collected during passage of the Stardust spacecraft through the coma of comet 81P/Wild 2. These particles are chemically heterogeneous at the largest size scale analyzed ( approximately 180 ng). The mean elemental composition of this Wild 2 material is consistent with the CI meteorite composition, which is thought to represent the bulk composition of the solar system, for the elements Mg, Si, Mn, Fe, and Ni to 35%, and for Ca and Ti to 60%. The elements Cu, Zn, and Ga appear enriched in this Wild 2 material, which suggests that the CI meteorites may not represent the solar system composition for these moderately volatile minor elements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Flynn, George J -- Bleuet, Pierre -- Borg, Janet -- Bradley, John P -- Brenker, Frank E -- Brennan, Sean -- Bridges, John -- Brownlee, Don E -- Bullock, Emma S -- Burghammer, Manfred -- Clark, Benton C -- Dai, Zu Rong -- Daghlian, Charles P -- Djouadi, Zahia -- Fakra, Sirine -- Ferroir, Tristan -- Floss, Christine -- Franchi, Ian A -- Gainsforth, Zack -- Gallien, Jean-Paul -- Gillet, Philippe -- Grant, Patrick G -- Graham, Giles A -- Green, Simon F -- Grossemy, Faustine -- Heck, Philipp R -- Herzog, Gregory F -- Hoppe, Peter -- Horz, Friedrich -- Huth, Joachim -- Ignatyev, Konstantin -- Ishii, Hope A -- Janssens, Koen -- Joswiak, David -- Kearsley, Anton T -- Khodja, Hicham -- Lanzirotti, Antonio -- Leitner, Jan -- Lemelle, Laurence -- Leroux, Hugues -- Luening, Katharina -- Macpherson, Glenn J -- Marhas, Kuljeet K -- Marcus, Matthew A -- Matrajt, Graciela -- Nakamura, Tomoki -- Nakamura-Messenger, Keiko -- Nakano, Tsukasa -- Newville, Matthew -- Papanastassiou, Dimitri A -- Pianetta, Piero -- Rao, William -- Riekel, Christian -- Rietmeijer, Frans J M -- Rost, Detlef -- Schwandt, Craig S -- See, Thomas H -- Sheffield-Parker, Julie -- Simionovici, Alexandre -- Sitnitsky, Ilona -- Snead, Christopher J -- Stadermann, Frank J -- Stephan, Thomas -- Stroud, Rhonda M -- Susini, Jean -- Suzuki, Yoshio -- Sutton, Stephen R -- Taylor, Susan -- Teslich, Nick -- Troadec, D -- Tsou, Peter -- Tsuchiyama, Akira -- Uesugi, Kentaro -- Vekemans, Bart -- Vicenzi, Edward P -- Vincze, Laszlo -- Westphal, Andrew J -- Wozniakiewicz, Penelope -- Zinner, Ernst -- Zolensky, Michael E -- New York, N.Y. -- Science. 2006 Dec 15;314(5806):1731-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, State University of New York at Plattsburgh, 101 Broad Street, Plattsburgh, NY 12901, USA. george.flynn@plattsburgh.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17170294" target="_blank"〉PubMed〈/a〉
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  • 9
    Publication Date: 2009-03-17
    Description: Once all chromosomes are connected to the mitotic spindle (bioriented), anaphase is initiated by the protein ubiquitylation activity of the anaphase-promoting complex/cyclosome (APC/C) and its coactivator Cdc20 (APC/C(Cdc20)). Before chromosome biorientation, anaphase is delayed by a mitotic checkpoint complex (MCC) that inhibits APC/C(Cdc20). We used single-particle electron microscopy to obtain three-dimensional models of human APC/C in various functional states: bound to MCC, to Cdc20, or to neither (apo-APC/C). These experiments revealed that MCC associates with the Cdc20 binding site on APC/C, locks the otherwise flexible APC/C in a "closed" state, and prevents binding and ubiquitylation of a wide range of different APC/C substrates. These observations clarify the structural basis for the inhibition of APC/C by spindle checkpoint proteins.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989460/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989460/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herzog, Franz -- Primorac, Ivana -- Dube, Prakash -- Lenart, Peter -- Sander, Bjorn -- Mechtler, Karl -- Stark, Holger -- Peters, Jan-Michael -- F 3407/Austrian Science Fund FWF/Austria -- New York, N.Y. -- Science. 2009 Mar 13;323(5920):1477-81. doi: 10.1126/science.1163300.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19286556" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase ; Anaphase-Promoting Complex-Cyclosome ; Cdc20 Proteins ; Cell Cycle Proteins/chemistry/metabolism ; HeLa Cells ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Microscopy, Electron ; *Mitosis ; Models, Molecular ; Protein Binding ; Protein Conformation ; Protein Structure, Tertiary ; Spindle Apparatus/*metabolism ; Ubiquitin-Conjugating Enzymes/chemistry/metabolism ; Ubiquitin-Protein Ligase Complexes/*chemistry/*metabolism ; Ubiquitination
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  • 10
    Publication Date: 2012-09-18
    Description: The identification of proximate amino acids by chemical cross-linking and mass spectrometry (XL-MS) facilitates the structural analysis of homogeneous protein complexes. We gained distance restraints on a modular interaction network of protein complexes affinity-purified from human cells by applying an adapted XL-MS protocol. Systematic analysis of human protein phosphatase 2A (PP2A) complexes identified 176 interprotein and 570 intraprotein cross-links that link specific trimeric PP2A complexes to a multitude of adaptor proteins that control their cellular functions. Spatial restraints guided molecular modeling of the binding interface between immunoglobulin binding protein 1 (IGBP1) and PP2A and revealed the topology of TCP1 ring complex (TRiC) chaperonin interacting with the PP2A regulatory subunit 2ABG. This study establishes XL-MS as an integral part of hybrid structural biology approaches for the analysis of endogenous protein complexes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herzog, Franz -- Kahraman, Abdullah -- Boehringer, Daniel -- Mak, Raymond -- Bracher, Andreas -- Walzthoeni, Thomas -- Leitner, Alexander -- Beck, Martin -- Hartl, Franz-Ulrich -- Ban, Nenad -- Malmstrom, Lars -- Aebersold, Ruedi -- New York, N.Y. -- Science. 2012 Sep 14;337(6100):1348-52. doi: 10.1126/science.1221483.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Institute of Molecular Systems Biology, Eidgenossische Technische Hochschule Zurich, Wolfgang-Pauli Strasse 16, 8093 Zurich, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22984071" target="_blank"〉PubMed〈/a〉
    Keywords: Chaperonins/chemistry ; Cross-Linking Reagents/chemistry ; Crystallography, X-Ray ; Humans ; Mass Spectrometry/*methods ; *Metabolic Networks and Pathways ; Protein Conformation ; Protein Interaction Mapping/*methods ; Protein Phosphatase 2/*chemistry
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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