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  • 1
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    Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-07-17
    Description: The paucity of virus-laden CD4+ cells in individuals infected with human immunodeficiency virus type-1 (HIV-1) contrasts with the greatly reduced numbers and function of these lymphocytes. A pathway is described whereby dendritic cells carry HIV-1 to uninfected T cells, amplifying the cytopathic effects of small amounts of virus. After exposure to HIV-1, dendritic cells continue to present superantigens and antigens, forming clusters with T cells that are driven to replicate. Infection of the dendritic cells cannot be detected, but the clustered T cells form syncytia, release virions, and die. Carriage of HIV-1 by dendritic cells may facilitate the lysis and loss of antigen specific CD4+ T cells in acquired immunodeficiency syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cameron, P U -- Freudenthal, P S -- Barker, J M -- Gezelter, S -- Inaba, K -- Steinman, R M -- AI 24775/AI/NIAID NIH HHS/ -- MOI-RR00102/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1992 Jul 17;257(5068):383-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1352913" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/drug therapy/*transmission ; Animals ; Antigen-Presenting Cells/immunology ; CD4-Positive T-Lymphocytes/*immunology/*microbiology ; Cell Separation ; Dendritic Cells/*immunology/*microbiology ; Flow Cytometry ; HIV Core Protein p24/biosynthesis ; HIV Long Terminal Repeat/physiology ; HIV-1/*pathogenicity ; In Vitro Techniques ; Lymphocyte Culture Test, Mixed ; Mice ; Microscopy, Electron ; Polymerase Chain Reaction ; Zidovudine/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Herapathite (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-06-13
    Description: Herapathite crystals were first prepared when an assistant to the toxicologist Herapath mixed iodine with the urine of a quinine-fed dog. Herapath was shocked when his transparent crystals sitting one atop the other at right angles were "black as midnight" and predicted that they would replace costly mineral polarizers. Such a change in practice in optics had to await Land, who oriented fragile herapathite microcrystals in extruded polymers, a process that produced the first large-aperture light polarizers and, in turn, the Polaroid empire. Curiously, the crystal structure of herapathite has never been established, and thus its chromophore and mechanism of action remain a mystery. The single crystal structure of herapathite is herein established, and its complete dichroism can be attributed to delocalized excitations along ...I3-...I3-... chains. The workings of herapathite, one of the most successful serendipitously engineered crystals, is only now understood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kahr, Bart -- Freudenthal, John -- Phillips, Shane -- Kaminsky, Werner -- New York, N.Y. -- Science. 2009 Jun 12;324(5933):1407. doi: 10.1126/science.1173605.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Box 351700, University of Washington, Seattle, WA 98195-1700, USA. bart.kahr@nyu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19520951" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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