Publication Date:
1978-02-24
Description:
Bityrosine was isolated from the insoluble protein of human cataractous lenses. Identification was based on correspondence with synthetic bityrosine with respect to chromatography, fluorescence, and ultraviolet and mass spectra. It is suggested that the compound may form cross-links with polypeptide chains in old and cataractous lenses, causing significant alteration in native protein structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Garcia-Castineiras, S -- Dillon, J -- Spector, A -- New York, N.Y. -- Science. 1978 Feb 24;199(4331):897-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622574" target="_blank"〉PubMed〈/a〉
Keywords:
*Cataract
;
Crystallins/*analysis
;
Dipeptides/*analysis
;
Humans
;
Lens, Crystalline/*analysis
;
Spectrometry, Fluorescence
;
Tyrosine/*analogs & derivatives/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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