Publication Date:
1996-08-16
Description:
The Tax transactivator of the human T cell leukemia virus type I (HTLV-I) exhibits oncogenic properties. A screen for proteins interacting with Tax yielded a complementary DNA (cDNA) encoding the human Int-6 protein. In mice, the Int-6 gene can be converted into a putative dominant negative oncogene after retroviral insertion. Here, Int-6 was localized in the cell nucleus to give a speckled staining pattern superposed to that of the promyelocytic leukemia (PML) protein. The binding of Tax to Int-6 caused its redistribution from the nuclear domains to the cytoplasm. Thus, Int-6 is a component of the PML nuclear bodies and Tax disrupts its normal cellular localization by binding to it.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Desbois, C -- Rousset, R -- Bantignies, F -- Jalinot, P -- New York, N.Y. -- Science. 1996 Aug 16;273(5277):951-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre National de la Recherche Scientifique UMR49, Ecole Normale Superieure de Lyon, 69364 Lyon Cedex 07, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8688078" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Line
;
Cell Nucleus/*chemistry
;
Cytoplasm/chemistry
;
Eukaryotic Initiation Factor-3
;
Gene Products, tax/analysis/*metabolism
;
HeLa Cells
;
Humans
;
Mice
;
*Neoplasm Proteins
;
*Nuclear Proteins
;
Proto-Oncogene Proteins/analysis/genetics/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Transcription Factors/*analysis
;
Transfection
;
Tumor Suppressor Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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