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  • 1
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    A draft sequence of the rice genome (Oryza sativa L. ssp. japonica) (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-06
    Description: The genome of the japonica subspecies of rice, an important cereal and model monocot, was sequenced and assembled by whole-genome shotgun sequencing. The assembled sequence covers 93% of the 420-megabase genome. Gene predictions on the assembled sequence suggest that the genome contains 32,000 to 50,000 genes. Homologs of 98% of the known maize, wheat, and barley proteins are found in rice. Synteny and gene homology between rice and the other cereal genomes are extensive, whereas synteny with Arabidopsis is limited. Assignment of candidate rice orthologs to Arabidopsis genes is possible in many cases. The rice genome sequence provides a foundation for the improvement of cereals, our most important crops.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goff, Stephen A -- Ricke, Darrell -- Lan, Tien-Hung -- Presting, Gernot -- Wang, Ronglin -- Dunn, Molly -- Glazebrook, Jane -- Sessions, Allen -- Oeller, Paul -- Varma, Hemant -- Hadley, David -- Hutchison, Don -- Martin, Chris -- Katagiri, Fumiaki -- Lange, B Markus -- Moughamer, Todd -- Xia, Yu -- Budworth, Paul -- Zhong, Jingping -- Miguel, Trini -- Paszkowski, Uta -- Zhang, Shiping -- Colbert, Michelle -- Sun, Wei-lin -- Chen, Lili -- Cooper, Bret -- Park, Sylvia -- Wood, Todd Charles -- Mao, Long -- Quail, Peter -- Wing, Rod -- Dean, Ralph -- Yu, Yeisoo -- Zharkikh, Andrey -- Shen, Richard -- Sahasrabudhe, Sudhir -- Thomas, Alun -- Cannings, Rob -- Gutin, Alexander -- Pruss, Dmitry -- Reid, Julia -- Tavtigian, Sean -- Mitchell, Jeff -- Eldredge, Glenn -- Scholl, Terri -- Miller, Rose Mary -- Bhatnagar, Satish -- Adey, Nils -- Rubano, Todd -- Tusneem, Nadeem -- Robinson, Rosann -- Feldhaus, Jane -- Macalma, Teresita -- Oliphant, Arnold -- Briggs, Steven -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):92-100.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, CA 92121, USA. stephen.goff@syngenta.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11935018" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/genetics ; Chromosome Mapping ; Chromosomes/genetics ; Computational Biology ; Conserved Sequence ; DNA, Plant/genetics ; Databases, Nucleic Acid ; Edible Grain/genetics ; Gene Duplication ; Genes, Plant ; *Genome, Plant ; Genomics ; Oryza/*genetics/metabolism/physiology ; Phosphate Transport Proteins/genetics ; Plant Diseases ; Plant Proteins/chemistry/genetics ; Plant Structures/genetics ; Repetitive Sequences, Nucleic Acid ; *Sequence Analysis, DNA ; Sequence Homology, Nucleic Acid ; Software ; Synteny ; Transcription Factors/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The human polyomavirus, JCV, uses serotonin receptors to infect cells (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-20
    Description: The human polyomavirus, JCV, causes the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised patients. We found that the serotonergic receptor 5HT2AR could act as the cellular receptor for JCV on human glial cells. The 5HT2A receptor antagonists inhibited JCV infection, and monoclonal antibodies directed at 5HT2A receptors blocked infection of glial cells by JCV, but not by SV40. Transfection of 5HT2A receptor-negative HeLa cells with a 5HT2A receptor rescued virus infection, and this infection was blocked by antibody to the 5HT2A receptor. A tagged 5HT2A receptor colocalized with labeled JCV in an endosomal compartment following internalization. Serotonin receptor antagonists may thus be useful in the treatment of progressive multifocal leukoencephalopathy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Elphick, Gwendolyn F -- Querbes, William -- Jordan, Joslynn A -- Gee, Gretchen V -- Eash, Sylvia -- Manley, Kate -- Dugan, Aisling -- Stanifer, Megan -- Bhatnagar, Anushree -- Kroeze, Wesley K -- Roth, Bryan L -- Atwood, Walter J -- R01 CA71878/CA/NCI NIH HHS/ -- R01 NS43097/NS/NINDS NIH HHS/ -- R01MH57635/MH/NIMH NIH HHS/ -- R01MH61887/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2004 Nov 19;306(5700):1380-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15550673" target="_blank"〉PubMed〈/a〉
    Keywords: Antibodies, Monoclonal ; Cell Line, Transformed ; Dopamine Agonists/pharmacology ; Dopamine Antagonists/pharmacology ; Endosomes/metabolism/virology ; Flow Cytometry ; Fluorescent Antibody Technique, Indirect ; HeLa Cells ; Humans ; JC Virus/*physiology ; Microscopy, Confocal ; Neuroglia/physiology/*virology ; Receptor, Serotonin, 5-HT2A/immunology/*physiology ; Receptors, Dopamine/immunology/physiology ; Receptors, Virus/*physiology ; Serotonin/pharmacology ; Serotonin 5-HT2 Receptor Antagonists ; Serotonin Antagonists/pharmacology ; Sialic Acids/physiology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    The Global Oscillation Network Group (GONG) Project (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-05-31
    Description: Helioseismology requires nearly continuous observations of the oscillations of the solar surface for long periods of time in order to obtain precise measurements of the sun's normal modes of oscillation. The GONG project acquires velocity images from a network of six identical instruments distributed around the world. The GONG network began full operation in October 1995. It has achieved a duty cycle of 89 percent and reduced the magnitude of spectral artifacts by a factor of 280 in power, compared with single-site observations. The instrumental noise is less than the observed solar background.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harvey -- Hill -- Hubbard -- Kennedy -- Leibacher -- Pintar -- Gilman -- Noyes -- Title -- Toomre -- Ulrich -- Bhatnagar -- Kennewell -- Marquette -- Patron -- Saa -- Yasukawa -- New York, N.Y. -- Science. 1996 May 31;272(5266):1284-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉J. W. Harvey, F. Hill, R. P. Hubbard, J. R. Kennedy, J. W. Leibacher, and J. A. Pintar are with the National Solar Observatory, National Optical Astronomy Observatories, Post Office Box 26732, Tucson, AZ 85726-6732, USA. P. A. Gilman is with the High Altitude Observatory, National Center for Atmospheric Research, Post Office Box 3000, Boulder, CO 80307, USA. R. W. Noyes is with the Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138, USA. A. M. Title is with the Lockheed Solar and Astrophysics Laboratory, Palo Alto, CA 94304, USA. J. Toomre is with JILA, University of Colorado, Boulder, CO 80309, USA. R. K. Ulrich is with the Department of Physics and Astronomy, University of California, Los Angeles, CA 90024, USA. A. Bhatnagar is with the Udaipur Solar Observatory, Physical Research Laboratory, Udaipur, India. J. A. Kennewell is with the Learmonth Solar Observatory, IPS Radio and Space Services, Exmouth, Western Australia, Australia. W. Marquette is with the Big Bear Solar Observatory, Big Bear City, CA 92314, and California Institute of Technology, 264-33, Pasadena, CA 91125, USA. J. Patron is with the Observatorio del Teide, Instituto Astrofisica de Canarias, La Laguna, Tenerife, Spain. O. Saa is with the Cerro Tololo Interamerican Observatory, National Optical Astronomy Observatories, La Serena, Chile. E. Yasukawa is with the Mauna Loa Solar Observatory, Hilo, HI 96720, and High Altitude Observatory, National Center for Atmospheric Research, Post Office Box 3000, Boulder, CO 80307, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8662455" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Minorities in science: the dialogue (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-02-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McCarter, J -- Schreiber, M -- Bhatnagar, R -- New York, N.Y. -- Science. 1993 Feb 19;259(5098):1108.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17794375" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Effect of neonatal handling on age-related impairments associated with the hippocampus (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-02-12
    Description: In rats, an environmental manipulation occurring early in life resulted in changes in the adrenocortical axis that persisted throughout the entire life of the animals and attenuated certain deficits associated with aging. Rats handled during infancy had a permanent increase in concentrations of receptors for glucocorticoids in the hippocampus, a critical region in the negative-feedback inhibition of adrenocortical activity. Increased receptor concentrations led to greater hippocampal sensitivity to glucocorticoids and enhanced negative-feedback efficacy in the handled rats. Thus, at all ages tested, rats that were not handled secreted more glucocorticoids in response to stress than did handled rats. At later ages, nonhandled rats also showed elevated basal glucocorticoid levels, with the result that there was a greater cumulative exposure to glucocorticoids in nonhandled rats. Increased exposure to adrenal glucocorticoids can accelerate hippocampal neuron loss and cognitive impairments in aging. Hippocampal cell loss and pronounced spatial memory deficits emerged with age in the nonhandled rats, but were almost absent in the handled rats. Previous work showed that glucocorticoid hypersecretion, hippocampal neuron death, and cognitive impairments form a complex degenerative cascade of aging in the rat. The present study shows that a subtle manipulation early in life can retard the emergence of this cascade.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meaney, M J -- Aitken, D H -- van Berkel, C -- Bhatnagar, S -- Sapolsky, R M -- AG-06633/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1988 Feb 12;239(4841 Pt 1):766-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3340858" target="_blank"〉PubMed〈/a〉
    Keywords: Aging ; Animals ; Animals, Newborn ; Dexamethasone/metabolism ; *Handling (Psychology) ; Hippocampus/*growth & development/physiology/physiopathology ; Learning ; Memory ; Rats ; Receptors, Glucocorticoid/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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