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  • 1
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    Lack of protective immunity against reinfection with hepatitis C virus (1992)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1992-10-02
    Description: Some individuals infected with hepatitis C virus (HCV) experience multiple episodes of acute hepatitis. It is unclear whether these episodes are due to reinfection with HCV or to reactivation of the original virus infection. Markers of viral replication and host immunity were studied in five chimpanzees sequentially inoculated over a period of 3 years with different HCV strains of proven infectivity. Each rechallenge of a convalescent chimpanzee with the same or a different HCV strain resulted in the reappearance of viremia, which was due to infection with the subsequent challenge virus. The evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Farci, P -- Alter, H J -- Govindarajan, S -- Wong, D C -- Engle, R -- Lesniewski, R R -- Mushahwar, I K -- Desai, S M -- Miller, R H -- Ogata, N -- New York, N.Y. -- Science. 1992 Oct 2;258(5079):135-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Hepatitis Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1279801" target="_blank"〉PubMed〈/a〉
    Keywords: Acute Disease ; Aged ; Alanine Transaminase/biosynthesis ; Animals ; Base Sequence ; Hepacivirus/physiology ; Hepatitis Antibodies/biosynthesis ; Hepatitis C/*immunology ; Hepatitis C Antibodies ; Humans ; Immunity, Active ; Longitudinal Studies ; Molecular Sequence Data ; Pan troglodytes ; Polymerase Chain Reaction ; Sequence Homology ; Transcription, Genetic ; Viremia ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The long noncoding RNA SPRIGHTLY acts as an intranuclear organizing hub for pre-mRNA molecules (2017)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2017-05-04
    Description: Molecular mechanisms by which long noncoding RNA (lncRNA) molecules may influence cancerous condition are poorly understood. The aberrant expression of SPRIGHTLY lncRNA, encoded within the drosophila gene homolog Sprouty-4 intron, is correlated with a variety of cancers, including human melanomas. We demonstrate by SHAPE-seq and dChIRP that SPRIGHTLY RNA secondary structure has a core pseudoknotted domain. This lncRNA interacts with the intronic regions of six pre-mRNAs: SOX5 , SMYD3 , SND1 , MEOX2 , DCTN6 , and RASAL2 , all of which have cancer-related functions. Hemizygous knockout of SPRIGHTLY by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 in melanoma cells significantly decreases SPRIGHTLY lncRNA levels, simultaneously decreases the levels of its interacting pre-mRNA molecules, and decreases anchorage-independent growth rate of cells and the rate of in vivo tumor growth in mouse xenografts. These results provide the first demonstration of an lncRNA’s three-dimensional coordinating role in facilitating cancer-related gene expression in human melanomas.
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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