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  • 1
    Publication Date: 1978-08-18
    Description: Lead (200 milligrams per kilogram) was administered daily by intubation to Long-Evans rats on days 3 through 30 of life. Thirty to 180 days after cessation of lead administration, the lead-treated rats were consistently more polydipsic after lithium administration (2 millimoles per kilogram per day) than were pair-treated controls. Lithium increased the plasma renin activity equally in both the lead treated and the control groups. These data are evidence that there may be permanent neural changes induced by postnatal exposure to lead that are manifested by pharmacological challenge with lithium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Krigman, M R -- Mueller, R A -- Mushak, P -- Breese, G R -- New York, N.Y. -- Science. 1978 Aug 18;201(4356):637-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/675249" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; *Drinking Behavior/drug effects ; Female ; Lead Poisoning/*physiopathology ; Lithium/pharmacology ; Male ; Rats ; Renin/blood
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1979-08-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Breese, G R -- Krigman, M R -- Mushak, P -- Mueller, R A -- New York, N.Y. -- Science. 1979 Aug 17;205(4407):726.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17781262" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1980-02-01
    Description: Biochemical studies have shown that the ability of erythrosine to inhibit dopamine uptake into brain synaptosomal preparations is dependent on the concentration of tissue present in the assay mixture. Thus, the finding that erythrosine inhibits dopamine uptake (which, if true, would provide a plausible explanation of the Feingold hypothesis of childhood hyperactivity) may simply be an artifact that results from nonspecific interactions with brain membranes. In addition, although erythrosine given parenterally (50 milligrams per kilogram) did not alter locomotor activity of control of 6-hydroxydopamine-treated rats, erythrosine (50 to 300 milligrams per kilogram) attenuated the effect of punishment in a "conflict" paradigm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mailman, R B -- Ferris, R M -- Tang, F L -- Vogel, R A -- Kilts, C D -- Lipton, M A -- Smith, D A -- Mueller, R A -- Breese, G R -- New York, N.Y. -- Science. 1980 Feb 1;207(4430):535-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7352264" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/*drug effects ; Biological Transport/drug effects ; Brain/*drug effects/metabolism ; Dopamine/*metabolism ; Food Coloring Agents/*pharmacology ; Hydroxydopamines/pharmacology ; Male ; Motor Activity/drug effects ; Nerve Tissue Proteins/metabolism ; Rats ; Synaptosomes/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2014-08-13
    Description: This work employs in situ measurement data and constructive simulations to examine the underlying physical mechanisms that drive spacecraft plume interactions with the space environment in low Earth orbit. The study centers on observations ofthe enhanced flux of plasma generated during a maneuver of Space Shuttle Endeavour as part of the Sensor Test for Orion Relative Navigation Risk Mitigation (STORRM) experiment in May 2011. The Canary electrostatic analyzer (ESA) instrument mounted on the port-side truss of the International Space Station (ISS) indicated an elevated ion current during the shuttle maneuver. The apparent source of enhanced ion current is a result of interaction of the spacecraft thruster plume with the rarefied ambient ionosphere, which generates regions of relatively high-density plasma through charge exchange between the neutral plume and ambient ions. To reconstruct this event, unsteady simulation data were generated using a combined direct simulation Monte Carlo/Particle in Cell methodology, which employed detailed charge-exchange cross section data and a magnetic field model. The simulation provides local plasma characteristics at the ESA sensor location, and a sensor model is subsequently used to transform the local properties into a prediction of measured ion current. The predicted and observed total current are presented as a function of time over a 30 second period of pulsed thruster firings. A strong correlation is observed in the temporal characteristics of the simulated and measured total current, and good agreement is also achieved in the total current predicted by the model. These results support conclusions that: (1) the enhanced flux of plasma observed by the ESA instrument is associated with Space Shuttle thruster firings, and (2) the simulation model captures the essential features of the plume interactions based on the observation data.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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